I. Expression across cell types
Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| glutamatergic neuron | 9 studies | 42% ± 24% | |
| hepatocyte | 3 studies | 39% ± 21% | |
| GABAergic neuron | 3 studies | 23% ± 3% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| glutamatergic neuron | 9 studies | 42% ± 24% | |
| hepatocyte | 3 studies | 39% ± 21% | |
| GABAergic neuron | 3 studies | 23% ± 3% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| brain | 4 studies | 44% ± 17% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| liver | 100% | 2257.83 | 226 / 226 | 98% | 21.96 | 399 / 406 |
| brain | 77% | 8697.49 | 2029 / 2642 | 89% | 31.68 | 624 / 705 |
| pancreas | 60% | 318.20 | 196 / 328 | 87% | 14.39 | 155 / 178 |
| kidney | 78% | 645.84 | 69 / 89 | 68% | 8.71 | 616 / 901 |
| stomach | 58% | 470.44 | 207 / 359 | 85% | 13.38 | 243 / 286 |
| adrenal gland | 100% | 5094.60 | 257 / 258 | 41% | 19.27 | 95 / 230 |
| intestine | 44% | 1034.98 | 426 / 966 | 94% | 16.75 | 498 / 527 |
| uterus | 71% | 649.32 | 121 / 170 | 62% | 7.64 | 284 / 459 |
| esophagus | 37% | 449.26 | 532 / 1445 | 85% | 10.47 | 155 / 183 |
| bladder | 29% | 122.05 | 6 / 21 | 67% | 8.23 | 340 / 504 |
| ovary | 12% | 51.97 | 21 / 180 | 81% | 12.64 | 348 / 430 |
| skin | 72% | 1470.83 | 1303 / 1809 | 12% | 4.67 | 58 / 472 |
| thymus | 2% | 13.57 | 15 / 653 | 79% | 27.12 | 476 / 605 |
| breast | 17% | 88.10 | 77 / 459 | 57% | 4.40 | 638 / 1118 |
| lung | 3% | 14.59 | 17 / 578 | 68% | 7.36 | 787 / 1155 |
| tonsil | 0% | 0 | 0 / 0 | 53% | 6.75 | 24 / 45 |
| blood vessel | 35% | 223.47 | 461 / 1335 | 0% | 0 | 0 / 0 |
| prostate | 5% | 23.65 | 13 / 245 | 19% | 1.05 | 93 / 502 |
| heart | 7% | 34.52 | 62 / 861 | 0% | 0 | 0 / 0 |
| adipose | 6% | 32.02 | 75 / 1204 | 0% | 0 | 0 / 0 |
| lymph node | 0% | 0 | 0 / 0 | 3% | 0.18 | 1 / 29 |
| muscle | 1% | 3.87 | 7 / 803 | 0% | 0 | 0 / 0 |
| spleen | 1% | 4.00 | 2 / 241 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 80 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| peripheral blood | 0% | 0 | 0 / 929 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
| GO_0051056 | Biological process | regulation of small GTPase mediated signal transduction |
| GO_0061002 | Biological process | negative regulation of dendritic spine morphogenesis |
| GO_0048013 | Biological process | ephrin receptor signaling pathway |
| GO_0043087 | Biological process | regulation of GTPase activity |
| GO_0030154 | Biological process | cell differentiation |
| GO_0007399 | Biological process | nervous system development |
| GO_0090630 | Biological process | activation of GTPase activity |
| GO_0005829 | Cellular component | cytosol |
| GO_0030426 | Cellular component | growth cone |
| GO_0016020 | Cellular component | membrane |
| GO_0005085 | Molecular function | guanyl-nucleotide exchange factor activity |
| GO_0005515 | Molecular function | protein binding |
| Gene name | NGEF |
| Protein name | NGEF Ephexin-1 (Eph-interacting exchange protein) (Neuronal guanine nucleotide exchange factor) Neuronal guanine nucleotide exchange factor |
| Synonyms | |
| Description | FUNCTION: Acts as a guanine nucleotide exchange factor (GEF) which differentially activates the GTPases RHOA, RAC1 and CDC42. Plays a role in axon guidance regulating ephrin-induced growth cone collapse and dendritic spine morphogenesis. Upon activation by ephrin through EPHA4, the GEF activity switches toward RHOA resulting in its activation. Activated RHOA promotes cone retraction at the expense of RAC1- and CDC42-stimulated growth cone extension (By similarity). . |
| Accessions | H7BZ39 A0A2X0SG27 C9JTV7 ENST00000424488.5 ENST00000414326.1 ENST00000264051.8 [Q8N5V2-1] ENST00000409079.1 [Q8N5V2-2] ENST00000373552.8 [Q8N5V2-3] H7C2C2 Q8N5V2 ENST00000416114.3 |
