Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| oligodendrocyte | 12 studies | 32% ± 14% | |
| epithelial cell | 4 studies | 26% ± 7% | |
| pericyte | 4 studies | 17% ± 2% | |
| endothelial cell | 4 studies | 22% ± 4% | |
| CD16-positive, CD56-dim natural killer cell, human | 3 studies | 20% ± 4% | |
| natural killer cell | 3 studies | 16% ± 1% | |
| basal cell | 3 studies | 27% ± 8% | |
| smooth muscle cell | 3 studies | 19% ± 3% | |
| goblet cell | 3 studies | 20% ± 3% | |
| astrocyte | 3 studies | 17% ± 2% |
Insufficient scRNA-seq data for expression of PLEKHG3 at tissue level.
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| pancreas | 100% | 3266.57 | 328 / 328 | 100% | 18.94 | 178 / 178 |
| uterus | 100% | 8597.86 | 170 / 170 | 100% | 23.96 | 457 / 459 |
| ovary | 100% | 4964.79 | 180 / 180 | 100% | 16.84 | 428 / 430 |
| esophagus | 100% | 4491.63 | 1444 / 1445 | 99% | 24.38 | 182 / 183 |
| intestine | 100% | 4743.03 | 965 / 966 | 99% | 16.14 | 520 / 527 |
| breast | 100% | 3970.49 | 457 / 459 | 99% | 14.18 | 1103 / 1118 |
| kidney | 100% | 5539.55 | 89 / 89 | 98% | 14.80 | 880 / 901 |
| thymus | 100% | 4059.76 | 652 / 653 | 98% | 14.52 | 591 / 605 |
| bladder | 100% | 4623.62 | 21 / 21 | 96% | 16.07 | 486 / 504 |
| stomach | 100% | 2772.35 | 359 / 359 | 93% | 12.53 | 267 / 286 |
| liver | 100% | 2833.72 | 226 / 226 | 93% | 8.88 | 379 / 406 |
| lung | 99% | 2366.79 | 571 / 578 | 93% | 14.61 | 1078 / 1155 |
| brain | 98% | 3534.78 | 2593 / 2642 | 94% | 13.40 | 661 / 705 |
| prostate | 100% | 3907.53 | 245 / 245 | 92% | 7.36 | 461 / 502 |
| skin | 80% | 4728.32 | 1446 / 1809 | 93% | 16.15 | 438 / 472 |
| blood vessel | 100% | 9838.00 | 1335 / 1335 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 100% | 24.25 | 80 / 80 |
| spleen | 100% | 4361.73 | 241 / 241 | 0% | 0 | 0 / 0 |
| tonsil | 0% | 0 | 0 / 0 | 100% | 24.39 | 45 / 45 |
| ureter | 0% | 0 | 0 / 0 | 100% | 4.52 | 1 / 1 |
| adipose | 100% | 3996.33 | 1201 / 1204 | 0% | 0 | 0 / 0 |
| heart | 90% | 1786.81 | 772 / 861 | 0% | 0 | 0 / 0 |
| peripheral blood | 80% | 3981.30 | 743 / 929 | 0% | 0 | 0 / 0 |
| muscle | 57% | 742.21 | 456 / 803 | 0% | 0 | 0 / 0 |
| adrenal gland | 15% | 162.05 | 39 / 258 | 40% | 2.26 | 93 / 230 |
| lymph node | 0% | 0 | 0 / 0 | 52% | 4.13 | 15 / 29 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| GO_0051056 | Biological process | regulation of small GTPase mediated signal transduction |
| GO_2000114 | Biological process | regulation of establishment of cell polarity |
| GO_0030334 | Biological process | regulation of cell migration |
| GO_0005856 | Cellular component | cytoskeleton |
| GO_0005829 | Cellular component | cytosol |
| GO_0005085 | Molecular function | guanyl-nucleotide exchange factor activity |
| GO_0003779 | Molecular function | actin binding |
| GO_0031267 | Molecular function | small GTPase binding |
| Gene name | PLEKHG3 |
| Protein name | Pleckstrin homology and RhoGEF domain containing G3 PLEKHG3 Pleckstrin homology domain-containing family G member 3 (PH domain-containing family G member 3) |
| Synonyms | KIAA0599 |
| Description | FUNCTION: Plays a role in controlling cell polarity and cell motility by selectively binding newly polymerized actin and activating RAC1 and CDC42 to enhance local actin polymerization. . |
| Accessions | ENST00000634379.2 A1L390 ENST00000394691.7 [A1L390-3] ENST00000554499.1 ENST00000555982.5 G3V3I3 G3V278 A0A2X0SFH4 ENST00000484731.3 A0A0U1RR71 ENST00000471182.7 ENST00000247226.13 [A1L390-1] G3V311 A0A8C8NWT4 |
