DEF6 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
natural killer cell	26 studies	25% ± 8%	Explore
CD4-positive, alpha-beta T cell	25 studies	25% ± 9%	Explore
CD8-positive, alpha-beta T cell	24 studies	27% ± 9%	Explore
T cell	18 studies	24% ± 7%	Explore
regulatory T cell	18 studies	32% ± 9%	Explore
CD16-positive, CD56-dim natural killer cell, human	14 studies	28% ± 11%	Explore
mature NK T cell	12 studies	27% ± 10%	Explore
gamma-delta T cell	12 studies	27% ± 9%	Explore
CD8-positive, alpha-beta memory T cell	11 studies	26% ± 11%	Explore
CD16-negative, CD56-bright natural killer cell, human	11 studies	26% ± 7%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	11 studies	23% ± 5%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	10 studies	27% ± 6%	Explore
mucosal invariant T cell	10 studies	24% ± 5%	Explore
CD4-positive, alpha-beta memory T cell	9 studies	27% ± 8%	Explore
B cell	9 studies	21% ± 5%	Explore
classical monocyte	6 studies	25% ± 6%	Explore
effector memory CD8-positive, alpha-beta T cell	6 studies	27% ± 7%	Explore
dendritic cell	6 studies	30% ± 13%	Explore
macrophage	6 studies	20% ± 3%	Explore
plasmacytoid dendritic cell	6 studies	22% ± 6%	Explore
exhausted T cell	5 studies	35% ± 8%	Explore
conventional dendritic cell	5 studies	32% ± 15%	Explore
T follicular helper cell	5 studies	24% ± 2%	Explore
memory B cell	5 studies	21% ± 4%	Explore
effector CD8-positive, alpha-beta T cell	5 studies	24% ± 8%	Explore
microglial cell	5 studies	25% ± 6%	Explore
plasma cell	4 studies	26% ± 10%	Explore
plasmablast	4 studies	41% ± 18%	Explore
lymphocyte	4 studies	23% ± 2%	Explore
naive B cell	4 studies	22% ± 5%	Explore
effector CD4-positive, alpha-beta T cell	4 studies	34% ± 9%	Explore
effector memory CD4-positive, alpha-beta T cell	4 studies	34% ± 4%	Explore
effector memory CD8-positive, alpha-beta T cell, terminally differentiated	4 studies	21% ± 4%	Explore
hematopoietic precursor cell	3 studies	23% ± 3%	Explore
non-classical monocyte	3 studies	21% ± 3%	Explore
immature B cell	3 studies	22% ± 6%	Explore
monocyte	3 studies	20% ± 4%	Explore
myeloid cell	3 studies	19% ± 3%	Explore
leukocyte	3 studies	18% ± 2%	Explore
group 3 innate lymphoid cell	3 studies	26% ± 10%	Explore
T-helper 17 cell	3 studies	18% ± 1%	Explore
T-helper 1 cell	3 studies	26% ± 4%	Explore
innate lymphoid cell	3 studies	26% ± 8%	Explore
double negative thymocyte	3 studies	28% ± 7%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
peripheral blood	11 studies	22% ± 3%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
lung	99%	1756.79	574 / 578	99%	36.25	1144 / 1155
pancreas	100%	1358.56	327 / 328	98%	37.02	175 / 178
prostate	96%	2586.73	234 / 245	100%	40.63	502 / 502
thymus	96%	1051.42	630 / 653	96%	39.59	578 / 605
stomach	80%	1088.87	287 / 359	97%	25.89	276 / 286
bladder	71%	1067.38	15 / 21	98%	40.84	496 / 504
breast	68%	634.82	311 / 459	98%	32.42	1101 / 1118
intestine	61%	1278.60	594 / 966	98%	29.50	515 / 527
skin	72%	2062.60	1307 / 1809	83%	23.99	394 / 472
esophagus	45%	1077.59	655 / 1445	99%	31.75	182 / 183
uterus	45%	260.01	77 / 170	97%	48.96	445 / 459
ovary	31%	163.65	55 / 180	94%	15.06	403 / 430
kidney	42%	390.92	37 / 89	79%	14.58	715 / 901
brain	32%	216.46	857 / 2642	79%	14.97	560 / 705
lymph node	0%	0	0 / 0	100%	129.95	29 / 29
peripheral blood	100%	8764.23	929 / 929	0%	0	0 / 0
spleen	100%	7177.97	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	67.06	45 / 45
ureter	0%	0	0 / 0	100%	24.91	1 / 1
adrenal gland	48%	263.87	123 / 258	33%	3.54	75 / 230
liver	28%	156.00	64 / 226	46%	7.47	185 / 406
adipose	71%	526.70	850 / 1204	0%	0	0 / 0
eye	0%	0	0 / 0	70%	10.89	56 / 80
blood vessel	24%	197.55	324 / 1335	0%	0	0 / 0
heart	8%	45.35	66 / 861	0%	0	0 / 0
muscle	0%	1.15	2 / 803	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0051056	Biological process	regulation of small GTPase mediated signal transduction
GO_0098876	Biological process	vesicle-mediated transport to the plasma membrane
GO_0030175	Cellular component	filopodium
GO_0005856	Cellular component	cytoskeleton
GO_0005654	Cellular component	nucleoplasm
GO_0005829	Cellular component	cytosol
GO_0005886	Cellular component	plasma membrane
GO_0048471	Cellular component	perinuclear region of cytoplasm
GO_0016020	Cellular component	membrane
GO_0005737	Cellular component	cytoplasm
GO_0005634	Cellular component	nucleus
GO_0005085	Molecular function	guanyl-nucleotide exchange factor activity
GO_0005515	Molecular function	protein binding

IV. Literature review

[source]

Gene name	DEF6
Protein name	Differentially expressed in FDCP 6 homolog (DEF-6) (IRF4-binding protein) Differentially expressed in FDCP 6 homolog (Mouse), isoform CRA_b (cDNA FLJ36294 fis, clone THYMU2004123, highly similar to Homo sapiens differentially expressed in FDCP 6 homolog (mouse) (DEF6), mRNA) DEF6 guanine nucleotide exchange factor
Synonyms	hCG_17662 IBP
Description	FUNCTION: Phosphatidylinositol 3,4,5-trisphosphate-dependent guanine nucleotide exchange factor (GEF) which plays a role in the activation of Rho GTPases RAC1, RhoA and CDC42 . Can regulate cell morphology in cooperation with activated RAC1 (By similarity). Involved in immune homeostasis by ensuring proper trafficking and availability of T-cell regulator CTLA-4 at T-cell surface . Plays a role in Th2 (T helper cells) development and/or activation, perhaps by interfering with ZAP70 signaling (By similarity). .
Accessions	H0Y7V7 A0A8V8TNX4 ENST00000316637.7 B3KSI1 Q9H4E7 ENST00000698930.1 ENST00000444278.3 A0A8V8TMY0 ENST00000698929.1

DEF6 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review