Name | Number of supported studies | Average coverage | |
---|---|---|---|
endothelial cell | 31 studies | 35% ± 16% | |
fibroblast | 18 studies | 28% ± 10% | |
pericyte | 12 studies | 22% ± 8% | |
oligodendrocyte | 11 studies | 34% ± 18% | |
macrophage | 11 studies | 27% ± 12% | |
smooth muscle cell | 10 studies | 22% ± 5% | |
ciliated cell | 9 studies | 24% ± 7% | |
capillary endothelial cell | 9 studies | 23% ± 10% | |
astrocyte | 9 studies | 39% ± 21% | |
adipocyte | 9 studies | 37% ± 11% | |
endothelial cell of lymphatic vessel | 8 studies | 31% ± 10% | |
basal cell | 8 studies | 27% ± 15% | |
glutamatergic neuron | 8 studies | 44% ± 20% | |
endothelial cell of artery | 8 studies | 24% ± 4% | |
oligodendrocyte precursor cell | 8 studies | 37% ± 19% | |
microglial cell | 8 studies | 35% ± 16% | |
epithelial cell | 8 studies | 34% ± 15% | |
GABAergic neuron | 7 studies | 36% ± 17% | |
CD16-negative, CD56-bright natural killer cell, human | 7 studies | 19% ± 3% | |
neuron | 7 studies | 36% ± 19% | |
amacrine cell | 7 studies | 27% ± 9% | |
B cell | 6 studies | 19% ± 4% | |
retina horizontal cell | 6 studies | 26% ± 11% | |
dendritic cell | 6 studies | 23% ± 5% | |
vein endothelial cell | 6 studies | 30% ± 13% | |
type I pneumocyte | 6 studies | 26% ± 9% | |
type II pneumocyte | 6 studies | 23% ± 6% | |
natural killer cell | 5 studies | 18% ± 2% | |
retinal rod cell | 5 studies | 22% ± 6% | |
interneuron | 5 studies | 55% ± 24% | |
cardiac muscle cell | 5 studies | 39% ± 8% | |
mesothelial cell | 5 studies | 24% ± 5% | |
plasma cell | 4 studies | 37% ± 12% | |
secretory cell | 4 studies | 24% ± 4% | |
abnormal cell | 4 studies | 29% ± 17% | |
granule cell | 4 studies | 30% ± 4% | |
retinal ganglion cell | 4 studies | 36% ± 11% | |
CD16-positive, CD56-dim natural killer cell, human | 4 studies | 17% ± 1% | |
myofibroblast cell | 4 studies | 30% ± 10% | |
lymphocyte | 4 studies | 25% ± 4% | |
myeloid cell | 4 studies | 26% ± 5% | |
respiratory goblet cell | 4 studies | 31% ± 11% | |
endothelial cell of vascular tree | 4 studies | 36% ± 14% | |
club cell | 4 studies | 29% ± 10% | |
erythrocyte | 4 studies | 42% ± 16% | |
goblet cell | 4 studies | 28% ± 14% | |
ionocyte | 3 studies | 22% ± 5% | |
CD4-positive, alpha-beta T cell | 3 studies | 17% ± 2% | |
effector memory CD8-positive, alpha-beta T cell | 3 studies | 19% ± 1% | |
plasmablast | 3 studies | 37% ± 9% | |
retinal bipolar neuron | 3 studies | 18% ± 3% | |
glial cell | 3 studies | 27% ± 3% | |
retinal cone cell | 3 studies | 24% ± 9% | |
GABAergic amacrine cell | 3 studies | 27% ± 12% | |
OFF-bipolar cell | 3 studies | 22% ± 7% | |
ON-bipolar cell | 3 studies | 24% ± 7% | |
glycinergic amacrine cell | 3 studies | 27% ± 3% | |
rod bipolar cell | 3 studies | 25% ± 6% | |
hepatocyte | 3 studies | 43% ± 17% | |
CD8-positive, alpha-beta T cell | 3 studies | 16% ± 1% | |
connective tissue cell | 3 studies | 23% ± 3% | |
T cell | 3 studies | 19% ± 3% | |
alveolar macrophage | 3 studies | 30% ± 9% | |
chondrocyte | 3 studies | 33% ± 13% | |
muscle cell | 3 studies | 32% ± 22% | |
transit amplifying cell | 3 studies | 41% ± 27% | |
brush cell | 3 studies | 24% ± 2% | |
plasmacytoid dendritic cell | 3 studies | 22% ± 7% | |
mucus secreting cell | 3 studies | 27% ± 10% | |
enteroendocrine cell | 3 studies | 23% ± 4% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
esophagus | 100% | 6822.75 | 1445 / 1445 | 100% | 18.85 | 183 / 183 |
brain | 100% | 6924.85 | 2639 / 2642 | 100% | 21.43 | 702 / 705 |
breast | 100% | 5547.11 | 459 / 459 | 99% | 13.92 | 1109 / 1118 |
thymus | 100% | 6904.12 | 653 / 653 | 99% | 14.24 | 600 / 605 |
skin | 100% | 5962.22 | 1809 / 1809 | 99% | 17.78 | 468 / 472 |
intestine | 100% | 8157.60 | 966 / 966 | 99% | 12.77 | 522 / 527 |
prostate | 100% | 5472.07 | 245 / 245 | 99% | 14.32 | 497 / 502 |
stomach | 100% | 5466.64 | 359 / 359 | 99% | 14.11 | 282 / 286 |
uterus | 100% | 7495.05 | 170 / 170 | 98% | 12.99 | 450 / 459 |
pancreas | 99% | 3285.44 | 325 / 328 | 98% | 11.11 | 175 / 178 |
kidney | 100% | 3965.27 | 89 / 89 | 97% | 10.37 | 875 / 901 |
bladder | 100% | 5866.33 | 21 / 21 | 97% | 10.31 | 489 / 504 |
lung | 100% | 5630.40 | 578 / 578 | 97% | 11.93 | 1120 / 1155 |
adrenal gland | 100% | 5921.99 | 258 / 258 | 94% | 14.02 | 217 / 230 |
ovary | 100% | 8286.98 | 180 / 180 | 88% | 7.52 | 380 / 430 |
liver | 99% | 2539.86 | 223 / 226 | 80% | 5.30 | 325 / 406 |
adipose | 100% | 5338.61 | 1204 / 1204 | 0% | 0 | 0 / 0 |
blood vessel | 100% | 6360.38 | 1335 / 1335 | 0% | 0 | 0 / 0 |
muscle | 100% | 7383.58 | 803 / 803 | 0% | 0 | 0 / 0 |
spleen | 100% | 5276.38 | 241 / 241 | 0% | 0 | 0 / 0 |
tonsil | 0% | 0 | 0 / 0 | 100% | 16.22 | 45 / 45 |
ureter | 0% | 0 | 0 / 0 | 100% | 3.84 | 1 / 1 |
eye | 0% | 0 | 0 / 0 | 99% | 18.26 | 79 / 80 |
heart | 98% | 5168.45 | 844 / 861 | 0% | 0 | 0 / 0 |
lymph node | 0% | 0 | 0 / 0 | 86% | 8.11 | 25 / 29 |
peripheral blood | 35% | 1494.00 | 327 / 929 | 0% | 0 | 0 / 0 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
GO_0016567 | Biological process | protein ubiquitination |
GO_0006281 | Biological process | DNA repair |
GO_0007283 | Biological process | spermatogenesis |
GO_0006974 | Biological process | DNA damage response |
GO_0006886 | Biological process | intracellular protein transport |
GO_0043161 | Biological process | proteasome-mediated ubiquitin-dependent protein catabolic process |
GO_0005886 | Cellular component | plasma membrane |
GO_0016020 | Cellular component | membrane |
GO_0005654 | Cellular component | nucleoplasm |
GO_0005814 | Cellular component | centriole |
GO_0005829 | Cellular component | cytosol |
GO_0005737 | Cellular component | cytoplasm |
GO_0005634 | Cellular component | nucleus |
GO_0061630 | Molecular function | ubiquitin protein ligase activity |
GO_0005085 | Molecular function | guanyl-nucleotide exchange factor activity |
GO_0031625 | Molecular function | ubiquitin protein ligase binding |
GO_0032183 | Molecular function | SUMO binding |
GO_0008270 | Molecular function | zinc ion binding |
GO_0005515 | Molecular function | protein binding |
Gene name | HERC2 |
Protein name | HECT and RLD domain containing E3 ubiquitin protein ligase 2 Alternative protein HERC2 HERC2 protein E3 ubiquitin-protein ligase HERC2 (EC 2.3.2.26) (HECT domain and RCC1-like domain-containing protein 2) (HECT-type E3 ubiquitin transferase HERC2) E3 ubiquitin-protein ligase HERC2 |
Synonyms | |
Description | FUNCTION: E3 ubiquitin-protein ligase that regulates ubiquitin-dependent retention of repair proteins on damaged chromosomes. Recruited to sites of DNA damage in response to ionizing radiation (IR) and facilitates the assembly of UBE2N and RNF8 promoting DNA damage-induced formation of 'Lys-63'-linked ubiquitin chains. Acts as a mediator of binding specificity between UBE2N and RNF8. Involved in the maintenance of RNF168 levels. E3 ubiquitin-protein ligase that promotes the ubiquitination and proteasomal degradation of XPA which influences the circadian oscillation of DNA excision repair activity. By controlling the steady-state expression of the IGF1R receptor, indirectly regulates the insulin-like growth factor receptor signaling pathway . Modulates also iron metabolism by regulating the basal turnover of FBXL5 . . |
Accessions | A0A3B3IRP6 ENST00000650509.1 ENST00000632916.1 ENST00000612410.1 O95714 L8E987 ENST00000620983.1 H3BRG9 ENST00000564734.5 A0A0J9YXQ8 L8E7P5 A0A0G2JLM1 ENST00000261609.13 A0A0G2JPS8 A0A0J9YVP0 ENST00000633685.1 ENST00000619734.4 H3BUQ1 A8KAQ8 ENST00000569772.1 |