ARHGEF4 | OmnibusX

Name	Number of supported studies	Average coverage
astrocyte	16 studies	53% ± 22%	Explore
oligodendrocyte precursor cell	12 studies	44% ± 18%	Explore
glutamatergic neuron	9 studies	39% ± 25%	Explore
GABAergic neuron	7 studies	41% ± 23%	Explore
interneuron	4 studies	41% ± 15%	Explore
neuron	3 studies	28% ± 10%	Explore
GABAergic interneuron	3 studies	19% ± 2%	Explore
GABAergic amacrine cell	3 studies	21% ± 2%	Explore
retinal cone cell	3 studies	22% ± 4%	Explore
ependymal cell	3 studies	37% ± 19%	Explore
oligodendrocyte	3 studies	26% ± 13%	Explore

Name	Number of supported studies	Average coverage
brain	12 studies	32% ± 18%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
brain	100%	12697.31	2635 / 2642	99%	50.13	700 / 705
thymus	93%	2535.14	610 / 653	74%	5.62	447 / 605
esophagus	87%	4290.40	1258 / 1445	79%	27.57	144 / 183
pancreas	97%	2699.32	318 / 328	57%	3.68	101 / 178
prostate	73%	1709.98	180 / 245	69%	3.65	344 / 502
ovary	79%	1851.53	143 / 180	50%	3.10	213 / 430
uterus	27%	550.13	46 / 170	78%	15.36	360 / 459
tonsil	0%	0	0 / 0	93%	19.82	42 / 45
skin	72%	7832.26	1299 / 1809	18%	1.45	84 / 472
bladder	38%	941.19	8 / 21	37%	4.53	187 / 504
intestine	49%	1123.55	474 / 966	20%	1.81	107 / 527
lung	13%	204.61	74 / 578	55%	8.59	639 / 1155
eye	0%	0	0 / 0	65%	3.76	52 / 80
adrenal gland	5%	108.95	14 / 258	60%	9.96	137 / 230
stomach	23%	567.94	83 / 359	18%	1.07	52 / 286
breast	15%	266.17	70 / 459	18%	1.13	205 / 1118
adipose	18%	342.56	219 / 1204	0%	0	0 / 0
lymph node	0%	0	0 / 0	7%	0.42	2 / 29
liver	0%	6.09	1 / 226	3%	0.22	13 / 406
muscle	3%	49.57	27 / 803	0%	0	0 / 0
blood vessel	3%	51.47	40 / 1335	0%	0	0 / 0
kidney	0%	0	0 / 89	2%	0.18	19 / 901
heart	0%	1.53	1 / 861	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
peripheral blood	0%	0	0 / 929	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
spleen	0%	0	0 / 241	0%	0	0 / 0
ureter	0%	0	0 / 0	0%	0	0 / 1

GO_0046847	Biological process	filopodium assembly
GO_0051056	Biological process	regulation of small GTPase mediated signal transduction
GO_0035556	Biological process	intracellular signal transduction
GO_0030032	Biological process	lamellipodium assembly
GO_0032587	Cellular component	ruffle membrane
GO_0005829	Cellular component	cytosol
GO_0005085	Molecular function	guanyl-nucleotide exchange factor activity
GO_0019904	Molecular function	protein domain specific binding
GO_0005515	Molecular function	protein binding

Gene name	ARHGEF4
Protein name	Uncharacterized protein ARHGEF4 Rho guanine nucleotide exchange factor 4 (APC-stimulated guanine nucleotide exchange factor 1) (Asef) (Asef1) Rho guanine nucleotide exchange factor 4 ARHGEF4 protein (Rho guanine nucleotide exchange factor 4) ARHGEF4
Synonyms	KIAA1112
Description	FUNCTION: Acts as a guanine nucleotide exchange factor (GEF) for RHOA, RAC1 and CDC42 GTPases. Binding of APC may activate RAC1 GEF activity. The APC-ARHGEF4 complex seems to be involved in cell migration as well as in E-cadherin-mediated cell-cell adhesion. Required for MMP9 up-regulation via the JNK signaling pathway in colorectal tumor cells. Involved in tumor angiogenesis and may play a role in intestinal adenoma formation and tumor progression. .
Accessions	A0A2X0SFW4 ENST00000611048.4 ENST00000355771.7 [Q9NR80-3] ENST00000636987.1 ENST00000532720.1 ENST00000392953.8 Q9NR80 A0A087X0P1 Q53TH6 E7EV07 ENST00000409359.7 A4QPB6 ENST00000428230.6 ENST00000438985.5 A0A1B0GW00 A0A0C4DFY6 ENST00000326016.10 [Q9NR80-1] ENST00000409303.6 H0YCT6 H0Y451 E9PEM0 Q53QF2

ARHGEF4 report