DDT | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
B cell	34 studies	32% ± 11%	Explore
natural killer cell	31 studies	28% ± 10%	Explore
endothelial cell	27 studies	28% ± 11%	Explore
macrophage	26 studies	31% ± 13%	Explore
fibroblast	26 studies	27% ± 10%	Explore
conventional dendritic cell	26 studies	39% ± 16%	Explore
T cell	25 studies	28% ± 7%	Explore
CD4-positive, alpha-beta T cell	25 studies	30% ± 11%	Explore
smooth muscle cell	23 studies	28% ± 8%	Explore
classical monocyte	23 studies	34% ± 14%	Explore
CD8-positive, alpha-beta T cell	22 studies	30% ± 10%	Explore
non-classical monocyte	20 studies	34% ± 16%	Explore
epithelial cell	19 studies	48% ± 22%	Explore
pericyte	19 studies	30% ± 7%	Explore
basal cell	18 studies	39% ± 17%	Explore
regulatory T cell	18 studies	29% ± 7%	Explore
plasmacytoid dendritic cell	17 studies	36% ± 13%	Explore
dendritic cell	16 studies	40% ± 23%	Explore
monocyte	16 studies	35% ± 10%	Explore
memory B cell	16 studies	29% ± 6%	Explore
naive B cell	16 studies	26% ± 7%	Explore
endothelial cell of lymphatic vessel	15 studies	30% ± 10%	Explore
ciliated cell	15 studies	37% ± 20%	Explore
gamma-delta T cell	15 studies	29% ± 14%	Explore
mast cell	14 studies	25% ± 6%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	12 studies	30% ± 8%	Explore
plasma cell	11 studies	37% ± 11%	Explore
CD16-positive, CD56-dim natural killer cell, human	11 studies	24% ± 7%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	11 studies	33% ± 13%	Explore
mature NK T cell	11 studies	26% ± 7%	Explore
myofibroblast cell	11 studies	25% ± 7%	Explore
connective tissue cell	11 studies	27% ± 6%	Explore
vein endothelial cell	10 studies	24% ± 7%	Explore
myeloid cell	10 studies	37% ± 20%	Explore
secretory cell	9 studies	43% ± 19%	Explore
CD16-negative, CD56-bright natural killer cell, human	9 studies	30% ± 9%	Explore
progenitor cell	9 studies	55% ± 18%	Explore
abnormal cell	9 studies	40% ± 16%	Explore
mucosal invariant T cell	9 studies	20% ± 3%	Explore
endothelial cell of vascular tree	9 studies	27% ± 6%	Explore
type I pneumocyte	8 studies	35% ± 14%	Explore
type II pneumocyte	8 studies	47% ± 19%	Explore
CD8-positive, alpha-beta memory T cell	8 studies	27% ± 9%	Explore
leukocyte	8 studies	34% ± 13%	Explore
goblet cell	8 studies	43% ± 17%	Explore
plasmablast	7 studies	48% ± 21%	Explore
club cell	7 studies	33% ± 8%	Explore
effector memory CD8-positive, alpha-beta T cell	7 studies	29% ± 12%	Explore
enterocyte	7 studies	51% ± 19%	Explore
T follicular helper cell	7 studies	25% ± 5%	Explore
CD4-positive, alpha-beta memory T cell	6 studies	31% ± 8%	Explore
epithelial cell of proximal tubule	6 studies	57% ± 8%	Explore
kidney loop of Henle epithelial cell	6 studies	41% ± 12%	Explore
renal alpha-intercalated cell	6 studies	55% ± 13%	Explore
capillary endothelial cell	6 studies	21% ± 4%	Explore
endothelial cell of artery	6 studies	21% ± 4%	Explore
innate lymphoid cell	6 studies	27% ± 3%	Explore
alveolar macrophage	5 studies	21% ± 3%	Explore
ionocyte	5 studies	37% ± 9%	Explore
effector CD8-positive, alpha-beta T cell	5 studies	27% ± 7%	Explore
mononuclear phagocyte	5 studies	39% ± 19%	Explore
kidney distal convoluted tubule epithelial cell	5 studies	43% ± 12%	Explore
mesothelial cell	5 studies	34% ± 15%	Explore
transit amplifying cell	5 studies	52% ± 26%	Explore
erythrocyte	5 studies	36% ± 21%	Explore
effector memory CD4-positive, alpha-beta T cell	5 studies	30% ± 14%	Explore
hepatocyte	5 studies	59% ± 31%	Explore
hematopoietic precursor cell	4 studies	57% ± 22%	Explore
exhausted T cell	4 studies	39% ± 12%	Explore
enteroendocrine cell	4 studies	53% ± 17%	Explore
intestinal crypt stem cell	4 studies	55% ± 17%	Explore
retinal ganglion cell	4 studies	73% ± 22%	Explore
erythroblast	4 studies	43% ± 24%	Explore
pro-B cell	4 studies	27% ± 8%	Explore
immature B cell	4 studies	35% ± 13%	Explore
precursor B cell	4 studies	31% ± 12%	Explore
astrocyte	4 studies	31% ± 16%	Explore
intermediate monocyte	4 studies	45% ± 21%	Explore
luminal hormone-sensing cell of mammary gland	4 studies	36% ± 10%	Explore
neuron	4 studies	40% ± 19%	Explore
T-helper 17 cell	4 studies	29% ± 10%	Explore
deuterosomal cell	3 studies	21% ± 7%	Explore
duct epithelial cell	3 studies	31% ± 4%	Explore
pancreatic A cell	3 studies	41% ± 18%	Explore
type B pancreatic cell	3 studies	41% ± 21%	Explore
podocyte	3 studies	32% ± 5%	Explore
neural crest cell	3 studies	33% ± 4%	Explore
IgA plasma cell	3 studies	18% ± 3%	Explore
IgG plasma cell	3 studies	17% ± 1%	Explore
renal principal cell	3 studies	54% ± 5%	Explore
extravillous trophoblast	3 studies	36% ± 8%	Explore
placental villous trophoblast	3 studies	52% ± 8%	Explore
common myeloid progenitor	3 studies	43% ± 21%	Explore
lymphocyte	3 studies	44% ± 13%	Explore
brush cell	3 studies	29% ± 17%	Explore
neuroendocrine cell	3 studies	34% ± 12%	Explore
retinal cone cell	3 studies	59% ± 14%	Explore
retinal rod cell	3 studies	31% ± 3%	Explore
mucus secreting cell	3 studies	41% ± 17%	Explore
serous secreting cell	3 studies	53% ± 11%	Explore
intraepithelial lymphocyte	3 studies	30% ± 10%	Explore
germinal center B cell	3 studies	35% ± 4%	Explore
effector CD4-positive, alpha-beta T cell	3 studies	24% ± 4%	Explore
CD4-positive helper T cell	3 studies	24% ± 6%	Explore
granulocyte	3 studies	22% ± 7%	Explore
luminal cell of prostate epithelium	3 studies	46% ± 8%	Explore
group 3 innate lymphoid cell	3 studies	36% ± 20%	Explore
keratinocyte	3 studies	28% ± 1%	Explore
progenitor cell of mammary luminal epithelium	3 studies	36% ± 9%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
lung	16 studies	35% ± 15%	Explore
peripheral blood	15 studies	32% ± 12%	Explore
intestine	11 studies	35% ± 17%	Explore
kidney	8 studies	37% ± 11%	Explore
liver	8 studies	36% ± 22%	Explore
eye	5 studies	30% ± 9%	Explore
lymph node	5 studies	38% ± 12%	Explore
uterus	4 studies	43% ± 17%	Explore
prostate	4 studies	26% ± 9%	Explore
breast	4 studies	29% ± 7%	Explore
brain	4 studies	21% ± 3%	Explore
pancreas	3 studies	45% ± 17%	Explore
placenta	3 studies	35% ± 10%	Explore
bone marrow	3 studies	23% ± 5%	Explore
adrenal gland	3 studies	26% ± 11%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Number of samples
adrenal gland	100%	1032.51	258 / 258	0%	0 / 230
bladder	100%	750.67	21 / 21	0%	0 / 504
breast	100%	901.75	459 / 459	0%	0 / 1118
esophagus	100%	845.03	1445 / 1445	0%	0 / 183
intestine	100%	964.69	966 / 966	0%	0 / 527
kidney	100%	1618.82	89 / 89	0%	0 / 901
liver	100%	3759.46	226 / 226	0%	0 / 406
ovary	100%	691.76	180 / 180	0%	0 / 430
pancreas	100%	1258.59	328 / 328	0%	0 / 178
prostate	100%	1000.36	245 / 245	0%	0 / 502
spleen	100%	582.29	241 / 241	0%	0 / 0
stomach	100%	1130.20	359 / 359	0%	0 / 286
uterus	100%	564.24	170 / 170	0%	0 / 459
skin	100%	794.28	1808 / 1809	0%	0 / 472
adipose	100%	940.15	1203 / 1204	0%	0 / 0
thymus	100%	766.59	652 / 653	0%	0 / 605
blood vessel	100%	718.51	1331 / 1335	0%	0 / 0
brain	100%	607.45	2629 / 2642	0%	0 / 705
muscle	100%	624.65	799 / 803	0%	0 / 0
lung	99%	644.28	575 / 578	0%	0 / 1155
peripheral blood	97%	731.85	901 / 929	0%	0 / 0
heart	97%	874.36	835 / 861	0%	0 / 0
abdomen	0%	0	0 / 0	0%	0 / 0
bone marrow	0%	0	0 / 0	0%	0 / 0
diaphragm	0%	0	0 / 0	0%	0 / 0
eye	0%	0	0 / 0	0%	0 / 80
gingiva	0%	0	0 / 0	0%	0 / 0
lymph node	0%	0	0 / 0	0%	0 / 29
nasal cavity	0%	0	0 / 0	0%	0 / 0
nasopharynx	0%	0	0 / 0	0%	0 / 0
nose	0%	0	0 / 0	0%	0 / 0
placenta	0%	0	0 / 0	0%	0 / 0
spinal column	0%	0	0 / 0	0%	0 / 0
tonsil	0%	0	0 / 0	0%	0 / 45
ureter	0%	0	0 / 0	0%	0 / 1

III. Associated gene sets

GO_0050729	Biological process	positive regulation of inflammatory response
GO_0042438	Biological process	melanin biosynthetic process
GO_0070374	Biological process	positive regulation of ERK1 and ERK2 cascade
GO_0032760	Biological process	positive regulation of tumor necrosis factor production
GO_0010760	Biological process	negative regulation of macrophage chemotaxis
GO_0005615	Cellular component	extracellular space
GO_0070062	Cellular component	extracellular exosome
GO_0005737	Cellular component	cytoplasm
GO_0050178	Molecular function	phenylpyruvate tautomerase activity
GO_0004167	Molecular function	dopachrome isomerase activity
GO_0033981	Molecular function	D-dopachrome decarboxylase activity
GO_0005126	Molecular function	cytokine receptor binding

IV. Literature review

[source]

Gene name	DDT
Protein name	D-dopachrome tautomerase (D-dopachrome tautomerase, isoform CRA_b) (cDNA FLJ76419, highly similar to Homo sapiens D-dopachrome tautomerase (DDT), mRNA) D-dopachrome decarboxylase (EC 4.1.1.84) (D-dopachrome tautomerase) (Phenylpyruvate tautomerase II) D-dopachrome decarboxylase (D-dopachrome tautomerase) D-dopachrome decarboxylase (EC 4.1.1.84)
Synonyms	hCG_41098 DDT1
Description	FUNCTION: Tautomerization of D-dopachrome with decarboxylation to give 5,6-dihydroxyindole (DHI). . FUNCTION: Tautomerization of D-dopachrome with decarboxylation to give 5,6-dihydroxyindole (DHI). .
Accessions	ENST00000350608.7 [P30046-1] ENST00000703965.1 Q53Y51 ENST00000403754.7 ENST00000629401.2 [P30046-2] H7C342 J3KQ18 ENST00000629936.1 P30046 ENST00000626871.2 [P30046-1] ENST00000428792.1 ENST00000430101.2 [P30046-2] B5MC82 ENST00000626046.2 ENST00000398344.9 [P30046-1] ENST00000626838.1 ENST00000615721.3 [P30046-1]

DDT report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review