TNFAIP8L3 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of TNFAIP8L3 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of TNFAIP8L3 at tissue level.

III. Associated gene sets

GO_0006644Biological processphospholipid metabolic process
GO_0120009Biological processintermembrane lipid transfer
GO_0042981Biological processregulation of apoptotic process
GO_1902633Biological process1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate metabolic process
GO_0070374Biological processpositive regulation of ERK1 and ERK2 cascade
GO_0015914Biological processphospholipid transport
GO_0005654Cellular componentnucleoplasm
GO_0005829Cellular componentcytosol
GO_0005886Cellular componentplasma membrane
GO_0005737Cellular componentcytoplasm
GO_0008526Molecular functionphosphatidylinositol transfer activity
GO_0005515Molecular functionprotein binding
GO_0035091Molecular functionphosphatidylinositol binding

IV. Literature review

[source]
Gene nameTNFAIP8L3
Protein nameTNF alpha induced protein 8 like 3
Tumor necrosis factor alpha-induced protein 8-like protein 3 (TNF alpha-induced protein 8-like protein 3) (TNFAIP8-like protein 3)
SynonymsTIPE3
DescriptionFUNCTION: Acts as a lipid transfer protein. Preferentially captures and shuttles two lipid second messengers, i.e., phosphatidylinositol 4,5- bisphosphate and phosphatidylinositol 3,4,5-trisphosphate and increases their levels in the plasma membrane. Additionally, may also function as a lipid-presenting protein to enhance the activity of the PI3K-AKT and MEK-ERK pathways. May act as a regulator of tumorigenesis through its activation of phospholipid signaling. .

AccessionsA0A1B0GTK8
Q5GJ75
ENST00000327536.5
A0A494C051
ENST00000649177.1
ENST00000637513.2