ARHGEF18 | OmnibusX

Name	Number of supported studies	Average coverage
oligodendrocyte	4 studies	27% ± 11%	Explore
astrocyte	3 studies	32% ± 14%	Explore

Name	Number of supported studies	Average coverage
brain	3 studies	40% ± 7%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
esophagus	100%	3473.96	1445 / 1445	100%	19.02	183 / 183
pancreas	100%	2892.27	328 / 328	100%	31.06	178 / 178
stomach	100%	4505.83	359 / 359	100%	19.59	286 / 286
uterus	100%	4083.45	170 / 170	100%	22.47	459 / 459
skin	100%	2970.11	1808 / 1809	100%	21.42	472 / 472
brain	100%	2516.73	2638 / 2642	100%	20.40	705 / 705
thymus	100%	2935.43	653 / 653	100%	23.43	604 / 605
intestine	100%	6275.34	966 / 966	100%	21.62	526 / 527
liver	100%	1660.76	226 / 226	100%	16.46	405 / 406
kidney	100%	4201.73	89 / 89	100%	14.61	898 / 901
breast	100%	2159.51	459 / 459	100%	17.11	1114 / 1118
ovary	100%	2413.50	180 / 180	100%	11.72	428 / 430
lung	100%	3874.20	576 / 578	100%	18.34	1153 / 1155
bladder	100%	3612.81	21 / 21	99%	25.71	501 / 504
prostate	100%	3651.20	245 / 245	99%	16.18	499 / 502
adrenal gland	100%	3919.16	258 / 258	99%	15.41	228 / 230
adipose	100%	2027.89	1204 / 1204	0%	0	0 / 0
eye	0%	0	0 / 0	100%	19.72	80 / 80
lymph node	0%	0	0 / 0	100%	37.34	29 / 29
spleen	100%	9331.06	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	21.33	45 / 45
ureter	0%	0	0 / 0	100%	22.40	1 / 1
blood vessel	100%	2289.32	1333 / 1335	0%	0	0 / 0
peripheral blood	98%	4517.27	913 / 929	0%	0	0 / 0
heart	92%	1004.62	794 / 861	0%	0	0 / 0
muscle	76%	667.37	609 / 803	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

GO_0008360	Biological process	regulation of cell shape
GO_0030036	Biological process	actin cytoskeleton organization
GO_0150105	Biological process	protein localization to cell-cell junction
GO_0051497	Biological process	negative regulation of stress fiber assembly
GO_0035023	Biological process	regulation of Rho protein signal transduction
GO_0007264	Biological process	small GTPase-mediated signal transduction
GO_0016324	Cellular component	apical plasma membrane
GO_0030054	Cellular component	cell junction
GO_0070062	Cellular component	extracellular exosome
GO_0005856	Cellular component	cytoskeleton
GO_0005829	Cellular component	cytosol
GO_0045177	Cellular component	apical part of cell
GO_0005886	Cellular component	plasma membrane
GO_0005085	Molecular function	guanyl-nucleotide exchange factor activity
GO_0005515	Molecular function	protein binding
GO_0046872	Molecular function	metal ion binding

Gene name	ARHGEF18
Protein name	Rho/Rac guanine nucleotide exchange factor 18 Rho guanine nucleotide exchange factor 18 ARHGEF18 Rho guanine nucleotide exchange factor 18 (114 kDa Rho-specific guanine nucleotide exchange factor) (p114-Rho-GEF) (p114RhoGEF) (Septin-associated RhoGEF) (SA-RhoGEF)
Synonyms	KIAA0521
Description	FUNCTION: Acts as a guanine nucleotide exchange factor (GEF) for RhoA GTPases. Its activation induces formation of actin stress fibers. Also acts as a GEF for RAC1, inducing production of reactive oxygen species (ROS). Does not act as a GEF for CDC42. The G protein beta-gamma (Gbetagamma) subunits of heterotrimeric G proteins act as activators, explaining the integrated effects of LPA and other G-protein coupled receptor agonists on actin stress fiber formation, cell shape change and ROS production. Required for EPB41L4B-mediated regulation of the circumferential actomyosin belt in epithelial cells . .
Accessions	ENST00000594665 ENST00000617428 ENST00000668164 A0A804CAZ4 ENST00000617428.4 [Q6ZSZ5-2] ENST00000359920.11 A0A2X0SSI0 ENST00000671891.2 ENST00000319670.14 Q6ZSZ5 M0QZS0 A0A087WZG4 A0A5F9ZHI8 A0A3B3IPE9 ENST00000594665.2 [Q6ZSZ5-2] ENST00000668164.2 [Q6ZSZ5-4] A0A590UK10

ARHGEF18 report