CYTH2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0030036Biological processactin cytoskeleton organization
GO_0032012Biological processregulation of ARF protein signal transduction
GO_0006897Biological processendocytosis
GO_0000139Cellular componentGolgi membrane
GO_0005829Cellular componentcytosol
GO_0005912Cellular componentadherens junction
GO_0030426Cellular componentgrowth cone
GO_0005886Cellular componentplasma membrane
GO_0016020Cellular componentmembrane
GO_0005737Cellular componentcytoplasm
GO_0005923Cellular componentbicellular tight junction
GO_0070679Molecular functioninositol 1,4,5 trisphosphate binding
GO_0005085Molecular functionguanyl-nucleotide exchange factor activity
GO_0005515Molecular functionprotein binding
GO_0008289Molecular functionlipid binding

IV. Literature review

[source]
Gene nameCYTH2
Protein nameCytohesin-2 (PH, SEC7 and coiled-coil domain-containing protein 2)
Cytohesin 2
Cytohesin-2 (ARF exchange factor) (ARF nucleotide-binding site opener) (Protein ARNO) (PH, SEC7 and coiled-coil domain-containing protein 2)
Cytohesin 2 (Pleckstrin homology, Sec7 and coiled-coil domains 2 (Cytohesin-2), isoform CRA_c)
SynonymshCG_1998017
ARNO
PSCD2
PSCD2L
DescriptionFUNCTION: Acts as a guanine-nucleotide exchange factor (GEF). Promotes guanine-nucleotide exchange on ARF1, ARF3 and ARF6. Activates ARF factors through replacement of GDP with GTP (By similarity). The cell membrane form, in association with ARL4 proteins, recruits ARF6 to the plasma membrane . Involved in neurite growth (By similarity). .

AccessionsENST00000325139.9
ENST00000595765.2
ENST00000391881.7
A0A0D9SFG6
A0A286YF81
A0A994J5E5
Q99418
ENST00000641098.1 [Q99418-1]
ENST00000427476.4
ENST00000452733.7 [Q99418-2]
ENST00000704950.1
G5E9B7
F8W8E2
M0R2J0
ENST00000460595.5