SWAP70 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0060754Biological processpositive regulation of mast cell chemotaxis
GO_0032233Biological processpositive regulation of actin filament bundle assembly
GO_0051056Biological processregulation of small GTPase mediated signal transduction
GO_0032880Biological processregulation of protein localization
GO_1902309Biological processnegative regulation of peptidyl-serine dephosphorylation
GO_0051017Biological processactin filament bundle assembly
GO_0007204Biological processpositive regulation of cytosolic calcium ion concentration
GO_0033633Biological processnegative regulation of cell-cell adhesion mediated by integrin
GO_0045190Biological processisotype switching
GO_0030835Biological processnegative regulation of actin filament depolymerization
GO_0005886Cellular componentplasma membrane
GO_0098794Cellular componentpostsynapse
GO_0015629Cellular componentactin cytoskeleton
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0030027Cellular componentlamellipodium
GO_0005634Cellular componentnucleus
GO_0003677Molecular functionDNA binding
GO_0005085Molecular functionguanyl-nucleotide exchange factor activity
GO_0045296Molecular functioncadherin binding
GO_0005524Molecular functionATP binding
GO_0005509Molecular functioncalcium ion binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameSWAP70
Protein nameSWAP-70 protein, isoform CRA_b (cDNA FLJ39540 fis, clone PUAEN2008314, highly similar to Switch-associated protein 70)
Switch-associated protein 70 (SWAP-70)
Switching B cell complex subunit SWAP70
SynonymshCG_23993
KIAA0640
HSPC321
DescriptionFUNCTION: Phosphatidylinositol 3,4,5-trisphosphate-dependent guanine nucleotide exchange factor (GEF) which, independently of RAS, transduces signals from tyrosine kinase receptors to RAC. It also mediates signaling of membrane ruffling. Regulates the actin cytoskeleton as an effector or adapter protein in response to agonist stimulated phosphatidylinositol (3,4)-bisphosphate production and cell protrusion (By similarity). .

AccessionsENST00000318950.11
ENST00000526358.5
B3KUB9
E7EMB1
E9PJK8
E9PJM7
H0YDK5
ENST00000534662.1
Q9UH65
ENST00000447399.6
ENST00000534562.1