RCC1L report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0070131Biological processpositive regulation of mitochondrial translation
GO_0008053Biological processmitochondrial fusion
GO_0031966Cellular componentmitochondrial membrane
GO_0005743Cellular componentmitochondrial inner membrane
GO_0005525Molecular functionGTP binding
GO_0005085Molecular functionguanyl-nucleotide exchange factor activity
GO_0019843Molecular functionrRNA binding
GO_0005515Molecular functionprotein binding
GO_0003723Molecular functionRNA binding

IV. Literature review

[source]
Gene nameRCC1L
Protein nameRCC1-like G exchanging factor-like protein (RCC1-like) (Williams-Beuren syndrome chromosomal region 16 protein)
RCC1 like
SynonymsWBSCR16
DescriptionFUNCTION: Guanine nucleotide exchange factor (GEF) for mitochondrial dynamin-related GTPase OPA1. Activates OPA1, by exchanging bound GDP for free GTP, and drives OPA1 and MFN1-dependent mitochondrial fusion . Plays an essential role in mitochondrial ribosome biogenesis. As a component of a functional protein-RNA module, consisting of RCC1L, NGRN, RPUSD3, RPUSD4, TRUB2, FASTKD2 and 16S mitochondrial ribosomal RNA (16S mt-rRNA), controls 16S mt-rRNA abundance and is required for intra-mitochondrial translation of core subunits of the oxidative phosphorylation system . .

AccessionsENST00000614461.4 [Q96I51-3]
Q96I51
A0A087WT38
ENST00000618035.4 [Q96I51-2]
ENST00000610322.5 [Q96I51-1]
ENST00000615250.1