ARHGEF28 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0051056Biological processregulation of small GTPase mediated signal transduction
GO_0000902Biological processcell morphogenesis
GO_0048013Biological processephrin receptor signaling pathway
GO_0060052Biological processneurofilament cytoskeleton organization
GO_0035023Biological processregulation of Rho protein signal transduction
GO_0021955Biological processcentral nervous system neuron axonogenesis
GO_0005829Cellular componentcytosol
GO_0005886Cellular componentplasma membrane
GO_0005085Molecular functionguanyl-nucleotide exchange factor activity
GO_0046872Molecular functionmetal ion binding
GO_0003723Molecular functionRNA binding

IV. Literature review

[source]
Gene nameARHGEF28
Protein nameRho guanine nucleotide exchange factor 28
Rho guanine nucleotide exchange factor 28 (190 kDa guanine nucleotide exchange factor) (p190-RhoGEF) (p190RhoGEF) (Rho guanine nucleotide exchange factor)
ARHGEF28
SynonymsRGNEF
KIAA1998
DescriptionFUNCTION: Functions as a RHOA-specific guanine nucleotide exchange factor regulating signaling pathways downstream of integrins and growth factor receptors. Functions in axonal branching, synapse formation and dendritic morphogenesis. Functions also in focal adhesion formation, cell motility and B-lymphocytes activation. May regulate NEFL expression and aggregation and play a role in apoptosis (By similarity). .

AccessionsENST00000437974.5 [Q8N1W1-6]
D6RAP0
Q8N1W1
A0A2X0U2G7
ENST00000426542.6 [Q8N1W1-1]
ENST00000296799.8 [Q8N1W1-5]
ENST00000296794.10 [Q8N1W1-4]
ENST00000513042.7 [Q8N1W1-1]
ENST00000509848.5
ENST00000512883.1
ENST00000545377.5 [Q8N1W1-6]
D6RGZ3