DIS3 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0006396Biological processRNA processing
GO_0071031Biological processnuclear mRNA surveillance of mRNA 3'-end processing
GO_0006401Biological processRNA catabolic process
GO_0016075Biological processrRNA catabolic process
GO_0071034Biological processCUT catabolic process
GO_0006364Biological processrRNA processing
GO_0005730Cellular componentnucleolus
GO_0000178Cellular componentexosome (RNase complex)
GO_0016020Cellular componentmembrane
GO_0005654Cellular componentnucleoplasm
GO_0000177Cellular componentcytoplasmic exosome (RNase complex)
GO_0005829Cellular componentcytosol
GO_0000176Cellular componentnuclear exosome (RNase complex)
GO_0005634Cellular componentnucleus
GO_0005085Molecular functionguanyl-nucleotide exchange factor activity
GO_0004519Molecular functionendonuclease activity
GO_0003723Molecular functionRNA binding
GO_0000175Molecular function3'-5'-RNA exonuclease activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameDIS3
Protein nameDIS3 homolog, exosome endoribonuclease and 3'-5' exoribonuclease
DIS3 protein
Exosome complex exonuclease RRP44 (EC 3.1.13.-) (EC 3.1.26.-) (Protein DIS3 homolog) (Ribosomal RNA-processing protein 44)
DIS3 homolog, exosome endoribonuclease and 3'-5' exoribonuclease (KIAA1008, isoform CRA_c)
SynonymshCG_32200
KIAA1008
RRP44
DescriptionFUNCTION: Putative catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. DIS3 has both 3'-5' exonuclease and endonuclease activities. .

AccessionsENST00000377767.9 [Q9Y2L1-1]
ENST00000490646.1
F2Z2C0
G3V1J5
Q49AG4
ENST00000377780.8 [Q9Y2L1-2]
ENST00000545453.5
Q9Y2L1