Name | Number of supported studies | Average coverage | |
---|---|---|---|
endothelial cell | 6 studies | 21% ± 6% | |
epithelial cell | 5 studies | 26% ± 10% | |
natural killer cell | 4 studies | 19% ± 1% | |
CD16-negative, CD56-bright natural killer cell, human | 3 studies | 17% ± 1% | |
CD4-positive, alpha-beta T cell | 3 studies | 19% ± 0% | |
non-classical monocyte | 3 studies | 23% ± 5% | |
fibroblast | 3 studies | 21% ± 5% | |
abnormal cell | 3 studies | 20% ± 3% | |
GABAergic neuron | 3 studies | 29% ± 6% | |
astrocyte | 3 studies | 16% ± 1% | |
glutamatergic neuron | 3 studies | 39% ± 10% | |
dendritic cell | 3 studies | 32% ± 8% | |
basal cell | 3 studies | 24% ± 6% | |
plasmacytoid dendritic cell | 3 studies | 21% ± 3% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
bladder | 100% | 3576.57 | 21 / 21 | 100% | 51.21 | 504 / 504 |
breast | 100% | 3646.76 | 459 / 459 | 100% | 56.17 | 1118 / 1118 |
esophagus | 100% | 3270.79 | 1445 / 1445 | 100% | 43.74 | 183 / 183 |
liver | 100% | 1668.06 | 226 / 226 | 100% | 34.52 | 406 / 406 |
lung | 100% | 2755.08 | 578 / 578 | 100% | 50.25 | 1155 / 1155 |
ovary | 100% | 3489.51 | 180 / 180 | 100% | 49.00 | 430 / 430 |
pancreas | 100% | 1978.98 | 328 / 328 | 100% | 40.58 | 178 / 178 |
prostate | 100% | 3434.29 | 245 / 245 | 100% | 52.06 | 502 / 502 |
stomach | 100% | 2507.69 | 359 / 359 | 100% | 43.45 | 286 / 286 |
uterus | 100% | 3900.74 | 170 / 170 | 100% | 59.77 | 459 / 459 |
intestine | 100% | 3396.15 | 966 / 966 | 100% | 44.34 | 526 / 527 |
skin | 100% | 3737.94 | 1809 / 1809 | 100% | 58.15 | 471 / 472 |
kidney | 100% | 2563.58 | 89 / 89 | 100% | 41.79 | 899 / 901 |
brain | 100% | 2366.52 | 2634 / 2642 | 100% | 56.37 | 705 / 705 |
thymus | 100% | 3231.12 | 653 / 653 | 100% | 42.20 | 603 / 605 |
adrenal gland | 100% | 3387.62 | 258 / 258 | 100% | 42.72 | 229 / 230 |
adipose | 100% | 3494.59 | 1204 / 1204 | 0% | 0 | 0 / 0 |
blood vessel | 100% | 3412.77 | 1335 / 1335 | 0% | 0 | 0 / 0 |
lymph node | 0% | 0 | 0 / 0 | 100% | 74.03 | 29 / 29 |
spleen | 100% | 3666.62 | 241 / 241 | 0% | 0 | 0 / 0 |
tonsil | 0% | 0 | 0 / 0 | 100% | 53.87 | 45 / 45 |
ureter | 0% | 0 | 0 / 0 | 100% | 26.52 | 1 / 1 |
muscle | 100% | 2393.00 | 802 / 803 | 0% | 0 | 0 / 0 |
heart | 99% | 1763.18 | 854 / 861 | 0% | 0 | 0 / 0 |
eye | 0% | 0 | 0 / 0 | 98% | 29.52 | 78 / 80 |
peripheral blood | 89% | 1833.62 | 828 / 929 | 0% | 0 | 0 / 0 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
GO_0014003 | Biological process | oligodendrocyte development |
GO_0002183 | Biological process | cytoplasmic translational initiation |
GO_0009408 | Biological process | response to heat |
GO_0006413 | Biological process | translational initiation |
GO_0043434 | Biological process | response to peptide hormone |
GO_0009749 | Biological process | response to glucose |
GO_0050852 | Biological process | T cell receptor signaling pathway |
GO_0005829 | Cellular component | cytosol |
GO_0005851 | Cellular component | eukaryotic translation initiation factor 2B complex |
GO_0005886 | Cellular component | plasma membrane |
GO_0016020 | Cellular component | membrane |
GO_0005737 | Cellular component | cytoplasm |
GO_0003743 | Molecular function | translation initiation factor activity |
GO_0005085 | Molecular function | guanyl-nucleotide exchange factor activity |
GO_0005515 | Molecular function | protein binding |
GO_0042802 | Molecular function | identical protein binding |
Gene name | EIF2B1 |
Protein name | Translation initiation factor eIF2B subunit alpha (eIF2B GDP-GTP exchange factor subunit alpha) |
Synonyms | EIF2BA |
Description | FUNCTION: Acts as a component of the translation initiation factor 2B (eIF2B) complex, which catalyzes the exchange of GDP for GTP on eukaryotic initiation factor 2 (eIF2) gamma subunit . Its guanine nucleotide exchange factor activity is repressed when bound to eIF2 complex phosphorylated on the alpha subunit, thereby limiting the amount of methionyl-initiator methionine tRNA available to the ribosome and consequently global translation is repressed . . |
Accessions | Q14232 ENST00000424014.7 [Q14232-1] ENST00000537073.1 [Q14232-2] ENST00000539951.5 F5H0D0 H0YGG4 ENST00000534960.5 |