DENND2B report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0070374Biological processpositive regulation of ERK1 and ERK2 cascade
GO_0005938Cellular componentcell cortex
GO_0005886Cellular componentplasma membrane
GO_0055037Cellular componentrecycling endosome
GO_0005085Molecular functionguanyl-nucleotide exchange factor activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameDENND2B
Protein nameDENN domain-containing protein 2B (HeLa tumor suppression 1) (Suppression of tumorigenicity 5 protein)
DENN domain containing 2B
DENN domain containing 2B (cDNA FLJ55510, highly similar to Suppression of tumorigenicity 5)
SynonymsHTS1
ST5
DescriptionFUNCTION: [Isoform 1]: May be involved in cytoskeletal organization and tumorogenicity. Seems to be involved in a signaling transduction pathway leading to activation of MAPK1/ERK2. Plays a role in EGFR trafficking from recycling endosomes back to the cell membrane . .; FUNCTION: [Isoform 2]: Guanine nucleotide exchange factor (GEF) which may activate RAB9A and RAB9B. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form. .; FUNCTION: [Isoform 3]: May block ERK2 activation stimulated by ABL1 (Probable). May alter cell morphology and cell growth (Probable). .

AccessionsE9PLR2
E9PI72
ENST00000530438.5 [P78524-2]
E9PNX7
ENST00000531060.1
ENST00000626808.2
ENST00000533580.5
E9PLB6
ENST00000526757.5 [P78524-2]
ENST00000526126.5
P78524
E9PI58
ENST00000533681.5
ENST00000524757.5
ENST00000525169.5
ENST00000526241.5
E9PLH5
ENST00000534278.5
ENST00000527930.5
E9PLD7
E9PPL2
E9PKE0
ENST00000526828.5
E9PJY5
ENST00000527473.5
ENST00000527392.5
ENST00000526062.5
H0YE59
H0YD60
E9PME1
E9PPS6
ENST00000531093.5
ENST00000527510.5
E9PII1
E9PMJ9
ENST00000533471.5
ENST00000530580.5
ENST00000530938.5
ENST00000534127.5 [P78524-1]
E9PKM1
E9PN93
E9PI67
ENST00000530991.5 [P78524-3]
ENST00000526057.5
ENST00000528196.5
E9PKV3
E9PRS6
E9PJP0
H0YDL0
ENST00000528523.5
ENST00000530593.5
B4DDL8
ENST00000530338.5
ENST00000531578.1
E9PLH6
E9PK36
E9PQA9
E9PM84
ENST00000534248.5
ENST00000533020.5
E9PKN3
E9PQM5
ENST00000533016.1
ENST00000532734.5
ENST00000530959.5
ENST00000527516.5
E9PMP1
E9PNM8
ENST00000313726.11 [P78524-1]
ENST00000533225.5
ENST00000526155.5
E9PJC3
E9PQU6
ENST00000527347.5
ENST00000526099.5
ENST00000528527.5
ENST00000534665.5
E9PM32