DOCK4 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_1904694Biological processnegative regulation of vascular associated smooth muscle contraction
GO_0007264Biological processsmall GTPase-mediated signal transduction
GO_0060326Biological processcell chemotaxis
GO_1904754Biological processpositive regulation of vascular associated smooth muscle cell migration
GO_0005730Cellular componentnucleolus
GO_0032420Cellular componentstereocilium
GO_0005886Cellular componentplasma membrane
GO_0016020Cellular componentmembrane
GO_0005794Cellular componentGolgi apparatus
GO_0032421Cellular componentstereocilium bundle
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0005085Molecular functionguanyl-nucleotide exchange factor activity
GO_0031267Molecular functionsmall GTPase binding
GO_0005096Molecular functionGTPase activator activity
GO_0030165Molecular functionPDZ domain binding
GO_0005515Molecular functionprotein binding
GO_0030971Molecular functionreceptor tyrosine kinase binding
GO_0017124Molecular functionSH3 domain binding

IV. Literature review

[source]
Gene nameDOCK4
Protein nameUncharacterized protein DOCK4
DOCK4 protein
DOCK4
Dedicator of cytokinesis 4
Dedicator of cytokinesis protein 4
SynonymsKIAA0716
tcag7.1008
DescriptionFUNCTION: Functions as a guanine nucleotide exchange factor (GEF) that promotes the exchange of GDP to GTP, converting inactive GDP-bound small GTPases into their active GTP-bound form . Involved in regulation of adherens junction between cells . Plays a role in cell migration . .; FUNCTION: [Isoform 2]: Has a higher guanine nucleotide exchange factor activity compared to other isoforms. .

AccessionsA4D0S8
ENST00000658652.1
ENST00000450156.6
A0A590UJM5
ENST00000437129.5
ENST00000445943.5
A0A590UJ51
Q149N6
H0Y7H7
ENST00000437633.6 [Q8N1I0-1]
F8WES4
H0Y599
Q149N2
Q8N1I0
ENST00000423057.6
ENST00000417165.1
ENST00000428084.6 [Q8N1I0-3]
ENST00000664131.1
C9J637
C9J7D9
C9JDB3
A0A2X0SFR8
ENST00000428053.5
Q75MU6
Q149N5