FARP2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0071800Biological processpodosome assembly
GO_0033623Biological processregulation of integrin activation
GO_0022405Biological processhair cycle process
GO_0030036Biological processactin cytoskeleton organization
GO_0071526Biological processsemaphorin-plexin signaling pathway
GO_0007155Biological processcell adhesion
GO_0016322Biological processneuron remodeling
GO_0016601Biological processRac protein signal transduction
GO_0030316Biological processosteoclast differentiation
GO_0005856Cellular componentcytoskeleton
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0005085Molecular functionguanyl-nucleotide exchange factor activity
GO_0008092Molecular functioncytoskeletal protein binding

IV. Literature review

[source]
Gene nameFARP2
Protein nameFERM, ARH/RhoGEF and pleckstrin domain protein 2
FARP2
FERM, ARHGEF and pleckstrin domain-containing protein 2 (FERM domain-including RhoGEF) (FIR) (FERM, RhoGEF and pleckstrin domain-containing protein 2) (Pleckstrin homology domain-containing family C member 3) (PH domain-containing family C member 3)
SynonymsPLEKHC3
KIAA0793
DescriptionFUNCTION: Functions as a guanine nucleotide exchange factor that activates RAC1. May have relatively low activity. Plays a role in the response to class 3 semaphorins and remodeling of the actin cytoskeleton. Plays a role in TNFSF11-mediated osteoclast differentiation, especially in podosome rearrangement and reorganization of the actin cytoskeleton. Regulates the activation of ITGB3, integrin signaling and cell adhesion (By similarity). .

AccessionsENST00000373287.8 [O94887-2]
O94887
ENST00000445489.1
ENST00000418082.1
H7C210
C9JWM9
H7C3M7
ENST00000444371.1
A0A2X0SSL3
ENST00000264042.8 [O94887-1]
ENST00000422951.1
ENST00000413432.2
H7C447
C9JVQ5
H7C3E4
ENST00000627550.2 [O94887-3]
ENST00000412332.1