BCR | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
endothelial cell	19 studies	25% ± 10%	Explore
astrocyte	11 studies	37% ± 15%	Explore
oligodendrocyte precursor cell	7 studies	38% ± 14%	Explore
epithelial cell	6 studies	25% ± 9%	Explore
endothelial cell of lymphatic vessel	6 studies	31% ± 9%	Explore
type I pneumocyte	6 studies	20% ± 5%	Explore
glutamatergic neuron	5 studies	36% ± 20%	Explore
adipocyte	5 studies	21% ± 2%	Explore
GABAergic neuron	5 studies	34% ± 15%	Explore
interneuron	4 studies	31% ± 19%	Explore
mesothelial cell	3 studies	21% ± 3%	Explore
ciliated cell	3 studies	19% ± 5%	Explore
endothelial cell of vascular tree	3 studies	33% ± 14%	Explore
cholangiocyte	3 studies	36% ± 27%	Explore
natural killer cell	3 studies	18% ± 1%	Explore
club cell	3 studies	18% ± 3%	Explore
basal cell	3 studies	26% ± 7%	Explore
goblet cell	3 studies	25% ± 8%	Explore
vein endothelial cell	3 studies	40% ± 23%	Explore
neuron	3 studies	27% ± 9%	Explore
oligodendrocyte	3 studies	18% ± 2%	Explore
endothelial cell of artery	3 studies	25% ± 8%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
brain	6 studies	31% ± 12%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
esophagus	100%	4990.70	1445 / 1445	100%	36.23	183 / 183
uterus	100%	3941.98	170 / 170	100%	30.94	458 / 459
brain	100%	9529.53	2640 / 2642	99%	59.80	700 / 705
thymus	100%	7166.11	653 / 653	99%	37.63	600 / 605
lung	100%	6160.90	577 / 578	99%	32.18	1144 / 1155
prostate	100%	4223.04	245 / 245	98%	19.73	494 / 502
breast	100%	5822.79	459 / 459	98%	24.04	1100 / 1118
intestine	100%	3619.10	966 / 966	98%	23.30	517 / 527
stomach	100%	4224.31	359 / 359	98%	23.21	280 / 286
bladder	100%	3952.57	21 / 21	96%	23.63	486 / 504
kidney	100%	6601.49	89 / 89	96%	18.41	868 / 901
ovary	100%	3053.37	180 / 180	95%	22.24	410 / 430
pancreas	96%	2119.71	314 / 328	98%	30.08	174 / 178
skin	100%	5459.59	1807 / 1809	93%	17.27	438 / 472
adrenal gland	100%	3612.57	258 / 258	90%	15.92	207 / 230
liver	97%	2404.04	219 / 226	90%	12.87	366 / 406
adipose	100%	6250.18	1204 / 1204	0%	0	0 / 0
eye	0%	0	0 / 0	100%	21.74	80 / 80
spleen	100%	4225.43	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	35.96	45 / 45
ureter	0%	0	0 / 0	100%	18.48	1 / 1
blood vessel	100%	6472.48	1334 / 1335	0%	0	0 / 0
heart	95%	2615.61	816 / 861	0%	0	0 / 0
lymph node	0%	0	0 / 0	93%	18.82	27 / 29
peripheral blood	87%	2672.26	812 / 929	0%	0	0 / 0
muscle	42%	668.01	341 / 803	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0030216	Biological process	keratinocyte differentiation
GO_0050766	Biological process	positive regulation of phagocytosis
GO_0003014	Biological process	renal system process
GO_0050804	Biological process	modulation of chemical synaptic transmission
GO_0090630	Biological process	activation of GTPase activity
GO_0043114	Biological process	regulation of vascular permeability
GO_0007165	Biological process	signal transduction
GO_0051056	Biological process	regulation of small GTPase mediated signal transduction
GO_0065002	Biological process	intracellular protein transmembrane transport
GO_0050885	Biological process	neuromuscular process controlling balance
GO_0060313	Biological process	negative regulation of blood vessel remodeling
GO_2000378	Biological process	negative regulation of reactive oxygen species metabolic process
GO_0048872	Biological process	homeostasis of number of cells
GO_0030036	Biological process	actin cytoskeleton organization
GO_0060216	Biological process	definitive hemopoiesis
GO_0050728	Biological process	negative regulation of inflammatory response
GO_0043312	Biological process	neutrophil degranulation
GO_0035023	Biological process	regulation of Rho protein signal transduction
GO_0007264	Biological process	small GTPase-mediated signal transduction
GO_1905517	Biological process	macrophage migration
GO_1905522	Biological process	negative regulation of macrophage migration
GO_0002692	Biological process	negative regulation of cellular extravasation
GO_0006909	Biological process	phagocytosis
GO_0043314	Biological process	negative regulation of neutrophil degranulation
GO_0048041	Biological process	focal adhesion assembly
GO_0042472	Biological process	inner ear morphogenesis
GO_0007420	Biological process	brain development
GO_0071222	Biological process	cellular response to lipopolysaccharide
GO_0006468	Biological process	protein phosphorylation
GO_0060268	Biological process	negative regulation of respiratory burst
GO_0051726	Biological process	regulation of cell cycle
GO_0098978	Cellular component	glutamatergic synapse
GO_0098685	Cellular component	Schaffer collateral - CA1 synapse
GO_0005886	Cellular component	plasma membrane
GO_0043197	Cellular component	dendritic spine
GO_0016020	Cellular component	membrane
GO_0070062	Cellular component	extracellular exosome
GO_0032991	Cellular component	protein-containing complex
GO_0005829	Cellular component	cytosol
GO_0014069	Cellular component	postsynaptic density
GO_0030424	Cellular component	axon
GO_0005085	Molecular function	guanyl-nucleotide exchange factor activity
GO_0106310	Molecular function	protein serine kinase activity
GO_0004713	Molecular function	protein tyrosine kinase activity
GO_0004674	Molecular function	protein serine/threonine kinase activity
GO_0005096	Molecular function	GTPase activator activity
GO_0005524	Molecular function	ATP binding
GO_0005515	Molecular function	protein binding

IV. Literature review

[source]

Gene name	BCR
Protein name	Breakpoint cluster region protein BCR BCR activator of RhoGEF and GTPase Breakpoint cluster region protein (EC 2.7.11.1) (Renal carcinoma antigen NY-REN-26) BCR protein F-box domain-containing protein
Synonyms	BCR1 D22S11
Description	FUNCTION: Protein with a unique structure having two opposing regulatory activities toward small GTP-binding proteins. The C-terminus is a GTPase-activating protein (GAP) domain which stimulates GTP hydrolysis by RAC1, RAC2 and CDC42. Accelerates the intrinsic rate of GTP hydrolysis of RAC1 or CDC42, leading to down-regulation of the active GTP-bound form . The central Dbl homology (DH) domain functions as guanine nucleotide exchange factor (GEF) that modulates the GTPases CDC42, RHOA and RAC1. Promotes the conversion of CDC42, RHOA and RAC1 from the GDP-bound to the GTP-bound form . The amino terminus contains an intrinsic kinase activity . Functions as an important negative regulator of neuronal RAC1 activity (By similarity). Regulates macrophage functions such as CSF1-directed motility and phagocytosis through the modulation of RAC1 activity . Plays a major role as a RHOA GEF in keratinocytes being involved in focal adhesion formation and keratinocyte differentiation . .
Accessions	Q6QJE8 Q6QJE5 Q12844 Q6QJE4 H0Y554 Q6QJE7 Q6QJE3 P11274 ENST00000359540.7 [P11274-2] Q12843 Q5XJ20 A0A2X0SFQ7 Q6QJE6 Q6QJE9 Q12845 ENST00000427791.1 ENST00000305877.13 [P11274-1]

BCR report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review