Name | Number of supported studies | Average coverage | |
---|---|---|---|
endothelial cell | 17 studies | 31% ± 13% | |
astrocyte | 13 studies | 34% ± 15% | |
oligodendrocyte precursor cell | 12 studies | 35% ± 14% | |
microglial cell | 10 studies | 28% ± 10% | |
fibroblast | 10 studies | 28% ± 9% | |
oligodendrocyte | 10 studies | 28% ± 10% | |
GABAergic neuron | 9 studies | 39% ± 23% | |
macrophage | 9 studies | 30% ± 11% | |
adipocyte | 9 studies | 37% ± 10% | |
glutamatergic neuron | 8 studies | 45% ± 25% | |
epithelial cell | 7 studies | 30% ± 15% | |
dendritic cell | 7 studies | 18% ± 2% | |
ciliated cell | 7 studies | 27% ± 12% | |
interneuron | 6 studies | 40% ± 22% | |
pericyte | 6 studies | 26% ± 9% | |
T cell | 6 studies | 21% ± 5% | |
endothelial cell of lymphatic vessel | 6 studies | 24% ± 7% | |
smooth muscle cell | 6 studies | 24% ± 7% | |
neuron | 5 studies | 41% ± 16% | |
plasma cell | 5 studies | 37% ± 14% | |
cardiac muscle cell | 5 studies | 45% ± 13% | |
club cell | 5 studies | 28% ± 10% | |
type I pneumocyte | 5 studies | 31% ± 7% | |
type II pneumocyte | 5 studies | 31% ± 6% | |
amacrine cell | 4 studies | 19% ± 2% | |
retinal cone cell | 4 studies | 40% ± 6% | |
retinal rod cell | 4 studies | 35% ± 5% | |
myeloid cell | 4 studies | 30% ± 5% | |
monocyte | 4 studies | 28% ± 8% | |
GABAergic interneuron | 3 studies | 28% ± 10% | |
granule cell | 3 studies | 27% ± 2% | |
retinal ganglion cell | 3 studies | 18% ± 2% | |
mast cell | 3 studies | 26% ± 8% | |
mesothelial cell | 3 studies | 24% ± 5% | |
mucosal invariant T cell | 3 studies | 18% ± 3% | |
GABAergic amacrine cell | 3 studies | 19% ± 3% | |
Mueller cell | 3 studies | 19% ± 2% | |
glycinergic amacrine cell | 3 studies | 20% ± 0% | |
retina horizontal cell | 3 studies | 19% ± 2% | |
endothelial cell of vascular tree | 3 studies | 26% ± 12% | |
hepatocyte | 3 studies | 46% ± 19% | |
retinal pigment epithelial cell | 3 studies | 28% ± 12% | |
connective tissue cell | 3 studies | 22% ± 4% | |
ependymal cell | 3 studies | 31% ± 15% | |
alveolar macrophage | 3 studies | 32% ± 8% | |
respiratory goblet cell | 3 studies | 35% ± 16% | |
lymphocyte | 3 studies | 34% ± 4% | |
goblet cell | 3 studies | 43% ± 32% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
esophagus | 100% | 6942.48 | 1445 / 1445 | 100% | 24.93 | 183 / 183 |
prostate | 100% | 8612.47 | 245 / 245 | 100% | 20.14 | 502 / 502 |
breast | 100% | 6933.17 | 459 / 459 | 100% | 19.62 | 1117 / 1118 |
thymus | 100% | 9339.53 | 653 / 653 | 100% | 17.41 | 603 / 605 |
lung | 100% | 7206.73 | 578 / 578 | 100% | 17.02 | 1151 / 1155 |
stomach | 100% | 5612.02 | 359 / 359 | 100% | 16.71 | 285 / 286 |
intestine | 100% | 7995.09 | 966 / 966 | 100% | 15.20 | 525 / 527 |
skin | 100% | 8186.96 | 1809 / 1809 | 100% | 16.28 | 470 / 472 |
bladder | 100% | 7230.14 | 21 / 21 | 99% | 12.72 | 501 / 504 |
uterus | 100% | 7944.47 | 170 / 170 | 99% | 13.58 | 456 / 459 |
pancreas | 100% | 4735.54 | 328 / 328 | 99% | 14.29 | 176 / 178 |
kidney | 100% | 6332.17 | 89 / 89 | 98% | 12.14 | 886 / 901 |
ovary | 100% | 6976.81 | 180 / 180 | 98% | 13.38 | 422 / 430 |
brain | 98% | 5142.71 | 2600 / 2642 | 99% | 15.54 | 699 / 705 |
adrenal gland | 100% | 6719.57 | 258 / 258 | 97% | 16.38 | 224 / 230 |
liver | 100% | 4101.81 | 226 / 226 | 94% | 8.89 | 380 / 406 |
adipose | 100% | 6271.17 | 1204 / 1204 | 0% | 0 | 0 / 0 |
blood vessel | 100% | 7277.59 | 1335 / 1335 | 0% | 0 | 0 / 0 |
eye | 0% | 0 | 0 / 0 | 100% | 14.88 | 80 / 80 |
lymph node | 0% | 0 | 0 / 0 | 100% | 12.81 | 29 / 29 |
muscle | 100% | 8984.20 | 803 / 803 | 0% | 0 | 0 / 0 |
spleen | 100% | 7247.66 | 241 / 241 | 0% | 0 | 0 / 0 |
tonsil | 0% | 0 | 0 / 0 | 100% | 15.74 | 45 / 45 |
ureter | 0% | 0 | 0 / 0 | 100% | 4.73 | 1 / 1 |
heart | 99% | 5784.39 | 849 / 861 | 0% | 0 | 0 / 0 |
peripheral blood | 94% | 3999.76 | 871 / 929 | 0% | 0 | 0 / 0 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
GO_0060271 | Biological process | cilium assembly |
GO_0090166 | Biological process | Golgi disassembly |
GO_0006890 | Biological process | retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum |
GO_0097111 | Biological process | endoplasmic reticulum-Golgi intermediate compartment organization |
GO_0006892 | Biological process | post-Golgi vesicle-mediated transport |
GO_0030593 | Biological process | neutrophil chemotaxis |
GO_2000008 | Biological process | regulation of protein localization to cell surface |
GO_0002263 | Biological process | cell activation involved in immune response |
GO_0034067 | Biological process | protein localization to Golgi apparatus |
GO_0042147 | Biological process | retrograde transport, endosome to Golgi |
GO_0098586 | Biological process | cellular response to virus |
GO_0070973 | Biological process | protein localization to endoplasmic reticulum exit site |
GO_0007030 | Biological process | Golgi organization |
GO_0032012 | Biological process | regulation of ARF protein signal transduction |
GO_1903409 | Biological process | reactive oxygen species biosynthetic process |
GO_1903420 | Biological process | protein localization to endoplasmic reticulum tubular network |
GO_0007346 | Biological process | regulation of mitotic cell cycle |
GO_0015031 | Biological process | protein transport |
GO_0006888 | Biological process | endoplasmic reticulum to Golgi vesicle-mediated transport |
GO_0048205 | Biological process | COPI coating of Golgi vesicle |
GO_0061162 | Biological process | establishment of monopolar cell polarity |
GO_0006895 | Biological process | Golgi to endosome transport |
GO_0005801 | Cellular component | cis-Golgi network |
GO_0005811 | Cellular component | lipid droplet |
GO_0016020 | Cellular component | membrane |
GO_0005794 | Cellular component | Golgi apparatus |
GO_0031252 | Cellular component | cell leading edge |
GO_0005802 | Cellular component | trans-Golgi network |
GO_0000139 | Cellular component | Golgi membrane |
GO_0005829 | Cellular component | cytosol |
GO_0005793 | Cellular component | endoplasmic reticulum-Golgi intermediate compartment |
GO_0005085 | Molecular function | guanyl-nucleotide exchange factor activity |
GO_0005547 | Molecular function | phosphatidylinositol-3,4,5-trisphosphate binding |
GO_0080025 | Molecular function | phosphatidylinositol-3,5-bisphosphate binding |
GO_0005515 | Molecular function | protein binding |
Gene name | GBF1 |
Protein name | Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1 (BFA-resistant GEF 1) Golgi brefeldin A resistant guanine nucleotide exchange factor 1 GBF1 protein |
Synonyms | KIAA0248 |
Description | FUNCTION: Guanine-nucleotide exchange factor (GEF) for members of the Arf family of small GTPases involved in trafficking in the early secretory pathway; its GEF activity initiates the coating of nascent vesicles via the localized generation of activated ARFs through replacement of GDP with GTP. Recruitment to cis-Golgi membranes requires membrane association of Arf-GDP and can be regulated by ARF1, ARF3, ARF4 and ARF5. Involved in the recruitment of the COPI coat complex to the endoplasmic reticulum exit sites (ERES), and the endoplasmic reticulum-Golgi intermediate (ERGIC) and cis-Golgi compartments which implicates ARF1 activation. Involved in COPI vesicle-dependent retrograde transport from the ERGIC and cis-Golgi compartments to the endoplasmic reticulum (ER) . Involved in the trans-Golgi network recruitment of GGA1, GGA2, GGA3, BIG1, BIG2, and the AP-1 adaptor protein complex related to chlathrin-dependent transport; the function requires its GEF activity (probably at least in part on ARF4 and ARF5) . Has GEF activity towards ARF1 . Has in vitro GEF activity towards ARF5 (By similarity). Involved in the processing of PSAP . Required for the assembly of the Golgi apparatus . The AMPK-phosphorylated form is involved in Golgi disassembly during mitotis and under stress conditions . May be involved in the COPI vesicle-dependent recruitment of PNPLA2 to lipid droplets; however, this function is under debate . In neutrophils, involved in G protein-coupled receptor (GPCR)-mediated chemotaxis und superoxide production. Proposed to be recruited by phosphatidylinositol-phosphates generated upon GPCR stimulation to the leading edge where it recruits and activates ARF1, and is involved in recruitment of GIT2 and the NADPH oxidase complex . Plays a role in maintaining mitochondrial morphology . . |
Accessions | A0A7I2YQC6 ENST00000677247.1 Q92538 ENST00000369983.5 [Q92538-4] A0A7I2V4E0 A0A7I2V2I0 ENST00000679155.1 ENST00000679087.1 ENST00000676985.1 A0A7I2YQE0 A0A7I2V6G3 ENST00000677100.1 A0A7I2V4W6 ENST00000679238.1 A0A7I2V2Z8 ENST00000676877.1 A0A7I2V5I9 A0A7I2V3E5 A0A7I2YQ62 A0A7I2V3H2 ENST00000677662.1 A0A7I2YQP6 ENST00000677871.1 ENST00000677098.1 A0A7I2V300 ENST00000679203.1 A0A7I2V4V3 A0A7I2V5Z2 ENST00000678293.1 A0A7I2V529 A0A7I2V4L8 ENST00000677522.1 A0A7I2YQC3 A0A7I2V2U1 ENST00000678319.1 A0A7I2V470 A0A7I2YQ65 A0A7I2YQM2 Q504U7 A0A7I2V4X4 ENST00000678504.1 A0A7I2YQJ5 ENST00000676682.1 ENST00000674034.1 A0A7I2V4F1 ENST00000678014.1 ENST00000676861.1 ENST00000678007.1 ENST00000676513.1 [Q92538-1] A0A7I2V342 A0A7I2V3Y5 A0A7I2V336 ENST00000679288.1 ENST00000678036.1 ENST00000678575.1 A0A7I2V4F9 ENST00000678126.1 A0A7I2V2L5 A0A7I2V3R2 A0A7I2V4V8 A0A7I2V4M3 A0A7I2V4Z4 ENST00000676900.1 A0A7I2YQD3 A0A7I2V2L1 A0A7I2V5T8 A0A7I2V350 A0A7I2V3Q4 ENST00000677655.1 ENST00000676854.1 ENST00000677947.1 A0A669KB10 A0A7I2YQN3 Q05BW6 ENST00000676927.1 ENST00000677719.1 A0A7I2V338 ENST00000677017.1 A0A7I2V541 ENST00000676558.1 A0A7I2YQA6 ENST00000678476.1 ENST00000678351.1 ENST00000678722.1 ENST00000678530.1 A0A7I2V622 ENST00000679317.1 A0A7I2V2F8 A0A7I2V3A8 A0A7I2YQ79 A0A7I2V3B1 A0A7I2YQN6 ENST00000678604.1 ENST00000678453.1 A0A7I2V5C9 ENST00000677683.1 ENST00000678665.1 ENST00000679013.1 A0A7I2V305 ENST00000677439.1 A0A7I2V329 A0A7I2V4K2 ENST00000679305.1 ENST00000677618.1 ENST00000677240.1 [Q92538-2] A0A7I2V6D0 ENST00000678292.1 ENST00000678127.1 ENST00000679084.1 A0A7I2V2G6 ENST00000677461.1 ENST00000676673.1 ENST00000678924.1 A0A7I2V4Q7 ENST00000676934.1 A0A7I2V4N7 ENST00000678571.1 A0A7I2V4N5 ENST00000676561.1 A0A7I2V3J0 A0A7I2V3Y7 ENST00000677269.1 A0A7I2YQB8 ENST00000676993.1 [Q92538-3] ENST00000679186.1 A0A7I2V2L4 ENST00000679040.1 A0A7I2V4H1 A0A7I2V662 A0A7I2V528 A0A7I2V4M6 ENST00000677917.1 A0A669KBG8 ENST00000677838.1 A0A7I2V489 A0A7I2V5W2 ENST00000676482.1 ENST00000679093.1 ENST00000678923.1 A0A7I2V452 A0A7I2YQM0 A0A7I2V514 A0A7I2V5Z1 A0A7I2V578 A0A7I2V5V9 ENST00000677797.1 ENST00000678426.1 ENST00000677842.1 ENST00000676735.1 ENST00000676606.1 A0A7I2V2Y7 ENST00000676474.1 ENST00000678215.1 ENST00000677491.1 ENST00000678527.1 ENST00000677642.1 A0A7I2V2Q5 ENST00000677504.1 ENST00000673650.1 A0A7I2V2Q1 ENST00000678742.1 ENST00000676939.1 [Q92538-1] ENST00000679253.1 ENST00000677776.1 A0A7I2V3S0 A0A7I2V306 ENST00000679080.1 ENST00000678558.1 A0A7I2V2Q6 ENST00000678806.1 ENST00000678344.1 ENST00000679139.1 A0A7I2V5S3 ENST00000677627.1 |