GBF1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0060271Biological processcilium assembly
GO_0090166Biological processGolgi disassembly
GO_0006890Biological processretrograde vesicle-mediated transport, Golgi to endoplasmic reticulum
GO_0097111Biological processendoplasmic reticulum-Golgi intermediate compartment organization
GO_0006892Biological processpost-Golgi vesicle-mediated transport
GO_0030593Biological processneutrophil chemotaxis
GO_2000008Biological processregulation of protein localization to cell surface
GO_0002263Biological processcell activation involved in immune response
GO_0034067Biological processprotein localization to Golgi apparatus
GO_0042147Biological processretrograde transport, endosome to Golgi
GO_0098586Biological processcellular response to virus
GO_0070973Biological processprotein localization to endoplasmic reticulum exit site
GO_0007030Biological processGolgi organization
GO_0032012Biological processregulation of ARF protein signal transduction
GO_1903409Biological processreactive oxygen species biosynthetic process
GO_1903420Biological processprotein localization to endoplasmic reticulum tubular network
GO_0007346Biological processregulation of mitotic cell cycle
GO_0015031Biological processprotein transport
GO_0006888Biological processendoplasmic reticulum to Golgi vesicle-mediated transport
GO_0048205Biological processCOPI coating of Golgi vesicle
GO_0061162Biological processestablishment of monopolar cell polarity
GO_0006895Biological processGolgi to endosome transport
GO_0005801Cellular componentcis-Golgi network
GO_0005811Cellular componentlipid droplet
GO_0016020Cellular componentmembrane
GO_0005794Cellular componentGolgi apparatus
GO_0031252Cellular componentcell leading edge
GO_0005802Cellular componenttrans-Golgi network
GO_0000139Cellular componentGolgi membrane
GO_0005829Cellular componentcytosol
GO_0005793Cellular componentendoplasmic reticulum-Golgi intermediate compartment
GO_0005085Molecular functionguanyl-nucleotide exchange factor activity
GO_0005547Molecular functionphosphatidylinositol-3,4,5-trisphosphate binding
GO_0080025Molecular functionphosphatidylinositol-3,5-bisphosphate binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameGBF1
Protein nameGolgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1 (BFA-resistant GEF 1)
Golgi brefeldin A resistant guanine nucleotide exchange factor 1
GBF1 protein
SynonymsKIAA0248
DescriptionFUNCTION: Guanine-nucleotide exchange factor (GEF) for members of the Arf family of small GTPases involved in trafficking in the early secretory pathway; its GEF activity initiates the coating of nascent vesicles via the localized generation of activated ARFs through replacement of GDP with GTP. Recruitment to cis-Golgi membranes requires membrane association of Arf-GDP and can be regulated by ARF1, ARF3, ARF4 and ARF5. Involved in the recruitment of the COPI coat complex to the endoplasmic reticulum exit sites (ERES), and the endoplasmic reticulum-Golgi intermediate (ERGIC) and cis-Golgi compartments which implicates ARF1 activation. Involved in COPI vesicle-dependent retrograde transport from the ERGIC and cis-Golgi compartments to the endoplasmic reticulum (ER) . Involved in the trans-Golgi network recruitment of GGA1, GGA2, GGA3, BIG1, BIG2, and the AP-1 adaptor protein complex related to chlathrin-dependent transport; the function requires its GEF activity (probably at least in part on ARF4 and ARF5) . Has GEF activity towards ARF1 . Has in vitro GEF activity towards ARF5 (By similarity). Involved in the processing of PSAP . Required for the assembly of the Golgi apparatus . The AMPK-phosphorylated form is involved in Golgi disassembly during mitotis and under stress conditions . May be involved in the COPI vesicle-dependent recruitment of PNPLA2 to lipid droplets; however, this function is under debate . In neutrophils, involved in G protein-coupled receptor (GPCR)-mediated chemotaxis und superoxide production. Proposed to be recruited by phosphatidylinositol-phosphates generated upon GPCR stimulation to the leading edge where it recruits and activates ARF1, and is involved in recruitment of GIT2 and the NADPH oxidase complex . Plays a role in maintaining mitochondrial morphology . .

AccessionsA0A7I2YQC6
ENST00000677247.1
Q92538
ENST00000369983.5 [Q92538-4]
A0A7I2V4E0
A0A7I2V2I0
ENST00000679155.1
ENST00000679087.1
ENST00000676985.1
A0A7I2YQE0
A0A7I2V6G3
ENST00000677100.1
A0A7I2V4W6
ENST00000679238.1
A0A7I2V2Z8
ENST00000676877.1
A0A7I2V5I9
A0A7I2V3E5
A0A7I2YQ62
A0A7I2V3H2
ENST00000677662.1
A0A7I2YQP6
ENST00000677871.1
ENST00000677098.1
A0A7I2V300
ENST00000679203.1
A0A7I2V4V3
A0A7I2V5Z2
ENST00000678293.1
A0A7I2V529
A0A7I2V4L8
ENST00000677522.1
A0A7I2YQC3
A0A7I2V2U1
ENST00000678319.1
A0A7I2V470
A0A7I2YQ65
A0A7I2YQM2
Q504U7
A0A7I2V4X4
ENST00000678504.1
A0A7I2YQJ5
ENST00000676682.1
ENST00000674034.1
A0A7I2V4F1
ENST00000678014.1
ENST00000676861.1
ENST00000678007.1
ENST00000676513.1 [Q92538-1]
A0A7I2V342
A0A7I2V3Y5
A0A7I2V336
ENST00000679288.1
ENST00000678036.1
ENST00000678575.1
A0A7I2V4F9
ENST00000678126.1
A0A7I2V2L5
A0A7I2V3R2
A0A7I2V4V8
A0A7I2V4M3
A0A7I2V4Z4
ENST00000676900.1
A0A7I2YQD3
A0A7I2V2L1
A0A7I2V5T8
A0A7I2V350
A0A7I2V3Q4
ENST00000677655.1
ENST00000676854.1
ENST00000677947.1
A0A669KB10
A0A7I2YQN3
Q05BW6
ENST00000676927.1
ENST00000677719.1
A0A7I2V338
ENST00000677017.1
A0A7I2V541
ENST00000676558.1
A0A7I2YQA6
ENST00000678476.1
ENST00000678351.1
ENST00000678722.1
ENST00000678530.1
A0A7I2V622
ENST00000679317.1
A0A7I2V2F8
A0A7I2V3A8
A0A7I2YQ79
A0A7I2V3B1
A0A7I2YQN6
ENST00000678604.1
ENST00000678453.1
A0A7I2V5C9
ENST00000677683.1
ENST00000678665.1
ENST00000679013.1
A0A7I2V305
ENST00000677439.1
A0A7I2V329
A0A7I2V4K2
ENST00000679305.1
ENST00000677618.1
ENST00000677240.1 [Q92538-2]
A0A7I2V6D0
ENST00000678292.1
ENST00000678127.1
ENST00000679084.1
A0A7I2V2G6
ENST00000677461.1
ENST00000676673.1
ENST00000678924.1
A0A7I2V4Q7
ENST00000676934.1
A0A7I2V4N7
ENST00000678571.1
A0A7I2V4N5
ENST00000676561.1
A0A7I2V3J0
A0A7I2V3Y7
ENST00000677269.1
A0A7I2YQB8
ENST00000676993.1 [Q92538-3]
ENST00000679186.1
A0A7I2V2L4
ENST00000679040.1
A0A7I2V4H1
A0A7I2V662
A0A7I2V528
A0A7I2V4M6
ENST00000677917.1
A0A669KBG8
ENST00000677838.1
A0A7I2V489
A0A7I2V5W2
ENST00000676482.1
ENST00000679093.1
ENST00000678923.1
A0A7I2V452
A0A7I2YQM0
A0A7I2V514
A0A7I2V5Z1
A0A7I2V578
A0A7I2V5V9
ENST00000677797.1
ENST00000678426.1
ENST00000677842.1
ENST00000676735.1
ENST00000676606.1
A0A7I2V2Y7
ENST00000676474.1
ENST00000678215.1
ENST00000677491.1
ENST00000678527.1
ENST00000677642.1
A0A7I2V2Q5
ENST00000677504.1
ENST00000673650.1
A0A7I2V2Q1
ENST00000678742.1
ENST00000676939.1 [Q92538-1]
ENST00000679253.1
ENST00000677776.1
A0A7I2V3S0
A0A7I2V306
ENST00000679080.1
ENST00000678558.1
A0A7I2V2Q6
ENST00000678806.1
ENST00000678344.1
ENST00000679139.1
A0A7I2V5S3
ENST00000677627.1