Name | Number of supported studies | Average coverage | |
---|---|---|---|
endothelial cell | 31 studies | 42% ± 17% | |
macrophage | 21 studies | 39% ± 21% | |
microglial cell | 14 studies | 57% ± 19% | |
B cell | 10 studies | 34% ± 14% | |
dendritic cell | 10 studies | 44% ± 15% | |
astrocyte | 10 studies | 27% ± 12% | |
oligodendrocyte precursor cell | 10 studies | 29% ± 13% | |
myeloid cell | 10 studies | 43% ± 17% | |
monocyte | 9 studies | 43% ± 18% | |
non-classical monocyte | 9 studies | 30% ± 11% | |
endothelial cell of artery | 9 studies | 31% ± 16% | |
T cell | 8 studies | 31% ± 8% | |
natural killer cell | 8 studies | 30% ± 11% | |
pericyte | 8 studies | 28% ± 13% | |
GABAergic neuron | 7 studies | 40% ± 21% | |
adipocyte | 7 studies | 23% ± 6% | |
capillary endothelial cell | 7 studies | 33% ± 12% | |
classical monocyte | 6 studies | 26% ± 6% | |
leukocyte | 6 studies | 44% ± 20% | |
CD8-positive, alpha-beta T cell | 6 studies | 29% ± 9% | |
conventional dendritic cell | 6 studies | 28% ± 10% | |
glutamatergic neuron | 6 studies | 43% ± 25% | |
interneuron | 6 studies | 37% ± 21% | |
epithelial cell | 6 studies | 34% ± 15% | |
retina horizontal cell | 6 studies | 47% ± 21% | |
fibroblast | 6 studies | 26% ± 13% | |
CD16-positive, CD56-dim natural killer cell, human | 5 studies | 29% ± 11% | |
CD4-positive, alpha-beta T cell | 5 studies | 28% ± 9% | |
plasma cell | 5 studies | 42% ± 11% | |
ciliated cell | 5 studies | 26% ± 9% | |
endothelial cell of lymphatic vessel | 5 studies | 28% ± 3% | |
mononuclear phagocyte | 4 studies | 29% ± 16% | |
mature NK T cell | 4 studies | 26% ± 12% | |
granule cell | 4 studies | 29% ± 7% | |
Mueller cell | 4 studies | 27% ± 11% | |
endothelial cell of vascular tree | 4 studies | 46% ± 25% | |
memory B cell | 4 studies | 24% ± 5% | |
alveolar macrophage | 4 studies | 55% ± 26% | |
smooth muscle cell | 4 studies | 20% ± 3% | |
oligodendrocyte | 4 studies | 23% ± 5% | |
naive B cell | 3 studies | 20% ± 2% | |
GABAergic interneuron | 3 studies | 25% ± 8% | |
neuron | 3 studies | 38% ± 9% | |
effector memory CD8-positive, alpha-beta T cell | 3 studies | 30% ± 6% | |
vein endothelial cell | 3 studies | 46% ± 19% | |
hepatocyte | 3 studies | 38% ± 25% | |
ependymal cell | 3 studies | 50% ± 8% | |
type I pneumocyte | 3 studies | 22% ± 4% | |
CD8-positive, alpha-beta memory T cell | 3 studies | 21% ± 3% | |
lymphocyte | 3 studies | 54% ± 14% | |
basal cell | 3 studies | 38% ± 23% | |
goblet cell | 3 studies | 33% ± 19% | |
mast cell | 3 studies | 27% ± 15% | |
mural cell | 3 studies | 47% ± 13% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
brain | 100% | 7464.52 | 2638 / 2642 | 100% | 74.25 | 704 / 705 |
intestine | 100% | 7878.90 | 966 / 966 | 100% | 41.78 | 525 / 527 |
prostate | 100% | 6133.58 | 245 / 245 | 100% | 38.09 | 500 / 502 |
skin | 100% | 4696.17 | 1807 / 1809 | 100% | 69.79 | 470 / 472 |
kidney | 100% | 5684.74 | 89 / 89 | 99% | 58.65 | 896 / 901 |
lung | 100% | 11810.09 | 578 / 578 | 99% | 50.28 | 1148 / 1155 |
esophagus | 100% | 6220.88 | 1444 / 1445 | 99% | 62.59 | 182 / 183 |
thymus | 100% | 6453.95 | 652 / 653 | 100% | 46.06 | 602 / 605 |
stomach | 100% | 5177.17 | 359 / 359 | 99% | 48.09 | 284 / 286 |
breast | 100% | 7329.59 | 459 / 459 | 99% | 45.27 | 1110 / 1118 |
uterus | 100% | 6325.06 | 170 / 170 | 98% | 37.63 | 448 / 459 |
ovary | 100% | 3808.26 | 180 / 180 | 97% | 36.49 | 419 / 430 |
pancreas | 99% | 5483.55 | 325 / 328 | 98% | 43.61 | 174 / 178 |
bladder | 100% | 6418.90 | 21 / 21 | 97% | 34.99 | 488 / 504 |
adrenal gland | 100% | 5969.39 | 258 / 258 | 94% | 31.57 | 216 / 230 |
liver | 96% | 3400.68 | 218 / 226 | 93% | 24.70 | 376 / 406 |
adipose | 100% | 7647.58 | 1204 / 1204 | 0% | 0 | 0 / 0 |
eye | 0% | 0 | 0 / 0 | 100% | 145.18 | 80 / 80 |
lymph node | 0% | 0 | 0 / 0 | 100% | 128.45 | 29 / 29 |
muscle | 100% | 21152.40 | 803 / 803 | 0% | 0 | 0 / 0 |
spleen | 100% | 10348.26 | 241 / 241 | 0% | 0 | 0 / 0 |
tonsil | 0% | 0 | 0 / 0 | 100% | 51.61 | 45 / 45 |
ureter | 0% | 0 | 0 / 0 | 100% | 26.18 | 1 / 1 |
blood vessel | 100% | 6812.93 | 1334 / 1335 | 0% | 0 | 0 / 0 |
heart | 100% | 6468.95 | 860 / 861 | 0% | 0 | 0 / 0 |
peripheral blood | 98% | 10346.01 | 914 / 929 | 0% | 0 | 0 / 0 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
GO_0007265 | Biological process | Ras protein signal transduction |
GO_0007169 | Biological process | cell surface receptor protein tyrosine kinase signaling pathway |
GO_0010976 | Biological process | positive regulation of neuron projection development |
GO_0043547 | Biological process | positive regulation of GTPase activity |
GO_0007165 | Biological process | signal transduction |
GO_1901888 | Biological process | regulation of cell junction assembly |
GO_0038180 | Biological process | nerve growth factor signaling pathway |
GO_0032486 | Biological process | Rap protein signal transduction |
GO_0071320 | Biological process | cellular response to cAMP |
GO_1990090 | Biological process | cellular response to nerve growth factor stimulus |
GO_0061028 | Biological process | establishment of endothelial barrier |
GO_0007399 | Biological process | nervous system development |
GO_0005886 | Cellular component | plasma membrane |
GO_0005769 | Cellular component | early endosome |
GO_0005829 | Cellular component | cytosol |
GO_0005737 | Cellular component | cytoplasm |
GO_0043231 | Cellular component | intracellular membrane-bounded organelle |
GO_0005085 | Molecular function | guanyl-nucleotide exchange factor activity |
GO_0005515 | Molecular function | protein binding |
GO_0017124 | Molecular function | SH3 domain binding |
Gene name | RAPGEF1 |
Protein name | Rap guanine nucleotide exchange factor 1 (CRK SH3-binding GNRP) (Guanine nucleotide-releasing factor 2) (Protein C3G) Truncated guanine nucleotide-releasing factor 2 Rap guanine nucleotide exchange factor 1 Guanine nucleotide-releasing factor 2 |
Synonyms | GRF2 |
Description | FUNCTION: Guanine nucleotide-releasing protein that binds to SH3 domain of CRK and GRB2/ASH. Transduces signals from CRK to activate RAS. Involved in cell branching and adhesion mediated by BCAR1-CRK-RAPGEF1 signaling and activation of RAP1 . Plays a role in the establishment of basal endothelial barrier function. Plays a role in nerve growth factor (NGF)-induced sustained activation of Rap1 and neurite outgrowth. . |
Accessions | ENST00000372189.7 [Q13905-1] A5XEI8 A5XEI5 A5XEI4 A0A804HL87 Q13905 A0A1S5UYZ7 A5XEJ1 A5XEI9 H0Y6R4 ENST00000414781.1 A5XEJ0 ENST00000438647.3 A5XEI7 Q5JUE9 ENST00000372190.8 [Q13905-3] ENST00000683357.1 A5XEI6 ENST00000372195.5 [Q13905-4] |