I. Expression across cell types
Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| epithelial cell | 4 studies | 25% ± 8% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| epithelial cell | 4 studies | 25% ± 8% |
Insufficient scRNA-seq data for expression of RGP1 at tissue level.
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| esophagus | 100% | 2312.38 | 1445 / 1445 | 100% | 17.73 | 183 / 183 |
| intestine | 100% | 2765.36 | 966 / 966 | 100% | 16.59 | 527 / 527 |
| stomach | 100% | 2129.24 | 359 / 359 | 100% | 17.13 | 286 / 286 |
| prostate | 100% | 1976.23 | 245 / 245 | 100% | 19.40 | 500 / 502 |
| breast | 100% | 1913.87 | 459 / 459 | 99% | 18.93 | 1110 / 1118 |
| thymus | 100% | 2517.35 | 653 / 653 | 99% | 17.35 | 600 / 605 |
| lung | 100% | 2194.95 | 578 / 578 | 99% | 15.46 | 1144 / 1155 |
| skin | 100% | 2261.91 | 1809 / 1809 | 99% | 16.16 | 467 / 472 |
| brain | 99% | 1348.46 | 2627 / 2642 | 99% | 16.33 | 701 / 705 |
| ovary | 100% | 2013.98 | 180 / 180 | 99% | 15.22 | 425 / 430 |
| kidney | 100% | 1999.73 | 89 / 89 | 98% | 15.87 | 885 / 901 |
| uterus | 100% | 2339.81 | 170 / 170 | 98% | 13.23 | 450 / 459 |
| pancreas | 100% | 1558.02 | 327 / 328 | 98% | 15.72 | 174 / 178 |
| bladder | 100% | 2091.38 | 21 / 21 | 95% | 11.74 | 479 / 504 |
| adrenal gland | 100% | 2596.60 | 258 / 258 | 95% | 13.74 | 218 / 230 |
| liver | 100% | 1025.86 | 225 / 226 | 86% | 7.25 | 351 / 406 |
| adipose | 100% | 1810.41 | 1204 / 1204 | 0% | 0 | 0 / 0 |
| blood vessel | 100% | 2263.34 | 1335 / 1335 | 0% | 0 | 0 / 0 |
| lymph node | 0% | 0 | 0 / 0 | 100% | 9.93 | 29 / 29 |
| muscle | 100% | 2592.22 | 803 / 803 | 0% | 0 | 0 / 0 |
| spleen | 100% | 1889.87 | 241 / 241 | 0% | 0 | 0 / 0 |
| tonsil | 0% | 0 | 0 / 0 | 100% | 15.85 | 45 / 45 |
| ureter | 0% | 0 | 0 / 0 | 100% | 5.00 | 1 / 1 |
| eye | 0% | 0 | 0 / 0 | 99% | 14.12 | 79 / 80 |
| heart | 98% | 1745.80 | 848 / 861 | 0% | 0 | 0 / 0 |
| peripheral blood | 95% | 1265.27 | 880 / 929 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| GO_0042147 | Biological process | retrograde transport, endosome to Golgi |
| GO_0042177 | Biological process | negative regulation of protein catabolic process |
| GO_0043547 | Biological process | positive regulation of GTPase activity |
| GO_0032588 | Cellular component | trans-Golgi network membrane |
| GO_0000139 | Cellular component | Golgi membrane |
| GO_0032991 | Cellular component | protein-containing complex |
| GO_0005829 | Cellular component | cytosol |
| GO_0005886 | Cellular component | plasma membrane |
| GO_0034066 | Cellular component | Ric1-Rgp1 guanyl-nucleotide exchange factor complex |
| GO_0016020 | Cellular component | membrane |
| GO_0005085 | Molecular function | guanyl-nucleotide exchange factor activity |
| GO_0005515 | Molecular function | protein binding |
| GO_0031267 | Molecular function | small GTPase binding |
| Gene name | RGP1 |
| Protein name | RAB6A-GEF complex partner protein 2 (Retrograde Golgi transport protein RGP1 homolog) |
| Synonyms | KIAA0258 |
| Description | FUNCTION: The RIC1-RGP1 complex acts as a guanine nucleotide exchange factor (GEF), which activates RAB6A by exchanging bound GDP for free GTP and may thereby required for efficient fusion of endosome-derived vesicles with the Golgi compartment. The RIC1-RGP1 complex participates in the recycling of mannose-6-phosphate receptors. . |
| Accessions | Q92546 ENST00000378078.5 |
