HERC1 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
endothelial cell	25 studies	47% ± 19%	Explore
oligodendrocyte	15 studies	40% ± 16%	Explore
astrocyte	15 studies	41% ± 16%	Explore
macrophage	14 studies	44% ± 21%	Explore
CD4-positive, alpha-beta T cell	14 studies	26% ± 10%	Explore
T cell	13 studies	32% ± 13%	Explore
CD8-positive, alpha-beta T cell	13 studies	24% ± 8%	Explore
microglial cell	13 studies	50% ± 11%	Explore
glutamatergic neuron	12 studies	69% ± 23%	Explore
oligodendrocyte precursor cell	12 studies	45% ± 17%	Explore
mast cell	12 studies	36% ± 16%	Explore
regulatory T cell	11 studies	24% ± 8%	Explore
fibroblast	11 studies	41% ± 12%	Explore
natural killer cell	10 studies	28% ± 11%	Explore
GABAergic neuron	10 studies	64% ± 23%	Explore
pericyte	10 studies	40% ± 16%	Explore
smooth muscle cell	10 studies	31% ± 11%	Explore
B cell	9 studies	31% ± 13%	Explore
CD16-positive, CD56-dim natural killer cell, human	9 studies	21% ± 7%	Explore
epithelial cell	9 studies	35% ± 18%	Explore
myeloid cell	9 studies	34% ± 13%	Explore
adipocyte	9 studies	44% ± 11%	Explore
CD8-positive, alpha-beta memory T cell	8 studies	21% ± 4%	Explore
CD16-negative, CD56-bright natural killer cell, human	8 studies	23% ± 10%	Explore
gamma-delta T cell	8 studies	23% ± 6%	Explore
mature NK T cell	7 studies	22% ± 11%	Explore
neuron	7 studies	55% ± 15%	Explore
amacrine cell	7 studies	35% ± 17%	Explore
retinal ganglion cell	7 studies	50% ± 21%	Explore
dendritic cell	7 studies	43% ± 11%	Explore
endothelial cell of lymphatic vessel	7 studies	42% ± 12%	Explore
CD4-positive, alpha-beta memory T cell	6 studies	19% ± 3%	Explore
effector memory CD8-positive, alpha-beta T cell	6 studies	30% ± 10%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	6 studies	25% ± 9%	Explore
non-classical monocyte	6 studies	23% ± 8%	Explore
interneuron	6 studies	65% ± 27%	Explore
naive B cell	6 studies	16% ± 1%	Explore
capillary endothelial cell	6 studies	26% ± 8%	Explore
basal cell	6 studies	37% ± 23%	Explore
type II pneumocyte	6 studies	35% ± 12%	Explore
retina horizontal cell	5 studies	41% ± 18%	Explore
cardiac muscle cell	5 studies	41% ± 10%	Explore
endothelial cell of artery	5 studies	22% ± 7%	Explore
monocyte	5 studies	45% ± 10%	Explore
leukocyte	5 studies	50% ± 20%	Explore
club cell	5 studies	33% ± 13%	Explore
type I pneumocyte	5 studies	37% ± 9%	Explore
granule cell	4 studies	56% ± 8%	Explore
mucosal invariant T cell	4 studies	27% ± 11%	Explore
ciliated cell	4 studies	24% ± 10%	Explore
lymphocyte	4 studies	48% ± 19%	Explore
Mueller cell	4 studies	29% ± 11%	Explore
OFF-bipolar cell	4 studies	36% ± 13%	Explore
ON-bipolar cell	4 studies	35% ± 14%	Explore
retinal cone cell	4 studies	35% ± 10%	Explore
retinal rod cell	4 studies	37% ± 6%	Explore
respiratory goblet cell	4 studies	30% ± 14%	Explore
endothelial cell of vascular tree	4 studies	39% ± 23%	Explore
erythrocyte	4 studies	52% ± 27%	Explore
plasmacytoid dendritic cell	4 studies	20% ± 6%	Explore
endothelial cell of sinusoid	3 studies	43% ± 16%	Explore
classical monocyte	3 studies	22% ± 5%	Explore
glial cell	3 studies	34% ± 6%	Explore
progenitor cell	3 studies	38% ± 7%	Explore
plasma cell	3 studies	34% ± 5%	Explore
mononuclear phagocyte	3 studies	31% ± 7%	Explore
vein endothelial cell	3 studies	45% ± 24%	Explore
retinal bipolar neuron	3 studies	31% ± 10%	Explore
GABAergic amacrine cell	3 studies	53% ± 12%	Explore
glycinergic amacrine cell	3 studies	46% ± 5%	Explore
rod bipolar cell	3 studies	36% ± 16%	Explore
effector memory CD4-positive, alpha-beta T cell	3 studies	22% ± 9%	Explore
hepatocyte	3 studies	57% ± 20%	Explore
retinal pigment epithelial cell	3 studies	47% ± 26%	Explore
connective tissue cell	3 studies	28% ± 9%	Explore
alveolar macrophage	3 studies	52% ± 11%	Explore
muscle cell	3 studies	36% ± 23%	Explore
goblet cell	3 studies	44% ± 32%	Explore
transit amplifying cell	3 studies	41% ± 33%	Explore
mesothelial cell	3 studies	35% ± 12%	Explore
mucus secreting cell	3 studies	34% ± 11%	Explore
enteroendocrine cell	3 studies	22% ± 4%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
brain	18 studies	51% ± 23%	Explore
lung	6 studies	31% ± 12%	Explore
eye	5 studies	46% ± 15%	Explore
liver	5 studies	29% ± 14%	Explore
peripheral blood	4 studies	23% ± 5%	Explore
heart	4 studies	38% ± 7%	Explore
intestine	3 studies	17% ± 0%	Explore
adipose	3 studies	43% ± 12%	Explore
kidney	3 studies	29% ± 6%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
esophagus	100%	5934.84	1445 / 1445	100%	14.57	183 / 183
thymus	100%	8170.21	653 / 653	100%	15.69	602 / 605
breast	100%	6666.22	459 / 459	99%	18.63	1107 / 1118
prostate	100%	5351.51	245 / 245	99%	13.92	496 / 502
brain	99%	7235.49	2624 / 2642	99%	18.99	701 / 705
skin	100%	5383.91	1808 / 1809	98%	15.23	464 / 472
stomach	100%	5380.91	359 / 359	98%	10.09	279 / 286
lung	100%	7482.07	578 / 578	97%	10.77	1126 / 1155
uterus	100%	7567.62	170 / 170	97%	9.57	445 / 459
kidney	100%	3978.01	89 / 89	97%	12.90	873 / 901
bladder	100%	5812.71	21 / 21	96%	8.21	486 / 504
pancreas	99%	3110.52	325 / 328	97%	10.62	173 / 178
adrenal gland	100%	4924.89	258 / 258	95%	12.82	219 / 230
intestine	100%	7310.40	966 / 966	95%	8.50	501 / 527
ovary	100%	7018.26	180 / 180	81%	5.34	349 / 430
liver	98%	2348.71	222 / 226	82%	6.22	333 / 406
adipose	100%	6804.93	1204 / 1204	0%	0	0 / 0
blood vessel	100%	5979.16	1335 / 1335	0%	0	0 / 0
lymph node	0%	0	0 / 0	100%	13.23	29 / 29
muscle	100%	9553.36	803 / 803	0%	0	0 / 0
spleen	100%	8525.55	241 / 241	0%	0	0 / 0
ureter	0%	0	0 / 0	100%	3.37	1 / 1
heart	99%	6061.03	854 / 861	0%	0	0 / 0
eye	0%	0	0 / 0	96%	9.59	77 / 80
peripheral blood	94%	4615.70	870 / 929	0%	0	0 / 0
tonsil	0%	0	0 / 0	93%	11.35	42 / 45
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0010507	Biological process	negative regulation of autophagy
GO_0016567	Biological process	protein ubiquitination
GO_0006914	Biological process	autophagy
GO_0022038	Biological process	corpus callosum development
GO_0050885	Biological process	neuromuscular process controlling balance
GO_0021702	Biological process	cerebellar Purkinje cell differentiation
GO_0031175	Biological process	neuron projection development
GO_0005829	Cellular component	cytosol
GO_0005794	Cellular component	Golgi apparatus
GO_0016020	Cellular component	membrane
GO_0005737	Cellular component	cytoplasm
GO_0004842	Molecular function	ubiquitin-protein transferase activity
GO_0005085	Molecular function	guanyl-nucleotide exchange factor activity

IV. Literature review

[source]

Gene name	HERC1
Protein name	Probable E3 ubiquitin-protein ligase HERC1 (EC 2.3.2.26) (HECT domain and RCC1-like domain-containing protein 1) (HECT-type E3 ubiquitin transferase HERC1) (p532) (p619) Alternative protein HERC1 HECT and RLD domain containing E3 ubiquitin protein ligase family member 1
Synonyms
Description	FUNCTION: Involved in membrane trafficking via some guanine nucleotide exchange factor (GEF) activity and its ability to bind clathrin. Acts as a GEF for Arf and Rab, by exchanging bound GDP for free GTP. Binds phosphatidylinositol 4,5-bisphosphate, which is required for GEF activity. May also act as a E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. .
Accessions	ENST00000561400.1 ENST00000560897.1 H0YKW7 H0YK45 ENST00000443617.7 H0YL74 L8E7Y5 ENST00000560462.1 ENST00000561359.1 H0YLG2 Q15751 ENST00000558532.1 H0YK60 H0YL07 ENST00000559715.1 ENST00000560316.1 ENST00000558324.1 H0YNB1 H0YMH0

HERC1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review