RAPGEF1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0007265Biological processRas protein signal transduction
GO_0007169Biological processcell surface receptor protein tyrosine kinase signaling pathway
GO_0010976Biological processpositive regulation of neuron projection development
GO_0043547Biological processpositive regulation of GTPase activity
GO_0007165Biological processsignal transduction
GO_1901888Biological processregulation of cell junction assembly
GO_0038180Biological processnerve growth factor signaling pathway
GO_0032486Biological processRap protein signal transduction
GO_0071320Biological processcellular response to cAMP
GO_1990090Biological processcellular response to nerve growth factor stimulus
GO_0061028Biological processestablishment of endothelial barrier
GO_0007399Biological processnervous system development
GO_0005886Cellular componentplasma membrane
GO_0005769Cellular componentearly endosome
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0043231Cellular componentintracellular membrane-bounded organelle
GO_0005085Molecular functionguanyl-nucleotide exchange factor activity
GO_0005515Molecular functionprotein binding
GO_0017124Molecular functionSH3 domain binding

IV. Literature review

[source]
Gene nameRAPGEF1
Protein nameRap guanine nucleotide exchange factor 1 (CRK SH3-binding GNRP) (Guanine nucleotide-releasing factor 2) (Protein C3G)
Truncated guanine nucleotide-releasing factor 2
Rap guanine nucleotide exchange factor 1
Guanine nucleotide-releasing factor 2
SynonymsGRF2
DescriptionFUNCTION: Guanine nucleotide-releasing protein that binds to SH3 domain of CRK and GRB2/ASH. Transduces signals from CRK to activate RAS. Involved in cell branching and adhesion mediated by BCAR1-CRK-RAPGEF1 signaling and activation of RAP1 . Plays a role in the establishment of basal endothelial barrier function. Plays a role in nerve growth factor (NGF)-induced sustained activation of Rap1 and neurite outgrowth. .

AccessionsENST00000372189.7 [Q13905-1]
A5XEI8
A5XEI5
A5XEI4
A0A804HL87
Q13905
A0A1S5UYZ7
A5XEJ1
A5XEI9
H0Y6R4
ENST00000414781.1
A5XEJ0
ENST00000438647.3
A5XEI7
Q5JUE9
ENST00000372190.8 [Q13905-3]
ENST00000683357.1
A5XEI6
ENST00000372195.5 [Q13905-4]