PREB report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of PREB at tissue level.

III. Associated gene sets

GO_0042953Biological processlipoprotein transport
GO_0006888Biological processendoplasmic reticulum to Golgi vesicle-mediated transport
GO_0048208Biological processCOPII vesicle coating
GO_0003400Biological processregulation of COPII vesicle coating
GO_0070971Cellular componentendoplasmic reticulum exit site
GO_0016020Cellular componentmembrane
GO_0005789Cellular componentendoplasmic reticulum membrane
GO_0005634Cellular componentnucleus
GO_0003677Molecular functionDNA binding
GO_0005085Molecular functionguanyl-nucleotide exchange factor activity
GO_0051020Molecular functionGTPase binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene namePREB
Protein nameProlactin regulatory element binding
Prolactin regulatory element-binding protein (Mammalian guanine nucleotide exchange factor mSec12)
Prometheus B
SynonymshCG_23709
SEC12
DescriptionFUNCTION: Guanine nucleotide exchange factor that specifically activates the small GTPase SAR1B. Mediates the recruitment of SAR1B and other COPII coat components to endoplasmic reticulum membranes and is therefore required for the formation of COPII transport vesicles from the ER. .; FUNCTION: Was first identified based on its probable role in the regulation of pituitary gene transcription. Binds to the prolactin gene (PRL) promoter and seems to activate transcription. .

FUNCTION: Guanine nucleotide exchange factor that specifically activates the small GTPase SAR1B. Mediates the recruitment of SAR1B and other COPII coat components to endoplasmic reticulum membranes and is therefore required for the formation of COPII transport vesicles from the ER. .; FUNCTION: Was first identified based on its probable role in the regulation of pituitary gene transcription. Binds to the prolactin gene (PRL) promoter and seems to activate transcription. .

FUNCTION: Guanine nucleotide exchange factor that specifically activates the small GTPase SAR1B. Mediates the recruitment of SAR1B and other COPII coat components to endoplasmic reticulum membranes and is therefore required for the formation of COPII transport vesicles from the ER. .; FUNCTION: Was first identified based on its probable role in the regulation of pituitary gene transcription. Binds to the prolactin gene (PRL) promoter and seems to activate transcription. .

FUNCTION: Guanine nucleotide exchange factor that specifically activates the small GTPase SAR1B. Mediates the recruitment of SAR1B and other COPII coat components to endoplasmic reticulum membranes and is therefore required for the formation of COPII transport vesicles from the ER. .; FUNCTION: Was first identified based on its probable role in the regulation of pituitary gene transcription. Binds to the prolactin gene (PRL) promoter and seems to activate transcription. .

FUNCTION: Guanine nucleotide exchange factor that specifically activates the small GTPase SAR1B. Mediates the recruitment of SAR1B and other COPII coat components to endoplasmic reticulum membranes and is therefore required for the formation of COPII transport vesicles from the ER. .; FUNCTION: Was first identified based on its probable role in the regulation of pituitary gene transcription. Binds to the prolactin gene (PRL) promoter and seems to activate transcription. .

AccessionsQ05DB2
B5MC98
A0A0F7RPZ8
ENST00000430533.1
H7C2N7
F8WCS5
H7BZX0
ENST00000456259.5
ENST00000444452.5
ENST00000260643.7
H7C0W3
ENST00000441451.1
ENST00000406567.7
Q9HCU5