RCC2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0034260Biological processnegative regulation of GTPase activity
GO_0010971Biological processpositive regulation of G2/M transition of mitotic cell cycle
GO_0045184Biological processestablishment of protein localization
GO_0051895Biological processnegative regulation of focal adhesion assembly
GO_0051301Biological processcell division
GO_0051987Biological processpositive regulation of attachment of spindle microtubules to kinetochore
GO_0072356Biological processchromosome passenger complex localization to kinetochore
GO_0007229Biological processintegrin-mediated signaling pathway
GO_0030334Biological processregulation of cell migration
GO_0048041Biological processfocal adhesion assembly
GO_1900025Biological processnegative regulation of substrate adhesion-dependent cell spreading
GO_0010762Biological processregulation of fibroblast migration
GO_1900027Biological processregulation of ruffle assembly
GO_0005730Cellular componentnucleolus
GO_0030496Cellular componentmidbody
GO_0005886Cellular componentplasma membrane
GO_0005874Cellular componentmicrotubule
GO_0016020Cellular componentmembrane
GO_0031901Cellular componentearly endosome membrane
GO_1990023Cellular componentmitotic spindle midzone
GO_0034506Cellular componentchromosome, centromeric core domain
GO_0005829Cellular componentcytosol
GO_0005085Molecular functionguanyl-nucleotide exchange factor activity
GO_0019904Molecular functionprotein domain specific binding
GO_0019901Molecular functionprotein kinase binding
GO_0031267Molecular functionsmall GTPase binding
GO_0008017Molecular functionmicrotubule binding
GO_0003723Molecular functionRNA binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameRCC2
Protein nameProtein RCC2 (RCC1-like protein TD-60) (Telophase disk protein of 60 kDa)
RCC2 protein
Epididymis secretory sperm binding protein (Regulator of chromosome condensation 2, isoform CRA_a)
SynonymsKIAA1470
TD60
hCG_25129
DescriptionFUNCTION: Multifunctional protein that may affect its functions by regulating the activity of small GTPases, such as RAC1 and RALA . Required for normal progress through the cell cycle, both during interphase and during mitosis . Required for the presence of normal levels of MAD2L1, AURKB and BIRC5 on inner centromeres during mitosis, and for normal attachment of kinetochores to mitotic spindles . Required for normal organization of the microtubule cytoskeleton in interphase cells . Functions as guanine nucleotide exchange factor (GEF) for RALA . Interferes with the activation of RAC1 by guanine nucleotide exchange factors . Prevents accumulation of active, GTP-bound RAC1, and suppresses RAC1-mediated reorganization of the actin cytoskeleton and formation of membrane protrusions . Required for normal cellular responses to contacts with the extracellular matrix of adjacent cells, and for directional cell migration in response to a fibronectin gradient (in vitro) . .

AccessionsENST00000375433.3
A0A024RAC5
ENST00000375436.9
A5PLK7
ENST00000628984.1
Q9P258
ENST00000631021.3