Name | Number of supported studies | Average coverage | |
---|---|---|---|
endothelial cell | 16 studies | 27% ± 13% | |
ciliated cell | 14 studies | 34% ± 12% | |
microglial cell | 10 studies | 29% ± 9% | |
type I pneumocyte | 9 studies | 29% ± 12% | |
macrophage | 9 studies | 32% ± 12% | |
oligodendrocyte precursor cell | 9 studies | 25% ± 11% | |
adipocyte | 9 studies | 28% ± 7% | |
astrocyte | 9 studies | 28% ± 11% | |
oligodendrocyte | 9 studies | 27% ± 8% | |
glutamatergic neuron | 8 studies | 42% ± 25% | |
myeloid cell | 7 studies | 24% ± 3% | |
basal cell | 7 studies | 27% ± 18% | |
fibroblast | 7 studies | 26% ± 11% | |
GABAergic neuron | 7 studies | 41% ± 21% | |
interneuron | 6 studies | 37% ± 23% | |
epithelial cell | 6 studies | 39% ± 19% | |
club cell | 6 studies | 28% ± 12% | |
type II pneumocyte | 6 studies | 26% ± 8% | |
neuron | 5 studies | 26% ± 12% | |
dendritic cell | 5 studies | 22% ± 7% | |
endothelial cell of lymphatic vessel | 5 studies | 27% ± 11% | |
lymphocyte | 4 studies | 23% ± 7% | |
respiratory goblet cell | 4 studies | 27% ± 14% | |
monocyte | 4 studies | 26% ± 3% | |
erythrocyte | 4 studies | 42% ± 15% | |
pericyte | 4 studies | 27% ± 12% | |
smooth muscle cell | 4 studies | 21% ± 3% | |
classical monocyte | 3 studies | 23% ± 5% | |
non-classical monocyte | 3 studies | 21% ± 7% | |
GABAergic interneuron | 3 studies | 22% ± 4% | |
granule cell | 3 studies | 22% ± 3% | |
squamous epithelial cell | 3 studies | 37% ± 17% | |
cardiac muscle cell | 3 studies | 17% ± 1% | |
retinal rod cell | 3 studies | 21% ± 5% | |
hepatocyte | 3 studies | 34% ± 21% | |
abnormal cell | 3 studies | 23% ± 9% | |
T cell | 3 studies | 20% ± 3% | |
alveolar macrophage | 3 studies | 29% ± 9% | |
transit amplifying cell | 3 studies | 38% ± 28% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
esophagus | 100% | 3565.30 | 1445 / 1445 | 100% | 20.89 | 183 / 183 |
lung | 100% | 4405.10 | 578 / 578 | 100% | 14.58 | 1155 / 1155 |
breast | 100% | 3670.65 | 459 / 459 | 100% | 19.66 | 1115 / 1118 |
stomach | 100% | 2360.43 | 359 / 359 | 100% | 12.74 | 285 / 286 |
uterus | 100% | 3446.84 | 170 / 170 | 100% | 12.51 | 457 / 459 |
brain | 100% | 2406.45 | 2629 / 2642 | 100% | 16.87 | 705 / 705 |
intestine | 100% | 3184.65 | 966 / 966 | 99% | 11.49 | 524 / 527 |
prostate | 100% | 3151.49 | 245 / 245 | 99% | 11.14 | 499 / 502 |
thymus | 100% | 4703.79 | 653 / 653 | 99% | 14.04 | 601 / 605 |
bladder | 100% | 3141.76 | 21 / 21 | 99% | 11.17 | 498 / 504 |
pancreas | 99% | 1523.70 | 326 / 328 | 99% | 10.54 | 176 / 178 |
ovary | 100% | 3447.82 | 180 / 180 | 98% | 8.34 | 422 / 430 |
kidney | 100% | 2289.57 | 89 / 89 | 97% | 11.15 | 873 / 901 |
skin | 100% | 4741.35 | 1809 / 1809 | 96% | 12.99 | 454 / 472 |
adrenal gland | 100% | 2982.12 | 258 / 258 | 95% | 10.07 | 219 / 230 |
liver | 100% | 1626.09 | 226 / 226 | 83% | 5.15 | 338 / 406 |
adipose | 100% | 3588.04 | 1204 / 1204 | 0% | 0 | 0 / 0 |
blood vessel | 100% | 3414.58 | 1335 / 1335 | 0% | 0 | 0 / 0 |
lymph node | 0% | 0 | 0 / 0 | 100% | 11.79 | 29 / 29 |
muscle | 100% | 3509.60 | 803 / 803 | 0% | 0 | 0 / 0 |
spleen | 100% | 3543.28 | 241 / 241 | 0% | 0 | 0 / 0 |
tonsil | 0% | 0 | 0 / 0 | 100% | 15.46 | 45 / 45 |
ureter | 0% | 0 | 0 / 0 | 100% | 7.13 | 1 / 1 |
peripheral blood | 98% | 2555.92 | 909 / 929 | 0% | 0 | 0 / 0 |
heart | 98% | 2057.69 | 841 / 861 | 0% | 0 | 0 / 0 |
eye | 0% | 0 | 0 / 0 | 84% | 7.24 | 67 / 80 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
GO_0006897 | Biological process | endocytosis |
GO_0051223 | Biological process | regulation of protein transport |
GO_0005768 | Cellular component | endosome |
GO_0005829 | Cellular component | cytosol |
GO_0005886 | Cellular component | plasma membrane |
GO_0030139 | Cellular component | endocytic vesicle |
GO_0045296 | Molecular function | cadherin binding |
GO_0005085 | Molecular function | guanyl-nucleotide exchange factor activity |
GO_0005515 | Molecular function | protein binding |
GO_0032794 | Molecular function | GTPase activating protein binding |
GO_0031267 | Molecular function | small GTPase binding |
GO_0005096 | Molecular function | GTPase activator activity |
Gene name | GAPVD1 |
Protein name | GTPase activating protein and VPS9 domains 1 GTPase-activating protein and VPS9 domain-containing protein 1 (GAPex-5) (Rab5-activating protein 6) |
Synonyms | RAP6 KIAA1521 GAPEX5 |
Description | FUNCTION: Acts both as a GTPase-activating protein (GAP) and a guanine nucleotide exchange factor (GEF), and participates in various processes such as endocytosis, insulin receptor internalization or LC2A4/GLUT4 trafficking. Acts as a GEF for the Ras-related protein RAB31 by exchanging bound GDP for free GTP, leading to regulate LC2A4/GLUT4 trafficking. In the absence of insulin, it maintains RAB31 in an active state and promotes a futile cycle between LC2A4/GLUT4 storage vesicles and early endosomes, retaining LC2A4/GLUT4 inside the cells. Upon insulin stimulation, it is translocated to the plasma membrane, releasing LC2A4/GLUT4 from intracellular storage vesicles. Also involved in EGFR trafficking and degradation, possibly by promoting EGFR ubiquitination and subsequent degradation by the proteasome. Has GEF activity for Rab5 and GAP activity for Ras. . |
Accessions | ENST00000394105.6 [Q14C86-6] ENST00000467750.5 B0QZ65 H0Y7I9 ENST00000394104.6 [Q14C86-1] C9IZX9 Q14C86 F8W9S7 ENST00000495955.5 [Q14C86-1] ENST00000470056.5 [Q14C86-3] C9IZ08 ENST00000297933.11 [Q14C86-2] ENST00000497580.5 ENST00000394084.5 ENST00000461379.5 ENST00000312123.13 [Q14C86-4] ENST00000436712.2 ENST00000394083.6 H0Y4E7 B4DGD8 ENST00000431329.5 |