RASGRF2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0051056Biological processregulation of small GTPase mediated signal transduction
GO_0007265Biological processRas protein signal transduction
GO_0060291Biological processlong-term synaptic potentiation
GO_0034976Biological processresponse to endoplasmic reticulum stress
GO_0005783Cellular componentendoplasmic reticulum
GO_0005829Cellular componentcytosol
GO_0005886Cellular componentplasma membrane
GO_0005789Cellular componentendoplasmic reticulum membrane
GO_0005085Molecular functionguanyl-nucleotide exchange factor activity
GO_0005516Molecular functioncalmodulin binding

IV. Literature review

[source]
Gene nameRASGRF2
Protein nameRas protein specific guanine nucleotide releasing factor 2
RASGRF2
Ras-specific guanine nucleotide-releasing factor 2 (Ras-GRF2) (Ras guanine nucleotide exchange factor 2)
SynonymsGRF2
DescriptionFUNCTION: Functions as a calcium-regulated nucleotide exchange factor activating both Ras and RAC1 through the exchange of bound GDP for GTP. Preferentially activates HRAS in vivo compared to RRAS based on their different types of prenylation. Functions in synaptic plasticity by contributing to the induction of long term potentiation. .

AccessionsENST00000265080.9
ENST00000638442.1
D6RAS9
O14827
A0A2X0SFL3
A0A1W2PP99
ENST00000503795.1