ITSN2 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
B cell	39 studies	35% ± 11%	Explore
endothelial cell	37 studies	34% ± 13%	Explore
macrophage	31 studies	33% ± 17%	Explore
natural killer cell	31 studies	24% ± 6%	Explore
T cell	22 studies	25% ± 8%	Explore
CD4-positive, alpha-beta T cell	22 studies	22% ± 5%	Explore
CD8-positive, alpha-beta T cell	22 studies	24% ± 5%	Explore
memory B cell	20 studies	37% ± 8%	Explore
naive B cell	20 studies	32% ± 9%	Explore
non-classical monocyte	19 studies	32% ± 13%	Explore
mast cell	17 studies	26% ± 7%	Explore
conventional dendritic cell	17 studies	29% ± 14%	Explore
classical monocyte	17 studies	25% ± 10%	Explore
regulatory T cell	17 studies	26% ± 6%	Explore
gamma-delta T cell	15 studies	25% ± 6%	Explore
microglial cell	15 studies	42% ± 16%	Explore
dendritic cell	14 studies	38% ± 18%	Explore
monocyte	14 studies	31% ± 15%	Explore
CD16-positive, CD56-dim natural killer cell, human	14 studies	27% ± 6%	Explore
CD16-negative, CD56-bright natural killer cell, human	14 studies	26% ± 7%	Explore
capillary endothelial cell	14 studies	23% ± 7%	Explore
oligodendrocyte	14 studies	35% ± 15%	Explore
mature NK T cell	13 studies	23% ± 5%	Explore
endothelial cell of artery	13 studies	34% ± 12%	Explore
astrocyte	13 studies	32% ± 17%	Explore
endothelial cell of lymphatic vessel	12 studies	29% ± 12%	Explore
CD8-positive, alpha-beta memory T cell	12 studies	26% ± 7%	Explore
fibroblast	12 studies	29% ± 11%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	11 studies	22% ± 6%	Explore
mucosal invariant T cell	11 studies	26% ± 7%	Explore
myeloid cell	11 studies	32% ± 11%	Explore
CD4-positive, alpha-beta memory T cell	10 studies	23% ± 5%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	10 studies	23% ± 4%	Explore
glutamatergic neuron	10 studies	44% ± 26%	Explore
oligodendrocyte precursor cell	10 studies	36% ± 16%	Explore
type I pneumocyte	9 studies	33% ± 9%	Explore
plasmacytoid dendritic cell	9 studies	26% ± 9%	Explore
GABAergic neuron	9 studies	40% ± 22%	Explore
effector memory CD8-positive, alpha-beta T cell	9 studies	27% ± 5%	Explore
type II pneumocyte	8 studies	40% ± 14%	Explore
epithelial cell	8 studies	38% ± 21%	Explore
adipocyte	8 studies	34% ± 10%	Explore
ciliated cell	8 studies	24% ± 9%	Explore
leukocyte	7 studies	28% ± 12%	Explore
basal cell	7 studies	25% ± 14%	Explore
smooth muscle cell	7 studies	26% ± 6%	Explore
precursor B cell	6 studies	32% ± 7%	Explore
vein endothelial cell	6 studies	23% ± 5%	Explore
T follicular helper cell	6 studies	22% ± 3%	Explore
endothelial cell of vascular tree	6 studies	30% ± 16%	Explore
plasmablast	5 studies	31% ± 14%	Explore
neuron	5 studies	40% ± 22%	Explore
pericyte	5 studies	28% ± 7%	Explore
pro-B cell	5 studies	28% ± 8%	Explore
retinal cone cell	5 studies	20% ± 4%	Explore
cardiac muscle cell	5 studies	28% ± 4%	Explore
mononuclear phagocyte	5 studies	34% ± 14%	Explore
lymphocyte	5 studies	34% ± 13%	Explore
club cell	5 studies	31% ± 8%	Explore
squamous epithelial cell	4 studies	38% ± 20%	Explore
exhausted T cell	4 studies	28% ± 9%	Explore
plasma cell	4 studies	30% ± 8%	Explore
immature B cell	4 studies	35% ± 6%	Explore
retinal pigment epithelial cell	4 studies	31% ± 24%	Explore
retinal rod cell	4 studies	21% ± 2%	Explore
secretory cell	4 studies	20% ± 4%	Explore
effector CD8-positive, alpha-beta T cell	4 studies	20% ± 5%	Explore
effector memory CD4-positive, alpha-beta T cell	4 studies	25% ± 6%	Explore
innate lymphoid cell	4 studies	26% ± 2%	Explore
alveolar macrophage	4 studies	40% ± 16%	Explore
effector memory CD8-positive, alpha-beta T cell, terminally differentiated	4 studies	25% ± 6%	Explore
interneuron	4 studies	56% ± 26%	Explore
abnormal cell	4 studies	32% ± 10%	Explore
hematopoietic precursor cell	3 studies	30% ± 11%	Explore
GABAergic interneuron	3 studies	28% ± 2%	Explore
glial cell	3 studies	19% ± 3%	Explore
megakaryocyte	3 studies	22% ± 5%	Explore
mesothelial cell	3 studies	25% ± 6%	Explore
tissue-resident macrophage	3 studies	29% ± 14%	Explore
Mueller cell	3 studies	24% ± 8%	Explore
respiratory goblet cell	3 studies	21% ± 5%	Explore
germinal center B cell	3 studies	44% ± 9%	Explore
hepatocyte	3 studies	41% ± 23%	Explore
muscle cell	3 studies	28% ± 14%	Explore
ependymal cell	3 studies	35% ± 17%	Explore
granulocyte	3 studies	23% ± 8%	Explore
hematopoietic stem cell	3 studies	20% ± 3%	Explore
adventitial cell	3 studies	21% ± 6%	Explore
group 3 innate lymphoid cell	3 studies	32% ± 10%	Explore
goblet cell	3 studies	37% ± 23%	Explore
granule cell	3 studies	19% ± 3%	Explore
mural cell	3 studies	42% ± 14%	Explore
mucus secreting cell	3 studies	24% ± 5%	Explore
enteroendocrine cell	3 studies	20% ± 3%	Explore
erythrocyte	3 studies	18% ± 2%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
brain	17 studies	36% ± 21%	Explore
peripheral blood	14 studies	26% ± 8%	Explore
lung	11 studies	27% ± 10%	Explore
eye	5 studies	28% ± 18%	Explore
liver	5 studies	25% ± 11%	Explore
bone marrow	4 studies	22% ± 4%	Explore
heart	4 studies	29% ± 2%	Explore
kidney	4 studies	24% ± 2%	Explore
lymph node	4 studies	25% ± 2%	Explore
adipose	4 studies	28% ± 8%	Explore
intestine	3 studies	18% ± 1%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
esophagus	100%	5561.92	1445 / 1445	100%	23.19	183 / 183
lung	100%	6935.30	578 / 578	100%	17.23	1153 / 1155
thymus	100%	10092.43	653 / 653	100%	32.81	603 / 605
bladder	100%	4361.71	21 / 21	100%	16.60	502 / 504
pancreas	100%	4003.94	328 / 328	99%	15.03	177 / 178
breast	100%	4002.57	459 / 459	99%	14.64	1107 / 1118
prostate	100%	4161.03	245 / 245	99%	12.43	497 / 502
kidney	100%	3521.56	89 / 89	99%	15.85	888 / 901
stomach	100%	3678.22	359 / 359	98%	14.03	281 / 286
intestine	100%	4826.09	966 / 966	98%	12.03	515 / 527
uterus	100%	4221.71	170 / 170	98%	15.32	448 / 459
ovary	100%	3836.64	180 / 180	97%	8.74	417 / 430
brain	97%	1936.86	2551 / 2642	98%	7.77	693 / 705
adrenal gland	100%	4716.09	258 / 258	95%	9.81	218 / 230
liver	100%	2411.13	226 / 226	93%	8.55	378 / 406
skin	100%	4736.31	1808 / 1809	92%	11.87	434 / 472
adipose	100%	4551.06	1204 / 1204	0%	0	0 / 0
blood vessel	100%	4806.52	1335 / 1335	0%	0	0 / 0
lymph node	0%	0	0 / 0	100%	24.02	29 / 29
spleen	100%	7237.06	241 / 241	0%	0	0 / 0
ureter	0%	0	0 / 0	100%	9.00	1 / 1
muscle	100%	3154.84	800 / 803	0%	0	0 / 0
heart	100%	2874.79	857 / 861	0%	0	0 / 0
tonsil	0%	0	0 / 0	98%	16.69	44 / 45
peripheral blood	97%	5116.91	900 / 929	0%	0	0 / 0
eye	0%	0	0 / 0	60%	4.20	48 / 80
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0016197	Biological process	endosomal transport
GO_1903861	Biological process	positive regulation of dendrite extension
GO_0030154	Biological process	cell differentiation
GO_0150007	Biological process	clathrin-dependent synaptic vesicle endocytosis
GO_0005813	Cellular component	centrosome
GO_0070062	Cellular component	extracellular exosome
GO_0005829	Cellular component	cytosol
GO_0005886	Cellular component	plasma membrane
GO_0097708	Cellular component	intracellular vesicle
GO_0042734	Cellular component	presynaptic membrane
GO_0005737	Cellular component	cytoplasm
GO_0005085	Molecular function	guanyl-nucleotide exchange factor activity
GO_0005509	Molecular function	calcium ion binding
GO_0005515	Molecular function	protein binding
GO_0060090	Molecular function	molecular adaptor activity

IV. Literature review

[source]

Gene name	ITSN2
Protein name	Intersectin 2 ITSN2 Uncharacterized protein ITSN2 Intersectin-2 (SH3 domain-containing protein 1B) (SH3P18) (SH3P18-like WASP-associated protein)
Synonyms	SWAP KIAA1256 SH3D1B
Description	FUNCTION: Adapter protein that may provide indirect link between the endocytic membrane traffic and the actin assembly machinery. May regulate the formation of clathrin-coated vesicles (CCPs). Seems to be involved in CCPs maturation including invagination or budding. Involved in endocytosis of integrin beta-1 (ITGB1) and transferrin receptor (TFR). Plays a role in dendrite formation by melanocytes . .
Accessions	H7BZD4 Q53TM3 H7C0L8 A0A2X0SSM1 H7C3E2 Q53TK4 ENST00000427234.5 A6H8W8 ENST00000361999.7 [Q9NZM3-2] ENST00000449392.1 F8W719 ENST00000443927.5 ENST00000355123.9 [Q9NZM3-1] ENST00000412011.5 ENST00000416160.1 ENST00000406921.7 [Q9NZM3-3] Q9NZM3 E7EPJ2

ITSN2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review