RABGEF1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0007265Biological processRas protein signal transduction
GO_0043305Biological processnegative regulation of mast cell degranulation
GO_0038109Biological processKit signaling pathway
GO_0002686Biological processnegative regulation of leukocyte migration
GO_0006898Biological processreceptor-mediated endocytosis
GO_0097531Biological processmast cell migration
GO_0032715Biological processnegative regulation of interleukin-6 production
GO_0060368Biological processregulation of Fc receptor mediated stimulatory signaling pathway
GO_0006612Biological processprotein targeting to membrane
GO_1900235Biological processnegative regulation of Kit signaling pathway
GO_0046580Biological processnegative regulation of Ras protein signal transduction
GO_0043303Biological processmast cell degranulation
GO_0001933Biological processnegative regulation of protein phosphorylation
GO_0032764Biological processnegative regulation of mast cell cytokine production
GO_0050728Biological processnegative regulation of inflammatory response
GO_0098935Biological processdendritic transport
GO_0048261Biological processnegative regulation of receptor-mediated endocytosis
GO_0015031Biological processprotein transport
GO_0033004Biological processnegative regulation of mast cell activation
GO_0005730Cellular componentnucleolus
GO_0030139Cellular componentendocytic vesicle
GO_0055037Cellular componentrecycling endosome
GO_0005769Cellular componentearly endosome
GO_0031901Cellular componentearly endosome membrane
GO_0030425Cellular componentdendrite
GO_0005829Cellular componentcytosol
GO_0003677Molecular functionDNA binding
GO_0061630Molecular functionubiquitin protein ligase activity
GO_0005085Molecular functionguanyl-nucleotide exchange factor activity
GO_0031267Molecular functionsmall GTPase binding
GO_0008270Molecular functionzinc ion binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameRABGEF1
Protein nameRAB guanine nucleotide exchange factor 1
Rab5 GDP/GTP exchange factor (RAP1) (Rabaptin-5-associated exchange factor for Rab5) (Rabex-5)
SynonymsRABEX5
DescriptionFUNCTION: Rab effector protein acting as linker between gamma-adaptin, RAB4A or RAB5A. Involved in endocytic membrane fusion and membrane trafficking of recycling endosomes. Stimulates nucleotide exchange on RAB5A. Can act as a ubiquitin ligase (By similarity). .

AccessionsV9GYI8
ENST00000442563.5
ENST00000450873.6 [Q9UJ41-2]
ENST00000439720.3
Q9UJ41
A0A1W2PPY0
ENST00000484547.7
E9PFK9
ENST00000284957.9 [Q9UJ41-2]
ENST00000607882.5
C9JDA2