RCC1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0007059Biological processchromosome segregation
GO_0007052Biological processmitotic spindle organization
GO_0051301Biological processcell division
GO_0051225Biological processspindle assembly
GO_0007084Biological processmitotic nuclear membrane reassembly
GO_0016032Biological processviral process
GO_0000082Biological processG1/S transition of mitotic cell cycle
GO_0007088Biological processregulation of mitotic nuclear division
GO_0032991Cellular componentprotein-containing complex
GO_0005654Cellular componentnucleoplasm
GO_0005737Cellular componentcytoplasm
GO_0005694Cellular componentchromosome
GO_0000794Cellular componentcondensed nuclear chromosome
GO_0000785Cellular componentchromatin
GO_0005634Cellular componentnucleus
GO_0005085Molecular functionguanyl-nucleotide exchange factor activity
GO_0042393Molecular functionhistone binding
GO_0003682Molecular functionchromatin binding
GO_0031492Molecular functionnucleosomal DNA binding
GO_0043199Molecular functionsulfate binding
GO_0031267Molecular functionsmall GTPase binding
GO_0031491Molecular functionnucleosome binding
GO_0046982Molecular functionprotein heterodimerization activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameRCC1
Protein nameRegulator of chromosome condensation (Cell cycle regulatory protein) (Chromosome condensation protein 1)
Regulator of chromosome condensation
Regulator of chromosome condensation 1
SynonymshCG_27809
CHC1
DescriptionFUNCTION: Guanine-nucleotide releasing factor that promotes the exchange of Ran-bound GDP by GTP, and thereby plays an important role in RAN-mediated functions in nuclear import and mitosis . Contributes to the generation of high levels of chromosome-associated, GTP-bound RAN, which is important for mitotic spindle assembly and normal progress through mitosis . Via its role in maintaining high levels of GTP-bound RAN in the nucleus, contributes to the release of cargo proteins from importins after nuclear import . Involved in the regulation of onset of chromosome condensation in the S phase . Binds both to the nucleosomes and double-stranded DNA . .

AccessionsENST00000373831.7 [P18754-2]
ENST00000434290.6
ENST00000373833.10 [P18754-1]
Q5T081
P18754
ENST00000683442.1 [P18754-1]
ENST00000430407.1
C9JRH2
ENST00000419074.5
ENST00000649185.1 [P18754-2]
A0A0S2Z404
ENST00000427469.5
M0R1Q8
ENST00000398958.6 [P18754-1]
C9JQZ4
ENST00000373832.5 [P18754-1]
A0A0S2Z3I4
ENST00000486790.2
C9JW69
ENST00000411533.5
C9JMJ4
C9J3R0