DENND1B report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0015031Biological processprotein transport
GO_2000553Biological processpositive regulation of T-helper 2 cell cytokine production
GO_0006897Biological processendocytosis
GO_0050852Biological processT cell receptor signaling pathway
GO_0032456Biological processendocytic recycling
GO_0050776Biological processregulation of immune response
GO_0043231Cellular componentintracellular membrane-bounded organelle
GO_0016607Cellular componentnuclear speck
GO_0005829Cellular componentcytosol
GO_0030136Cellular componentclathrin-coated vesicle
GO_0005085Molecular functionguanyl-nucleotide exchange factor activity
GO_1901981Molecular functionphosphatidylinositol phosphate binding
GO_0031267Molecular functionsmall GTPase binding

IV. Literature review

[source]
Gene nameDENND1B
Protein nameDENN domain containing 1B
DENN domain-containing protein 1B (Connecdenn 2) (Protein FAM31B)
DENND1B protein
Alternative protein DENND1B
DENN domain containing 1B (HCG2039668, isoform CRA_e) (cDNA FLJ33888 fis, clone CTONG2007417, moderately similar to DENN domain-containing protein 1A)
SynonymshCG_2039668
C1orf218
FAM31B
DescriptionFUNCTION: Guanine nucleotide exchange factor (GEF) for RAB35 that acts as a regulator of T-cell receptor (TCR) internalization in TH2 cells . Acts by promoting the exchange of GDP to GTP, converting inactive GDP-bound RAB35 into its active GTP-bound form . Plays a role in clathrin-mediated endocytosis . Controls cytokine production in TH2 lymphocytes by controlling the rate of TCR internalization and routing to endosomes: acts by mediating clathrin-mediated endocytosis of TCR via its interaction with the adapter protein complex 2 (AP-2) and GEF activity . Dysregulation leads to impaired TCR down-modulation and recycling, affecting cytokine production in TH2 cells . .

AccessionsB3KR95
ENST00000422998.1
L8EC82
Q6P3S1
ENST00000235453.8 [Q6P3S1-4]
ENST00000367396.7 [Q6P3S1-5]
B7ZBL5
ENST00000294737.11
ENST00000620048.6 [Q6P3S1-1]
Q96AX6