FGF23 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of FGF23 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of FGF23 at tissue level.

III. Associated gene sets

GO_0046888Biological processnegative regulation of hormone secretion
GO_0055074Biological processcalcium ion homeostasis
GO_0055062Biological processphosphate ion homeostasis
GO_0030643Biological processintracellular phosphate ion homeostasis
GO_0032026Biological processresponse to magnesium ion
GO_0071305Biological processcellular response to vitamin D
GO_0009887Biological processanimal organ morphogenesis
GO_0010628Biological processpositive regulation of gene expression
GO_0042369Biological processvitamin D catabolic process
GO_0001934Biological processpositive regulation of protein phosphorylation
GO_0043410Biological processpositive regulation of MAPK cascade
GO_0010980Biological processpositive regulation of vitamin D 24-hydroxylase activity
GO_0071374Biological processcellular response to parathyroid hormone stimulus
GO_1904383Biological processresponse to sodium phosphate
GO_0070371Biological processERK1 and ERK2 cascade
GO_0044320Biological processcellular response to leptin stimulus
GO_0045893Biological processpositive regulation of DNA-templated transcription
GO_0030154Biological processcell differentiation
GO_0030334Biological processregulation of cell migration
GO_0030502Biological processnegative regulation of bone mineralization
GO_0045668Biological processnegative regulation of osteoblast differentiation
GO_0008284Biological processpositive regulation of cell population proliferation
GO_0090080Biological processpositive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway
GO_0070374Biological processpositive regulation of ERK1 and ERK2 cascade
GO_0071354Biological processcellular response to interleukin-6
GO_0008543Biological processfibroblast growth factor receptor signaling pathway
GO_0010966Biological processregulation of phosphate transport
GO_0005615Cellular componentextracellular space
GO_0005576Cellular componentextracellular region
GO_0005796Cellular componentGolgi lumen
GO_0005788Cellular componentendoplasmic reticulum lumen
GO_0005737Cellular componentcytoplasm
GO_0008083Molecular functiongrowth factor activity
GO_0005105Molecular functiontype 1 fibroblast growth factor receptor binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameFGF23
Protein nameFibroblast growth factor 23
Fibroblast growth factor 23 (FGF-23) (Phosphatonin) (Tumor-derived hypophosphatemia-inducing factor) [Cleaved into: Fibroblast growth factor 23 N-terminal peptide; Fibroblast growth factor 23 C-terminal peptide]
SynonymsUNQ3027/PRO9828
HYPF
DescriptionFUNCTION: Regulator of phosphate homeostasis . Inhibits renal tubular phosphate transport by reducing SLC34A1 levels . Up-regulates EGR1 expression in the presence of KL (By similarity). Acts directly on the parathyroid to decrease PTH secretion (By similarity). Regulator of vitamin-D metabolism . Negatively regulates osteoblast differentiation and matrix mineralization . .

AccessionsQ9GZV9
ENST00000237837.2
Q7Z4T2