MCF2 | OmnibusX

Name	Number of supported studies	Average coverage
brain	3 studies	30% ± 7%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
brain	98%	650.07	2599 / 2642	71%	3.64	501 / 705
adrenal gland	100%	2354.98	258 / 258	37%	6.66	86 / 230
ovary	94%	496.58	169 / 180	0%	0.01	1 / 430
spleen	77%	116.62	185 / 241	0%	0	0 / 0
kidney	54%	79.94	48 / 89	8%	0.22	75 / 901
prostate	56%	102.43	138 / 245	4%	0.06	19 / 502
eye	0%	0	0 / 0	55%	5.29	44 / 80
blood vessel	43%	92.27	574 / 1335	0%	0	0 / 0
heart	32%	46.76	274 / 861	0%	0	0 / 0
thymus	21%	22.63	136 / 653	6%	0.14	35 / 605
skin	1%	0.56	10 / 1809	14%	0.94	66 / 472
lymph node	0%	0	0 / 0	10%	0.17	3 / 29
uterus	4%	5.01	6 / 170	6%	0.31	28 / 459
lung	3%	2.94	19 / 578	6%	0.18	69 / 1155
peripheral blood	8%	7.62	78 / 929	0%	0	0 / 0
bladder	5%	10.95	1 / 21	2%	0.08	10 / 504
esophagus	3%	2.63	38 / 1445	3%	0.28	6 / 183
intestine	6%	5.76	54 / 966	0%	0.01	1 / 527
stomach	4%	3.57	13 / 359	1%	0.01	2 / 286
pancreas	0%	0.21	1 / 328	2%	0.08	4 / 178
breast	0%	0.33	2 / 459	2%	0.05	22 / 1118
liver	1%	0.96	3 / 226	0%	0.02	2 / 406
adipose	1%	0.93	13 / 1204	0%	0	0 / 0
muscle	0%	0.44	4 / 803	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
tonsil	0%	0	0 / 0	0%	0	0 / 45
ureter	0%	0	0 / 0	0%	0	0 / 1

GO_0051056	Biological process	regulation of small GTPase mediated signal transduction
GO_1990830	Biological process	cellular response to leukemia inhibitory factor
GO_0035556	Biological process	intracellular signal transduction
GO_0050771	Biological process	negative regulation of axonogenesis
GO_0016358	Biological process	dendrite development
GO_0005856	Cellular component	cytoskeleton
GO_0005829	Cellular component	cytosol
GO_0019898	Cellular component	extrinsic component of membrane
GO_0016020	Cellular component	membrane
GO_0005737	Cellular component	cytoplasm
GO_0005085	Molecular function	guanyl-nucleotide exchange factor activity
GO_0005515	Molecular function	protein binding

Gene name	MCF2
Protein name	MCF.2 cell line derived transforming sequence MCF2 Proto-oncogene DBL (Proto-oncogene MCF-2) [Cleaved into: MCF2-transforming protein; DBL-transforming protein]
Synonyms	DBL
Description	FUNCTION: Guanine nucleotide exchange factor (GEF) that modulates the Rho family of GTPases. Promotes the conversion of some member of the Rho family GTPase from the GDP-bound to the GTP-bound form. Isoform 1 exhibits no activity toward RHOA, RAC1 or CDC42. Isoform 2 exhibits decreased GEF activity toward CDC42. Isoform 3 exhibits a weak but significant activity toward RAC1 and CDC42. Isoform 4 exhibits significant activity toward RHOA and CDC42. The truncated DBL oncogene is active toward RHOA, RAC1 and CDC42.
Accessions	ENST00000370573.8 [P10911-2] ENST00000414978.5 [P10911-3] ENST00000520602.6 ENST00000446225.5 ENST00000370576.9 [P10911-1] ENST00000519895.6 [P10911-5] Q5JYJ5 H0Y662 A0A2X0SZ10 ENST00000437564.5 ENST00000338585.6 [P10911-4] A0A2U3TZL4 P10911 ENST00000536274.5 [P10911-6]

MCF2 report