HERC2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0016567Biological processprotein ubiquitination
GO_0006281Biological processDNA repair
GO_0007283Biological processspermatogenesis
GO_0006974Biological processDNA damage response
GO_0006886Biological processintracellular protein transport
GO_0043161Biological processproteasome-mediated ubiquitin-dependent protein catabolic process
GO_0005886Cellular componentplasma membrane
GO_0016020Cellular componentmembrane
GO_0005654Cellular componentnucleoplasm
GO_0005814Cellular componentcentriole
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0005634Cellular componentnucleus
GO_0061630Molecular functionubiquitin protein ligase activity
GO_0005085Molecular functionguanyl-nucleotide exchange factor activity
GO_0031625Molecular functionubiquitin protein ligase binding
GO_0032183Molecular functionSUMO binding
GO_0008270Molecular functionzinc ion binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameHERC2
Protein nameHECT and RLD domain containing E3 ubiquitin protein ligase 2
Alternative protein HERC2
HERC2 protein
E3 ubiquitin-protein ligase HERC2 (EC 2.3.2.26) (HECT domain and RCC1-like domain-containing protein 2) (HECT-type E3 ubiquitin transferase HERC2)
E3 ubiquitin-protein ligase HERC2
Synonyms
DescriptionFUNCTION: E3 ubiquitin-protein ligase that regulates ubiquitin-dependent retention of repair proteins on damaged chromosomes. Recruited to sites of DNA damage in response to ionizing radiation (IR) and facilitates the assembly of UBE2N and RNF8 promoting DNA damage-induced formation of 'Lys-63'-linked ubiquitin chains. Acts as a mediator of binding specificity between UBE2N and RNF8. Involved in the maintenance of RNF168 levels. E3 ubiquitin-protein ligase that promotes the ubiquitination and proteasomal degradation of XPA which influences the circadian oscillation of DNA excision repair activity. By controlling the steady-state expression of the IGF1R receptor, indirectly regulates the insulin-like growth factor receptor signaling pathway . Modulates also iron metabolism by regulating the basal turnover of FBXL5 . .

AccessionsA0A3B3IRP6
ENST00000650509.1
ENST00000632916.1
ENST00000612410.1
O95714
L8E987
ENST00000620983.1
H3BRG9
ENST00000564734.5
A0A0J9YXQ8
L8E7P5
A0A0G2JLM1
ENST00000261609.13
A0A0G2JPS8
A0A0J9YVP0
ENST00000633685.1
ENST00000619734.4
H3BUQ1
A8KAQ8
ENST00000569772.1