ARFGEF3 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0032012Biological processregulation of ARF protein signal transduction
GO_0005794Cellular componentGolgi apparatus
GO_0030658Cellular componenttransport vesicle membrane
GO_0005085Molecular functionguanyl-nucleotide exchange factor activity

IV. Literature review

[source]
Gene nameARFGEF3
Protein nameBrefeldin A-inhibited guanine nucleotide-exchange protein 3 (ARFGEF family member 3)
KIAA1244
SynonymsBIG3
KIAA1244
C6orf92
DescriptionFUNCTION: Participates in the regulation of systemic glucose homeostasis, where it negatively regulates insulin granule biogenesis in pancreatic islet beta cells (By similarity). Also regulates glucagon granule production in pancreatic alpha cells (By similarity). Inhibits nuclear translocation of the transcriptional coregulator PHB2 and may enhance estrogen receptor alpha (ESR1) transcriptional activity in breast cancer cells . .

AccessionsQ5TH69
ENST00000251691.5
B5MDV5