GRIPAP1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0099158Biological processregulation of recycling endosome localization within postsynapse
GO_1905244Biological processregulation of modification of synaptic structure
GO_1903910Biological processnegative regulation of receptor clustering
GO_0008150Biological processbiological_process
GO_0098887Biological processneurotransmitter receptor transport, endosome to postsynaptic membrane
GO_0099152Biological processregulation of neurotransmitter receptor transport, endosome to postsynaptic membrane
GO_0098978Cellular componentglutamatergic synapse
GO_0098998Cellular componentextrinsic component of postsynaptic early endosome membrane
GO_0055038Cellular componentrecycling endosome membrane
GO_0005654Cellular componentnucleoplasm
GO_0043025Cellular componentneuronal cell body
GO_0042734Cellular componentpresynaptic membrane
GO_0030425Cellular componentdendrite
GO_0072562Cellular componentblood microparticle
GO_0098837Cellular componentpostsynaptic recycling endosome
GO_0005829Cellular componentcytosol
GO_0043231Cellular componentintracellular membrane-bounded organelle
GO_0030424Cellular componentaxon
GO_0005085Molecular functionguanyl-nucleotide exchange factor activity
GO_0042802Molecular functionidentical protein binding
GO_0035255Molecular functionionotropic glutamate receptor binding
GO_0005515Molecular functionprotein binding
GO_0003674Molecular functionmolecular_function

IV. Literature review

[source]
Gene nameGRIPAP1
Protein nameGRIP1 associated protein 1
GRIP1-associated protein 1 (GRASP-1) [Cleaved into: GRASP-1 C-terminal chain (30kDa C-terminus form)]
SynonymsKIAA1167
DescriptionFUNCTION: Regulates the endosomal recycling back to the neuronal plasma membrane, possibly by connecting early and late recycling endosomal domains and promoting segregation of recycling endosomes from early endosomal membranes. Involved in the localization of recycling endosomes to dendritic spines, thereby playing a role in the maintenance of dendritic spine morphology. Required for the activity-induced AMPA receptor recycling to dendrite membranes and for long-term potentiation and synaptic plasticity (By similarity). .; FUNCTION: [GRASP-1 C-terminal chain]: Functions as a scaffold protein to facilitate MAP3K1/MEKK1-mediated activation of the JNK1 kinase by phosphorylation, possibly by bringing MAP3K1/MEKK1 and JNK1 in close proximity. .

AccessionsA0A994J4V9
ENST00000703990.1
A0A994J4N3
A0A994J4D1
ENST00000704034.1
ENST00000704264.1
ENST00000703932.1
ENST00000704271.1
ENST00000611757.4 [Q4V328-2]
A0A087WXA6
ENST00000704107.1
A0A994J7N3
ENST00000704269.1
ENST00000703927.1
ENST00000376423.8 [Q4V328-1]
A0A994J472
ENST00000703876.1
A0A087WT45
A0A994J436
ENST00000622599.5
A0A994J745
ENST00000704038.1
ENST00000703859.1
A0A994J6U6
ENST00000704108.1
ENST00000703884.1
ENST00000703860.1
ENST00000704033.1
A0A087WWF2
ENST00000703906.1
A0A994J461
ENST00000704268.1
ENST00000703963.1
A0A994J783
A0A994J4X0
A0A994J6P1
A0A994J724
A0A994J4W7
ENST00000703926.1
ENST00000703989.1
A0A994J3Y7
A0A994J3X9
ENST00000703931.1
ENST00000703854.1
A0A994J489
ENST00000703881.1
ENST00000704098.1
ENST00000704029.1
A0A994J7B3
A0A994J6S6
ENST00000704021.1
A0A994J4H5
A0A994J6X0
ENST00000704106.1
ENST00000704045.1
ENST00000704022.1
ENST00000704044.1
A0A994J463
ENST00000704095.1
ENST00000704104.1
A0A994J4H0
ENST00000703855.1
ENST00000593475.6 [Q4V328-4]
ENST00000703883.1
A0A994J4F7
A0A994J452
A0A994J4M4
ENST00000703928.1
ENST00000710116.1 [Q4V328-4]
A0A994J772
A0A994J799
A0A994J484
A0A994J488
A0A994J6V9
ENST00000617369.5
ENST00000703995.1
ENST00000703994.1
A0A994J4E1
A0A994J4J8
ENST00000703862.1
A0A994J4A2
ENST00000704103.1
ENST00000710199.1 [Q4V328-2]
A0A994J6M6
ENST00000704105.1
ENST00000611705.5
ENST00000703882.1
ENST00000703930.1
ENST00000704028.1
A0A994J4U4
ENST00000704020.1
ENST00000703905.1
A0A994J417
ENST00000703929.1
A0A994J6Q0
A0A994J714
A0A087WW92
ENST00000704046.1
A0A994J446
ENST00000704267.1
ENST00000710115.1 [Q4V328-1]
ENST00000619107.2
A0A994J467
A0A994J6U0
ENST00000703880.1
Q4V328
ENST00000703962.1
A0A994J790
A0A994J4G1
A0A994J447
ENST00000703861.1
A0A994J7A3
ENST00000704018.1
ENST00000704017.1
ENST00000704272.1
ENST00000704047.1
A0A994J4B5
A0A994J4V2
ENST00000703988.1
ENST00000621664.2
ENST00000704265.1
A0A994J720
ENST00000704097.1