NUCB1 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
endothelial cell	35 studies	35% ± 16%	Explore
fibroblast	32 studies	31% ± 14%	Explore
macrophage	26 studies	32% ± 13%	Explore
natural killer cell	24 studies	29% ± 8%	Explore
pericyte	23 studies	29% ± 10%	Explore
non-classical monocyte	19 studies	34% ± 14%	Explore
CD8-positive, alpha-beta T cell	19 studies	26% ± 9%	Explore
classical monocyte	19 studies	30% ± 11%	Explore
CD4-positive, alpha-beta T cell	18 studies	26% ± 8%	Explore
T cell	16 studies	21% ± 4%	Explore
endothelial cell of lymphatic vessel	16 studies	39% ± 15%	Explore
smooth muscle cell	16 studies	27% ± 8%	Explore
plasmacytoid dendritic cell	16 studies	33% ± 13%	Explore
connective tissue cell	16 studies	31% ± 13%	Explore
regulatory T cell	16 studies	29% ± 10%	Explore
monocyte	15 studies	25% ± 7%	Explore
conventional dendritic cell	14 studies	28% ± 14%	Explore
CD16-positive, CD56-dim natural killer cell, human	14 studies	31% ± 9%	Explore
capillary endothelial cell	13 studies	31% ± 10%	Explore
mast cell	12 studies	20% ± 5%	Explore
myofibroblast cell	12 studies	30% ± 9%	Explore
vein endothelial cell	12 studies	37% ± 12%	Explore
CD16-negative, CD56-bright natural killer cell, human	11 studies	28% ± 5%	Explore
endothelial cell of artery	11 studies	40% ± 12%	Explore
gamma-delta T cell	11 studies	29% ± 6%	Explore
plasma cell	10 studies	35% ± 12%	Explore
B cell	10 studies	20% ± 5%	Explore
mature NK T cell	10 studies	26% ± 6%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	10 studies	23% ± 5%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	10 studies	26% ± 8%	Explore
epithelial cell	10 studies	39% ± 22%	Explore
basal cell	9 studies	29% ± 14%	Explore
mucosal invariant T cell	9 studies	27% ± 4%	Explore
endothelial cell of vascular tree	9 studies	35% ± 12%	Explore
alveolar macrophage	8 studies	35% ± 9%	Explore
type I pneumocyte	8 studies	29% ± 11%	Explore
CD4-positive, alpha-beta memory T cell	8 studies	31% ± 12%	Explore
CD8-positive, alpha-beta memory T cell	8 studies	28% ± 12%	Explore
type II pneumocyte	7 studies	31% ± 14%	Explore
plasmablast	7 studies	45% ± 24%	Explore
platelet	7 studies	25% ± 9%	Explore
myeloid cell	7 studies	33% ± 8%	Explore
memory B cell	7 studies	18% ± 3%	Explore
hematopoietic precursor cell	6 studies	26% ± 13%	Explore
effector memory CD8-positive, alpha-beta T cell	6 studies	27% ± 5%	Explore
epithelial cell of proximal tubule	6 studies	25% ± 10%	Explore
enterocyte	6 studies	31% ± 7%	Explore
abnormal cell	6 studies	31% ± 18%	Explore
hematopoietic stem cell	6 studies	27% ± 8%	Explore
ciliated cell	6 studies	26% ± 8%	Explore
dendritic cell	6 studies	38% ± 19%	Explore
T follicular helper cell	6 studies	20% ± 4%	Explore
mesothelial cell	5 studies	30% ± 18%	Explore
effector CD8-positive, alpha-beta T cell	5 studies	30% ± 11%	Explore
secretory cell	4 studies	28% ± 10%	Explore
pancreatic A cell	4 studies	48% ± 16%	Explore
exhausted T cell	4 studies	35% ± 9%	Explore
kidney distal convoluted tubule epithelial cell	4 studies	31% ± 9%	Explore
astrocyte	4 studies	24% ± 6%	Explore
adventitial cell	4 studies	35% ± 9%	Explore
effector CD4-positive, alpha-beta T cell	4 studies	43% ± 9%	Explore
effector memory CD4-positive, alpha-beta T cell	4 studies	37% ± 12%	Explore
enteroendocrine cell	4 studies	32% ± 16%	Explore
effector memory CD8-positive, alpha-beta T cell, terminally differentiated	4 studies	24% ± 8%	Explore
ionocyte	3 studies	22% ± 3%	Explore
respiratory goblet cell	3 studies	26% ± 13%	Explore
type B pancreatic cell	3 studies	30% ± 9%	Explore
glomerular endothelial cell	3 studies	28% ± 4%	Explore
podocyte	3 studies	50% ± 5%	Explore
progenitor cell	3 studies	28% ± 10%	Explore
neuron	3 studies	28% ± 8%	Explore
leukocyte	3 studies	19% ± 4%	Explore
retinal ganglion cell	3 studies	54% ± 25%	Explore
lymphocyte	3 studies	29% ± 4%	Explore
microglial cell	3 studies	25% ± 8%	Explore
intermediate monocyte	3 studies	45% ± 14%	Explore
myoepithelial cell	3 studies	30% ± 6%	Explore
muscle cell	3 studies	34% ± 20%	Explore
GABAergic neuron	3 studies	32% ± 12%	Explore
glutamatergic neuron	3 studies	38% ± 15%	Explore
pancreatic ductal cell	3 studies	45% ± 20%	Explore
oligodendrocyte precursor cell	3 studies	24% ± 7%	Explore
megakaryocyte	3 studies	29% ± 8%	Explore
goblet cell	3 studies	26% ± 8%	Explore
group 3 innate lymphoid cell	3 studies	28% ± 10%	Explore
naive B cell	3 studies	19% ± 5%	Explore
mononuclear phagocyte	3 studies	30% ± 17%	Explore
T-helper 1 cell	3 studies	30% ± 10%	Explore
innate lymphoid cell	3 studies	24% ± 6%	Explore
double negative thymocyte	3 studies	34% ± 5%	Explore
hepatocyte	3 studies	40% ± 21%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
lung	16 studies	26% ± 9%	Explore
peripheral blood	14 studies	28% ± 6%	Explore
intestine	9 studies	24% ± 11%	Explore
kidney	7 studies	25% ± 6%	Explore
brain	5 studies	26% ± 7%	Explore
liver	5 studies	23% ± 10%	Explore
pancreas	3 studies	41% ± 13%	Explore
placenta	3 studies	21% ± 3%	Explore
bone marrow	3 studies	20% ± 4%	Explore
uterus	3 studies	33% ± 10%	Explore
breast	3 studies	22% ± 1%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
adrenal gland	100%	13429.86	258 / 258	100%	274.07	230 / 230
esophagus	100%	14360.12	1445 / 1445	100%	189.17	183 / 183
liver	100%	24212.77	226 / 226	100%	306.72	406 / 406
ovary	100%	14347.49	180 / 180	100%	218.57	430 / 430
skin	100%	12783.05	1809 / 1809	100%	375.37	472 / 472
thymus	100%	17673.81	653 / 653	100%	288.99	605 / 605
uterus	100%	15319.98	170 / 170	100%	267.05	458 / 459
kidney	100%	20509.27	89 / 89	100%	317.66	899 / 901
pancreas	100%	6717.34	328 / 328	99%	271.13	177 / 178
prostate	100%	17352.53	245 / 245	99%	419.91	499 / 502
stomach	100%	12365.36	359 / 359	99%	201.97	284 / 286
intestine	100%	14449.30	966 / 966	99%	202.97	523 / 527
breast	100%	17617.59	459 / 459	99%	229.57	1106 / 1118
lung	100%	19731.51	578 / 578	99%	248.55	1142 / 1155
brain	99%	7014.99	2608 / 2642	100%	183.64	705 / 705
bladder	100%	16429.86	21 / 21	98%	251.77	495 / 504
adipose	100%	18736.32	1204 / 1204	0%	0	0 / 0
blood vessel	100%	22672.03	1335 / 1335	0%	0	0 / 0
eye	0%	0	0 / 0	100%	353.82	80 / 80
lymph node	0%	0	0 / 0	100%	232.97	29 / 29
spleen	100%	15495.00	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	245.30	45 / 45
ureter	0%	0	0 / 0	100%	193.22	1 / 1
muscle	100%	7775.43	802 / 803	0%	0	0 / 0
heart	100%	16654.18	859 / 861	0%	0	0 / 0
peripheral blood	100%	12024.49	925 / 929	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0007264	Biological process	small GTPase-mediated signal transduction
GO_0005615	Cellular component	extracellular space
GO_0005788	Cellular component	endoplasmic reticulum lumen
GO_0070062	Cellular component	extracellular exosome
GO_0005793	Cellular component	endoplasmic reticulum-Golgi intermediate compartment
GO_0005794	Cellular component	Golgi apparatus
GO_0016020	Cellular component	membrane
GO_0003677	Molecular function	DNA binding
GO_0005085	Molecular function	guanyl-nucleotide exchange factor activity
GO_0005509	Molecular function	calcium ion binding
GO_0001965	Molecular function	G-protein alpha-subunit binding
GO_0005515	Molecular function	protein binding

IV. Literature review

[source]

Gene name	NUCB1
Protein name	Nucleobindin-1 (CALNUC) Nucleobindin-1 Nucleobindin 1
Synonyms	NUC
Description	FUNCTION: Major calcium-binding protein of the Golgi which may have a role in calcium homeostasis (By similarity). Acts as a non-receptor guanine nucleotide exchange factor which binds to and activates alpha subunits of guanine nucleotide-binding proteins (G proteins) (By similarity). .
Accessions	ENST00000405315.9 C9JBD3 A0A9L9PXT8 ENST00000706760.1 ENST00000706752.1 ENST00000706746.1 ENST00000424608.2 ENST00000451312.6 A0A9L9PXW6 ENST00000706754.1 C9JKZ2 ENST00000407032.5 ENST00000411700.6 A0A9L9PXH6 A0A9L9PXH3 ENST00000706759.1 ENST00000706751.1 A0A9L9PYB5 ENST00000706758.1 ENST00000706757.1 A0A9L9PYB2 ENST00000706750.1 F8WB20 A0A9L9PXW3 ENST00000706755.1 ENST00000706753.1 A0A9L9PX96 A0A9L9PXA1 ENST00000706748.1 A0A9L9PXU2 H7BZI1 ENST00000706749.1 A0A9L9PXG8 Q02818 A0A9L9PYA9 ENST00000452087.6 ENST00000443560.1 C9J3C1

NUCB1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review