I. Expression across cell types
Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| epithelial cell | 3 studies | 35% ± 20% | |
| brush cell | 3 studies | 21% ± 5% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| epithelial cell | 3 studies | 35% ± 20% | |
| brush cell | 3 studies | 21% ± 5% |
Insufficient scRNA-seq data for expression of ARHGEF5 at tissue level.
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| prostate | 100% | 1486.04 | 245 / 245 | 100% | 12.92 | 502 / 502 |
| pancreas | 99% | 777.83 | 325 / 328 | 99% | 12.64 | 177 / 178 |
| thymus | 100% | 2461.79 | 653 / 653 | 98% | 13.38 | 591 / 605 |
| intestine | 98% | 1046.27 | 948 / 966 | 99% | 14.03 | 523 / 527 |
| kidney | 100% | 1270.61 | 89 / 89 | 97% | 8.81 | 875 / 901 |
| lung | 98% | 783.28 | 565 / 578 | 99% | 14.62 | 1146 / 1155 |
| ovary | 94% | 469.83 | 170 / 180 | 99% | 10.37 | 427 / 430 |
| breast | 92% | 1068.64 | 420 / 459 | 99% | 11.24 | 1106 / 1118 |
| stomach | 85% | 750.39 | 306 / 359 | 98% | 12.15 | 281 / 286 |
| esophagus | 83% | 1203.55 | 1196 / 1445 | 99% | 20.48 | 181 / 183 |
| liver | 93% | 625.59 | 211 / 226 | 87% | 6.12 | 355 / 406 |
| uterus | 75% | 329.51 | 127 / 170 | 95% | 13.82 | 438 / 459 |
| skin | 90% | 2749.82 | 1625 / 1809 | 55% | 3.77 | 258 / 472 |
| bladder | 48% | 366.52 | 10 / 21 | 96% | 12.36 | 484 / 504 |
| tonsil | 0% | 0 | 0 / 0 | 100% | 18.97 | 45 / 45 |
| ureter | 0% | 0 | 0 / 0 | 100% | 6.05 | 1 / 1 |
| adrenal gland | 33% | 114.95 | 85 / 258 | 55% | 2.52 | 126 / 230 |
| eye | 0% | 0 | 0 / 0 | 84% | 3.85 | 67 / 80 |
| adipose | 80% | 350.85 | 960 / 1204 | 0% | 0 | 0 / 0 |
| spleen | 68% | 241.92 | 165 / 241 | 0% | 0 | 0 / 0 |
| blood vessel | 37% | 149.20 | 494 / 1335 | 0% | 0 | 0 / 0 |
| peripheral blood | 18% | 86.27 | 165 / 929 | 0% | 0 | 0 / 0 |
| heart | 15% | 51.51 | 133 / 861 | 0% | 0 | 0 / 0 |
| lymph node | 0% | 0 | 0 / 0 | 14% | 0.71 | 4 / 29 |
| brain | 6% | 20.48 | 157 / 2642 | 2% | 0.09 | 16 / 705 |
| muscle | 0% | 0.99 | 2 / 803 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| GO_0071803 | Biological process | positive regulation of podosome assembly |
| GO_0043507 | Biological process | positive regulation of JUN kinase activity |
| GO_0051091 | Biological process | positive regulation of DNA-binding transcription factor activity |
| GO_0070372 | Biological process | regulation of ERK1 and ERK2 cascade |
| GO_0051496 | Biological process | positive regulation of stress fiber assembly |
| GO_0090630 | Biological process | activation of GTPase activity |
| GO_0051493 | Biological process | regulation of cytoskeleton organization |
| GO_1904591 | Biological process | positive regulation of protein import |
| GO_0051056 | Biological process | regulation of small GTPase mediated signal transduction |
| GO_0061484 | Biological process | hematopoietic stem cell homeostasis |
| GO_0002408 | Biological process | myeloid dendritic cell chemotaxis |
| GO_0030036 | Biological process | actin cytoskeleton organization |
| GO_0035556 | Biological process | intracellular signal transduction |
| GO_0043087 | Biological process | regulation of GTPase activity |
| GO_0032956 | Biological process | regulation of actin cytoskeleton organization |
| GO_0005886 | Cellular component | plasma membrane |
| GO_0002102 | Cellular component | podosome |
| GO_0005654 | Cellular component | nucleoplasm |
| GO_0005829 | Cellular component | cytosol |
| GO_0071944 | Cellular component | cell periphery |
| GO_0070161 | Cellular component | anchoring junction |
| GO_0005737 | Cellular component | cytoplasm |
| GO_0042995 | Cellular component | cell projection |
| GO_0005634 | Cellular component | nucleus |
| GO_0005085 | Molecular function | guanyl-nucleotide exchange factor activity |
| GO_0008289 | Molecular function | lipid binding |
| GO_0005525 | Molecular function | GTP binding |
| GO_0005515 | Molecular function | protein binding |
| Gene name | ARHGEF5 |
| Protein name | ARHGEF5 (Rho guanine nucleotide exchange factor (GEF) 5) Rho guanine nucleotide exchange factor 5 Rho guanine nucleotide exchange factor (GEF) 5 Rho guanine nucleotide exchange factor 5 (Ephexin-3) (Guanine nucleotide regulatory protein TIM) (Oncogene TIM) (Transforming immortalized mammary oncogene) (p60 TIM) |
| Synonyms | TIM tcag7.492 |
| Description | FUNCTION: Guanine nucleotide exchange factor which activates Rho GTPases . Strongly activates RHOA . Also strongly activates RHOB, weakly activates RHOC and RHOG and shows no effect on RHOD, RHOV, RHOQ or RAC1 (By similarity). Involved in regulation of cell shape and actin cytoskeletal organization . Plays a role in actin organization by generating a loss of actin stress fibers and the formation of membrane ruffles and filopodia . Required for SRC-induced podosome formation (By similarity). Involved in positive regulation of immature dendritic cell migration (By similarity). . |
| Accessions | A0A090N7S2 ENST00000647153.2 ENST00000642803.2 ENST00000474817.5 C9J591 ENST00000056217.10 [Q12774-1] Q12774 H9XFB6 ENST00000471847.2 [Q12774-2] A0A2R8YF49 ENST00000498580.5 B9EGR7 H0Y895 |
