Name | Number of supported studies | Average coverage | |
---|---|---|---|
endothelial cell | 35 studies | 50% ± 25% | |
macrophage | 23 studies | 48% ± 25% | |
astrocyte | 19 studies | 70% ± 21% | |
microglial cell | 17 studies | 83% ± 22% | |
oligodendrocyte | 16 studies | 74% ± 17% | |
fibroblast | 14 studies | 42% ± 18% | |
oligodendrocyte precursor cell | 14 studies | 62% ± 16% | |
glutamatergic neuron | 13 studies | 65% ± 22% | |
GABAergic neuron | 11 studies | 60% ± 16% | |
myeloid cell | 10 studies | 48% ± 20% | |
capillary endothelial cell | 9 studies | 37% ± 25% | |
endothelial cell of lymphatic vessel | 9 studies | 47% ± 18% | |
type I pneumocyte | 8 studies | 56% ± 27% | |
pericyte | 8 studies | 34% ± 18% | |
vein endothelial cell | 7 studies | 53% ± 30% | |
neuron | 6 studies | 66% ± 18% | |
interneuron | 6 studies | 69% ± 12% | |
retina horizontal cell | 6 studies | 59% ± 30% | |
monocyte | 6 studies | 42% ± 19% | |
ciliated cell | 6 studies | 47% ± 24% | |
cardiac muscle cell | 5 studies | 37% ± 13% | |
endothelial cell of artery | 5 studies | 50% ± 27% | |
mesothelial cell | 5 studies | 45% ± 19% | |
endothelial cell of vascular tree | 5 studies | 47% ± 22% | |
club cell | 5 studies | 42% ± 16% | |
type II pneumocyte | 5 studies | 31% ± 8% | |
smooth muscle cell | 4 studies | 36% ± 7% | |
granule cell | 4 studies | 70% ± 14% | |
dendritic cell | 4 studies | 45% ± 7% | |
retinal rod cell | 4 studies | 24% ± 3% | |
endothelial cell of sinusoid | 3 studies | 46% ± 6% | |
glomerular endothelial cell | 3 studies | 30% ± 1% | |
differentiation-committed oligodendrocyte precursor | 3 studies | 71% ± 10% | |
GABAergic interneuron | 3 studies | 55% ± 16% | |
epithelial cell | 3 studies | 37% ± 14% | |
glial cell | 3 studies | 44% ± 14% | |
progenitor cell | 3 studies | 50% ± 3% | |
adipocyte | 3 studies | 20% ± 3% | |
tissue-resident macrophage | 3 studies | 33% ± 21% | |
GABAergic amacrine cell | 3 studies | 60% ± 22% | |
amacrine cell | 3 studies | 59% ± 12% | |
glycinergic amacrine cell | 3 studies | 57% ± 17% | |
retinal cone cell | 3 studies | 23% ± 6% | |
hepatocyte | 3 studies | 71% ± 22% | |
connective tissue cell | 3 studies | 23% ± 7% | |
ependymal cell | 3 studies | 51% ± 14% | |
adventitial cell | 3 studies | 32% ± 15% | |
alveolar macrophage | 3 studies | 69% ± 9% | |
myofibroblast cell | 3 studies | 36% ± 17% | |
respiratory goblet cell | 3 studies | 39% ± 15% | |
basal cell | 3 studies | 31% ± 5% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
brain | 100% | 4798.11 | 2642 / 2642 | 100% | 22.52 | 704 / 705 |
prostate | 100% | 1777.61 | 244 / 245 | 97% | 8.74 | 486 / 502 |
kidney | 100% | 1604.88 | 89 / 89 | 94% | 11.11 | 850 / 901 |
lung | 100% | 7621.96 | 578 / 578 | 91% | 6.49 | 1050 / 1155 |
breast | 100% | 2405.36 | 459 / 459 | 90% | 6.39 | 1009 / 1118 |
liver | 100% | 1592.37 | 226 / 226 | 88% | 4.78 | 357 / 406 |
esophagus | 96% | 1348.80 | 1393 / 1445 | 87% | 5.02 | 160 / 183 |
thymus | 100% | 1740.08 | 652 / 653 | 75% | 3.57 | 451 / 605 |
ovary | 100% | 2510.82 | 180 / 180 | 74% | 3.63 | 319 / 430 |
adrenal gland | 100% | 1349.26 | 257 / 258 | 67% | 3.19 | 154 / 230 |
skin | 87% | 867.78 | 1579 / 1809 | 79% | 7.28 | 371 / 472 |
pancreas | 79% | 658.74 | 259 / 328 | 83% | 3.94 | 148 / 178 |
uterus | 100% | 2290.39 | 170 / 170 | 49% | 2.13 | 224 / 459 |
intestine | 95% | 1264.28 | 915 / 966 | 53% | 2.23 | 281 / 527 |
stomach | 76% | 756.47 | 272 / 359 | 66% | 3.53 | 189 / 286 |
bladder | 95% | 1238.52 | 20 / 21 | 46% | 2.29 | 234 / 504 |
adipose | 100% | 2930.42 | 1204 / 1204 | 0% | 0 | 0 / 0 |
heart | 98% | 1264.61 | 842 / 861 | 0% | 0 | 0 / 0 |
blood vessel | 87% | 1125.56 | 1165 / 1335 | 0% | 0 | 0 / 0 |
muscle | 82% | 796.08 | 659 / 803 | 0% | 0 | 0 / 0 |
spleen | 76% | 607.72 | 183 / 241 | 0% | 0 | 0 / 0 |
tonsil | 0% | 0 | 0 / 0 | 69% | 3.51 | 31 / 45 |
lymph node | 0% | 0 | 0 / 0 | 52% | 2.69 | 15 / 29 |
peripheral blood | 41% | 434.99 | 378 / 929 | 0% | 0 | 0 / 0 |
eye | 0% | 0 | 0 / 0 | 18% | 0.55 | 14 / 80 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
GO_1904694 | Biological process | negative regulation of vascular associated smooth muscle contraction |
GO_0007264 | Biological process | small GTPase-mediated signal transduction |
GO_0060326 | Biological process | cell chemotaxis |
GO_1904754 | Biological process | positive regulation of vascular associated smooth muscle cell migration |
GO_0005730 | Cellular component | nucleolus |
GO_0032420 | Cellular component | stereocilium |
GO_0005886 | Cellular component | plasma membrane |
GO_0016020 | Cellular component | membrane |
GO_0005794 | Cellular component | Golgi apparatus |
GO_0032421 | Cellular component | stereocilium bundle |
GO_0005829 | Cellular component | cytosol |
GO_0005737 | Cellular component | cytoplasm |
GO_0005085 | Molecular function | guanyl-nucleotide exchange factor activity |
GO_0031267 | Molecular function | small GTPase binding |
GO_0005096 | Molecular function | GTPase activator activity |
GO_0030165 | Molecular function | PDZ domain binding |
GO_0005515 | Molecular function | protein binding |
GO_0030971 | Molecular function | receptor tyrosine kinase binding |
GO_0017124 | Molecular function | SH3 domain binding |
Gene name | DOCK4 |
Protein name | Uncharacterized protein DOCK4 DOCK4 protein DOCK4 Dedicator of cytokinesis 4 Dedicator of cytokinesis protein 4 |
Synonyms | KIAA0716 tcag7.1008 |
Description | FUNCTION: Functions as a guanine nucleotide exchange factor (GEF) that promotes the exchange of GDP to GTP, converting inactive GDP-bound small GTPases into their active GTP-bound form . Involved in regulation of adherens junction between cells . Plays a role in cell migration . .; FUNCTION: [Isoform 2]: Has a higher guanine nucleotide exchange factor activity compared to other isoforms. . |
Accessions | A4D0S8 ENST00000658652.1 ENST00000450156.6 A0A590UJM5 ENST00000437129.5 ENST00000445943.5 A0A590UJ51 Q149N6 H0Y7H7 ENST00000437633.6 [Q8N1I0-1] F8WES4 H0Y599 Q149N2 Q8N1I0 ENST00000423057.6 ENST00000417165.1 ENST00000428084.6 [Q8N1I0-3] ENST00000664131.1 C9J637 C9J7D9 C9JDB3 A0A2X0SFR8 ENST00000428053.5 Q75MU6 Q149N5 |