I. Expression across cell types
Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| endothelial cell | 6 studies | 22% ± 10% | |
| myeloid cell | 3 studies | 25% ± 2% | |
| pericyte | 3 studies | 18% ± 2% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| endothelial cell | 6 studies | 22% ± 10% | |
| myeloid cell | 3 studies | 25% ± 2% | |
| pericyte | 3 studies | 18% ± 2% |
Insufficient scRNA-seq data for expression of PLEKHG2 at tissue level.
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| esophagus | 98% | 3652.84 | 1414 / 1445 | 100% | 21.77 | 183 / 183 |
| ovary | 100% | 4080.00 | 180 / 180 | 97% | 29.14 | 416 / 430 |
| lung | 100% | 8741.86 | 578 / 578 | 96% | 19.78 | 1112 / 1155 |
| thymus | 100% | 4038.18 | 652 / 653 | 96% | 17.68 | 582 / 605 |
| uterus | 100% | 6256.42 | 170 / 170 | 95% | 19.74 | 435 / 459 |
| breast | 100% | 4379.17 | 459 / 459 | 93% | 11.37 | 1038 / 1118 |
| bladder | 100% | 3756.95 | 21 / 21 | 88% | 11.22 | 442 / 504 |
| skin | 92% | 2531.25 | 1658 / 1809 | 93% | 13.87 | 439 / 472 |
| stomach | 94% | 2786.78 | 339 / 359 | 89% | 13.07 | 255 / 286 |
| intestine | 99% | 4325.70 | 960 / 966 | 83% | 9.81 | 440 / 527 |
| kidney | 100% | 2839.87 | 89 / 89 | 78% | 14.22 | 705 / 901 |
| prostate | 100% | 4425.68 | 244 / 245 | 72% | 5.66 | 359 / 502 |
| adrenal gland | 97% | 1873.66 | 251 / 258 | 48% | 4.45 | 110 / 230 |
| pancreas | 48% | 582.76 | 156 / 328 | 95% | 17.17 | 169 / 178 |
| brain | 34% | 382.57 | 895 / 2642 | 95% | 16.65 | 670 / 705 |
| adipose | 100% | 5791.77 | 1204 / 1204 | 0% | 0 | 0 / 0 |
| blood vessel | 100% | 6261.25 | 1335 / 1335 | 0% | 0 | 0 / 0 |
| lymph node | 0% | 0 | 0 / 0 | 100% | 23.93 | 29 / 29 |
| spleen | 100% | 6822.96 | 241 / 241 | 0% | 0 | 0 / 0 |
| ureter | 0% | 0 | 0 / 0 | 100% | 4.63 | 1 / 1 |
| heart | 99% | 2943.32 | 853 / 861 | 0% | 0 | 0 / 0 |
| tonsil | 0% | 0 | 0 / 0 | 93% | 12.40 | 42 / 45 |
| liver | 37% | 483.52 | 83 / 226 | 48% | 5.30 | 195 / 406 |
| peripheral blood | 84% | 2475.81 | 784 / 929 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 51% | 3.91 | 41 / 80 |
| muscle | 39% | 503.15 | 314 / 803 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| GO_0030833 | Biological process | regulation of actin filament polymerization |
| GO_0005829 | Cellular component | cytosol |
| GO_0005085 | Molecular function | guanyl-nucleotide exchange factor activity |
| GO_0005515 | Molecular function | protein binding |
| GO_0031267 | Molecular function | small GTPase binding |
| Gene name | PLEKHG2 |
| Protein name | Pleckstrin homology and RhoGEF domain containing G2 Pleckstrin homology domain-containing family G member 2 (PH domain-containing family G member 2) |
| Synonyms | |
| Description | FUNCTION: May be a transforming oncogene with exchange activity for CDC42 (By similarity). May be a guanine-nucleotide exchange factor (GEF) for RAC1 and CDC42. Activated by the binding to subunits beta and gamma of the heterotrimeric guanine nucleotide-binding protein (G protein) . Involved in the regulation of actin polymerization . . |
| Accessions | C9J7S4 Q9H7P9 ENST00000596339.1 ENST00000594124.1 ENST00000451354.6 ENST00000205135.8 H7BXC7 ENST00000596443.1 M0R348 ENST00000594161.1 M0QX05 C9JVL3 M0R0V0 ENST00000409797.6 [Q9H7P9-2] ENST00000438123.5 ENST00000425673.6 [Q9H7P9-1] M0R3J0 M0R3G5 ENST00000598238.1 ENST00000600210.1 M0R391 M0QZT7 ENST00000458508.6 ENST00000595920.1 E7ESZ3 |
