Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| retinal cone cell | 5 studies | 27% ± 8% | |
| endothelial cell | 3 studies | 19% ± 4% | |
| epithelial cell | 3 studies | 30% ± 8% | |
| glutamatergic neuron | 3 studies | 19% ± 2% | |
| transit amplifying cell | 3 studies | 37% ± 23% |
Insufficient scRNA-seq data for expression of ECT2 at tissue level.
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| esophagus | 100% | 734.01 | 1440 / 1445 | 99% | 85.79 | 182 / 183 |
| intestine | 100% | 688.23 | 964 / 966 | 98% | 58.51 | 515 / 527 |
| lung | 99% | 804.73 | 575 / 578 | 97% | 53.66 | 1121 / 1155 |
| breast | 100% | 620.26 | 459 / 459 | 97% | 41.25 | 1079 / 1118 |
| stomach | 99% | 637.71 | 354 / 359 | 98% | 60.00 | 279 / 286 |
| uterus | 99% | 370.58 | 169 / 170 | 96% | 61.27 | 440 / 459 |
| bladder | 100% | 387.76 | 21 / 21 | 89% | 38.25 | 450 / 504 |
| skin | 100% | 1652.53 | 1803 / 1809 | 75% | 17.16 | 354 / 472 |
| ovary | 74% | 169.10 | 133 / 180 | 100% | 43.51 | 428 / 430 |
| pancreas | 76% | 188.03 | 249 / 328 | 89% | 22.70 | 158 / 178 |
| prostate | 98% | 359.50 | 240 / 245 | 52% | 8.25 | 263 / 502 |
| kidney | 99% | 509.30 | 88 / 89 | 47% | 6.98 | 427 / 901 |
| brain | 96% | 362.54 | 2547 / 2642 | 46% | 9.74 | 325 / 705 |
| thymus | 99% | 374.09 | 649 / 653 | 19% | 2.90 | 113 / 605 |
| adrenal gland | 97% | 510.47 | 249 / 258 | 16% | 2.98 | 36 / 230 |
| spleen | 100% | 585.44 | 241 / 241 | 0% | 0 | 0 / 0 |
| tonsil | 0% | 0 | 0 / 0 | 100% | 74.89 | 45 / 45 |
| adipose | 100% | 567.49 | 1203 / 1204 | 0% | 0 | 0 / 0 |
| blood vessel | 92% | 283.00 | 1229 / 1335 | 0% | 0 | 0 / 0 |
| heart | 90% | 255.63 | 773 / 861 | 0% | 0 | 0 / 0 |
| liver | 52% | 171.37 | 117 / 226 | 38% | 7.72 | 153 / 406 |
| lymph node | 0% | 0 | 0 / 0 | 66% | 11.48 | 19 / 29 |
| peripheral blood | 62% | 768.93 | 577 / 929 | 0% | 0 | 0 / 0 |
| muscle | 62% | 122.10 | 494 / 803 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 80 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
| GO_0051260 | Biological process | protein homooligomerization |
| GO_0045859 | Biological process | regulation of protein kinase activity |
| GO_2000431 | Biological process | regulation of cytokinesis, actomyosin contractile ring assembly |
| GO_0043547 | Biological process | positive regulation of GTPase activity |
| GO_0090630 | Biological process | activation of GTPase activity |
| GO_0051056 | Biological process | regulation of small GTPase mediated signal transduction |
| GO_0042307 | Biological process | positive regulation of protein import into nucleus |
| GO_0051988 | Biological process | regulation of attachment of spindle microtubules to kinetochore |
| GO_0000281 | Biological process | mitotic cytokinesis |
| GO_1903438 | Biological process | positive regulation of mitotic cytokinetic process |
| GO_0071277 | Biological process | cellular response to calcium ion |
| GO_0032147 | Biological process | activation of protein kinase activity |
| GO_0035556 | Biological process | intracellular signal transduction |
| GO_0043123 | Biological process | positive regulation of canonical NF-kappaB signal transduction |
| GO_0030154 | Biological process | cell differentiation |
| GO_0070830 | Biological process | bicellular tight junction assembly |
| GO_0015031 | Biological process | protein transport |
| GO_0000902 | Biological process | cell morphogenesis |
| GO_0045666 | Biological process | positive regulation of neuron differentiation |
| GO_0071479 | Biological process | cellular response to ionizing radiation |
| GO_0043065 | Biological process | positive regulation of apoptotic process |
| GO_0032467 | Biological process | positive regulation of cytokinesis |
| GO_0007399 | Biological process | nervous system development |
| GO_0070301 | Biological process | cellular response to hydrogen peroxide |
| GO_0030496 | Cellular component | midbody |
| GO_0072686 | Cellular component | mitotic spindle |
| GO_0005813 | Cellular component | centrosome |
| GO_0005654 | Cellular component | nucleoplasm |
| GO_0005911 | Cellular component | cell-cell junction |
| GO_0016604 | Cellular component | nuclear body |
| GO_0005829 | Cellular component | cytosol |
| GO_0005938 | Cellular component | cell cortex |
| GO_0097149 | Cellular component | centralspindlin complex |
| GO_0005737 | Cellular component | cytoplasm |
| GO_0005923 | Cellular component | bicellular tight junction |
| GO_0032154 | Cellular component | cleavage furrow |
| GO_0005634 | Cellular component | nucleus |
| GO_0042803 | Molecular function | protein homodimerization activity |
| GO_0005085 | Molecular function | guanyl-nucleotide exchange factor activity |
| GO_0031267 | Molecular function | small GTPase binding |
| GO_0005096 | Molecular function | GTPase activator activity |
| GO_0005515 | Molecular function | protein binding |
| Gene name | ECT2 |
| Protein name | Epithelial cell transforming 2 Protein ECT2 (Epithelial cell-transforming sequence 2 oncogene) |
| Synonyms | |
| Description | FUNCTION: Guanine nucleotide exchange factor (GEF) that catalyzes the exchange of GDP for GTP. Promotes guanine nucleotide exchange on the Rho family members of small GTPases, like RHOA, RHOC, RAC1 and CDC42. Required for signal transduction pathways involved in the regulation of cytokinesis. Component of the centralspindlin complex that serves as a microtubule-dependent and Rho-mediated signaling required for the myosin contractile ring formation during the cell cycle cytokinesis. Regulates the translocation of RHOA from the central spindle to the equatorial region. Plays a role in the control of mitotic spindle assembly; regulates the activation of CDC42 in metaphase for the process of spindle fibers attachment to kinetochores before chromosome congression. Involved in the regulation of epithelial cell polarity; participates in the formation of epithelial tight junctions in a polarity complex PARD3-PARD6-protein kinase PRKCQ-dependent manner. Plays a role in the regulation of neurite outgrowth. Inhibits phenobarbital (PB)-induced NR1I3 nuclear translocation. Stimulates the activity of RAC1 through its association with the oncogenic PARD6A-PRKCI complex in cancer cells, thereby acting to coordinately drive tumor cell proliferation and invasion. Also stimulates genotoxic stress-induced RHOB activity in breast cancer cells leading to their cell death. . |
| Accessions | H7C103 ENST00000438041.5 H7C3G1 ENST00000232458.9 [Q9H8V3-4] ENST00000444250.1 C9JDB4 ENST00000366254.2 C9J1C4 C9JB41 C9JDV9 ENST00000437296.1 ENST00000540509.5 [Q9H8V3-4] ENST00000366090.6 C9JTI2 ENST00000441497.6 [Q9H8V3-4] ENST00000392692.8 [Q9H8V3-1] ENST00000417960.5 [Q9H8V3-2] Q9H8V3 ENST00000415665.5 ENST00000426894.5 ENST00000428567.5 C9J0L6 |
