Name | Number of supported studies | Average coverage | |
---|---|---|---|
astrocyte | 18 studies | 49% ± 20% | |
oligodendrocyte | 15 studies | 64% ± 19% | |
oligodendrocyte precursor cell | 14 studies | 62% ± 20% | |
glutamatergic neuron | 12 studies | 81% ± 20% | |
GABAergic neuron | 10 studies | 75% ± 20% | |
microglial cell | 8 studies | 34% ± 18% | |
interneuron | 6 studies | 79% ± 19% | |
smooth muscle cell | 6 studies | 23% ± 8% | |
endothelial cell | 5 studies | 51% ± 21% | |
cardiac muscle cell | 5 studies | 47% ± 13% | |
neuron | 4 studies | 61% ± 14% | |
epithelial cell | 4 studies | 56% ± 21% | |
granule cell | 4 studies | 73% ± 15% | |
Mueller cell | 4 studies | 31% ± 11% | |
amacrine cell | 4 studies | 74% ± 13% | |
retina horizontal cell | 4 studies | 77% ± 9% | |
retinal cone cell | 4 studies | 32% ± 10% | |
retinal ganglion cell | 4 studies | 81% ± 10% | |
differentiation-committed oligodendrocyte precursor | 3 studies | 55% ± 5% | |
GABAergic interneuron | 3 studies | 85% ± 13% | |
GABAergic amacrine cell | 3 studies | 78% ± 8% | |
OFF-bipolar cell | 3 studies | 62% ± 9% | |
ON-bipolar cell | 3 studies | 64% ± 9% | |
glycinergic amacrine cell | 3 studies | 71% ± 4% | |
retinal rod cell | 3 studies | 24% ± 2% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
brain | 99% | 6296.15 | 2626 / 2642 | 97% | 21.01 | 683 / 705 |
thymus | 100% | 6065.43 | 652 / 653 | 86% | 22.36 | 521 / 605 |
adrenal gland | 92% | 1404.30 | 237 / 258 | 86% | 9.83 | 198 / 230 |
esophagus | 86% | 1907.64 | 1242 / 1445 | 28% | 1.13 | 52 / 183 |
ureter | 0% | 0 | 0 / 0 | 100% | 3.27 | 1 / 1 |
bladder | 62% | 795.43 | 13 / 21 | 36% | 2.28 | 180 / 504 |
prostate | 70% | 850.42 | 171 / 245 | 15% | 0.56 | 75 / 502 |
heart | 78% | 823.55 | 673 / 861 | 0% | 0 | 0 / 0 |
skin | 57% | 593.68 | 1023 / 1809 | 8% | 0.44 | 37 / 472 |
intestine | 60% | 824.20 | 575 / 966 | 4% | 0.18 | 21 / 527 |
blood vessel | 46% | 517.08 | 620 / 1335 | 0% | 0 | 0 / 0 |
stomach | 32% | 486.53 | 114 / 359 | 8% | 0.37 | 22 / 286 |
ovary | 5% | 46.40 | 9 / 180 | 34% | 1.52 | 146 / 430 |
uterus | 19% | 164.96 | 33 / 170 | 19% | 1.34 | 86 / 459 |
muscle | 34% | 305.90 | 271 / 803 | 0% | 0 | 0 / 0 |
lung | 6% | 52.36 | 36 / 578 | 25% | 1.11 | 283 / 1155 |
breast | 3% | 39.54 | 16 / 459 | 18% | 0.99 | 203 / 1118 |
kidney | 7% | 46.31 | 6 / 89 | 14% | 0.69 | 122 / 901 |
adipose | 18% | 167.71 | 217 / 1204 | 0% | 0 | 0 / 0 |
pancreas | 1% | 3.92 | 2 / 328 | 17% | 0.86 | 30 / 178 |
tonsil | 0% | 0 | 0 / 0 | 7% | 0.27 | 3 / 45 |
spleen | 4% | 27.50 | 10 / 241 | 0% | 0 | 0 / 0 |
eye | 0% | 0 | 0 / 0 | 4% | 0.18 | 3 / 80 |
lymph node | 0% | 0 | 0 / 0 | 3% | 0.14 | 1 / 29 |
liver | 0% | 0 | 0 / 226 | 1% | 0.06 | 6 / 406 |
peripheral blood | 0% | 1.87 | 3 / 929 | 0% | 0 | 0 / 0 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
GO_0051056 | Biological process | regulation of small GTPase mediated signal transduction |
GO_0007264 | Biological process | small GTPase-mediated signal transduction |
GO_0048011 | Biological process | neurotrophin TRK receptor signaling pathway |
GO_0005829 | Cellular component | cytosol |
GO_0005886 | Cellular component | plasma membrane |
GO_0005737 | Cellular component | cytoplasm |
GO_0005085 | Molecular function | guanyl-nucleotide exchange factor activity |
GO_0005515 | Molecular function | protein binding |
GO_0031267 | Molecular function | small GTPase binding |
GO_0005096 | Molecular function | GTPase activator activity |
GO_0017124 | Molecular function | SH3 domain binding |
Gene name | DOCK3 |
Protein name | DOCK3 DOCK3 protein Dedicator of cytokinesis protein 3 (Modifier of cell adhesion) (Presenilin-binding protein) (PBP) Alternative protein DOCK3 |
Synonyms | KIAA0299 MOCA |
Description | FUNCTION: Potential guanine nucleotide exchange factor (GEF). GEF proteins activate some small GTPases by exchanging bound GDP for free GTP. Its interaction with presenilin proteins as well as its ability to stimulate Tau/MAPT phosphorylation suggest that it may be involved in Alzheimer disease. Ectopic expression in nerve cells decreases the secretion of amyloid-beta APBA1 protein and lowers the rate of cell-substratum adhesion, suggesting that it may affect the function of some small GTPase involved in the regulation of actin cytoskeleton or cell adhesion receptors (By similarity). . |
Accessions | A0A2X0SFH6 L8E7Q6 Q8IZD9 A3KMG4 ENST00000266037.10 |