Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| pericyte | 7 studies | 21% ± 9% | |
| cardiac muscle cell | 6 studies | 61% ± 23% | |
| GABAergic neuron | 3 studies | 27% ± 9% | |
| glutamatergic neuron | 3 studies | 24% ± 4% | |
| epithelial cell | 3 studies | 37% ± 14% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| thymus | 100% | 8301.04 | 651 / 653 | 99% | 5.36 | 599 / 605 |
| ovary | 97% | 5738.62 | 175 / 180 | 93% | 4.69 | 398 / 430 |
| kidney | 100% | 5296.26 | 89 / 89 | 82% | 3.08 | 738 / 901 |
| lung | 97% | 6898.10 | 560 / 578 | 74% | 2.38 | 854 / 1155 |
| esophagus | 90% | 4499.22 | 1295 / 1445 | 80% | 2.95 | 146 / 183 |
| prostate | 93% | 8756.57 | 228 / 245 | 69% | 2.00 | 347 / 502 |
| uterus | 81% | 3938.25 | 138 / 170 | 76% | 3.04 | 351 / 459 |
| pancreas | 70% | 2043.82 | 228 / 328 | 74% | 1.63 | 131 / 178 |
| intestine | 89% | 3555.37 | 858 / 966 | 49% | 1.15 | 259 / 527 |
| breast | 56% | 3181.82 | 259 / 459 | 73% | 2.22 | 817 / 1118 |
| bladder | 62% | 2312.90 | 13 / 21 | 56% | 1.53 | 284 / 504 |
| stomach | 62% | 2942.12 | 224 / 359 | 51% | 1.33 | 145 / 286 |
| skin | 55% | 2103.85 | 1001 / 1809 | 51% | 1.49 | 243 / 472 |
| muscle | 100% | 218160.28 | 803 / 803 | 0% | 0 | 0 / 0 |
| spleen | 100% | 6437.30 | 241 / 241 | 0% | 0 | 0 / 0 |
| ureter | 0% | 0 | 0 / 0 | 100% | 1.19 | 1 / 1 |
| heart | 99% | 34009.46 | 856 / 861 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 99% | 5.61 | 79 / 80 |
| brain | 60% | 4845.73 | 1582 / 2642 | 18% | 0.35 | 126 / 705 |
| tonsil | 0% | 0 | 0 / 0 | 71% | 2.10 | 32 / 45 |
| adrenal gland | 34% | 837.43 | 88 / 258 | 34% | 1.33 | 78 / 230 |
| adipose | 32% | 1079.78 | 380 / 1204 | 0% | 0 | 0 / 0 |
| lymph node | 0% | 0 | 0 / 0 | 31% | 0.53 | 9 / 29 |
| liver | 1% | 23.62 | 2 / 226 | 22% | 0.96 | 91 / 406 |
| peripheral blood | 6% | 204.06 | 58 / 929 | 0% | 0 | 0 / 0 |
| blood vessel | 6% | 267.18 | 76 / 1335 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| GO_0051056 | Biological process | regulation of small GTPase mediated signal transduction |
| GO_0036309 | Biological process | protein localization to M-band |
| GO_0045214 | Biological process | sarcomere organization |
| GO_0005886 | Cellular component | plasma membrane |
| GO_0030018 | Cellular component | Z disc |
| GO_0030016 | Cellular component | myofibril |
| GO_0042383 | Cellular component | sarcolemma |
| GO_0016604 | Cellular component | nuclear body |
| GO_0005829 | Cellular component | cytosol |
| GO_0031430 | Cellular component | M band |
| GO_0005085 | Molecular function | guanyl-nucleotide exchange factor activity |
| GO_0005547 | Molecular function | phosphatidylinositol-3,4,5-trisphosphate binding |
| GO_0106310 | Molecular function | protein serine kinase activity |
| GO_0008307 | Molecular function | structural constituent of muscle |
| GO_0070273 | Molecular function | phosphatidylinositol-4-phosphate binding |
| GO_0031432 | Molecular function | titin binding |
| GO_0005546 | Molecular function | phosphatidylinositol-4,5-bisphosphate binding |
| GO_0004674 | Molecular function | protein serine/threonine kinase activity |
| GO_0032266 | Molecular function | phosphatidylinositol-3-phosphate binding |
| GO_0046872 | Molecular function | metal ion binding |
| GO_0005524 | Molecular function | ATP binding |
| GO_0030506 | Molecular function | ankyrin binding |
| GO_0005516 | Molecular function | calmodulin binding |
| GO_0005515 | Molecular function | protein binding |
| GO_0010314 | Molecular function | phosphatidylinositol-5-phosphate binding |
| GO_0043325 | Molecular function | phosphatidylinositol-3,4-bisphosphate binding |
| Gene name | OBSCN |
| Protein name | OBSCN protein Obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF Obscurin (EC 2.7.11.1) (Obscurin-RhoGEF) (Obscurin-myosin light chain kinase) (Obscurin-MLCK) Obscurin isoform B |
| Synonyms | KIAA1639 KIAA1556 |
| Description | FUNCTION: Structural component of striated muscles which plays a role in myofibrillogenesis. Probably involved in the assembly of myosin into sarcomeric A bands in striated muscle . Has serine/threonine protein kinase activity and phosphorylates N-cadherin CDH2 and sodium/potassium-transporting ATPase subunit ATP1B1 (By similarity). Binds (via the PH domain) strongly to phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4)P2) and phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2), and to a lesser extent to phosphatidylinositol 3-phosphate (PtdIns(3)P), phosphatidylinositol 4-phosphate (PtdIns(4)P), phosphatidylinositol 5-phosphate (PtdIns(5)P) and phosphatidylinositol 3,4,5-trisphosphate (PtdIns(3,4,5)P3) . . |
| Accessions | A0A590UJV7 A9NIU4 Q4KMX9 ENST00000668629.1 A0A590UJ33 A0A0A0MRI8 ENST00000668943.1 H3BPW6 ENST00000664353.1 ENST00000493977.2 ENST00000660857.1 ENST00000422127.5 [Q5VST9-1] ENST00000474237.2 ENST00000483539.3 A0A590UJH9 A0A590UJD5 ENST00000664957.1 Q5VST9 ENST00000665495.1 ENST00000366704.2 A0A7P0Z489 A0A590UJ10 A6NGQ3 ENST00000366706.7 A0A590UJD0 ENST00000284548.16 [Q5VST9-3] Q24JT4 ENST00000668066.1 H3BQA7 ENST00000680850.1 A0A590UK18 ENST00000570156.7 ENST00000636476.2 [Q5VST9-2] ENST00000662438.1 [Q5VST9-6] ENST00000664561.1 A0A590UKA5 A0A590UJ65 A0A590UJJ2 |
