FGD4 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0046847Biological processfilopodium assembly
GO_0051056Biological processregulation of small GTPase mediated signal transduction
GO_0008360Biological processregulation of cell shape
GO_0030036Biological processactin cytoskeleton organization
GO_0043087Biological processregulation of GTPase activity
GO_0007010Biological processcytoskeleton organization
GO_0001726Cellular componentruffle
GO_0030175Cellular componentfilopodium
GO_0005856Cellular componentcytoskeleton
GO_0005829Cellular componentcytosol
GO_0030027Cellular componentlamellipodium
GO_0005794Cellular componentGolgi apparatus
GO_0005737Cellular componentcytoplasm
GO_0005085Molecular functionguanyl-nucleotide exchange factor activity
GO_0003779Molecular functionactin binding
GO_0031267Molecular functionsmall GTPase binding
GO_0046872Molecular functionmetal ion binding

IV. Literature review

[source]
Gene nameFGD4
Protein nameFYVE, RhoGEF and PH domain-containing protein 4
Alternative protein FGD4
FGD4 protein
FGD4
FYVE, RhoGEF and PH domain-containing protein 4 (Actin filament-binding protein frabin) (FGD1-related F-actin-binding protein) (Zinc finger FYVE domain-containing protein 6)
FYVE, RhoGEF and PH domain containing 4 (cDNA FLJ55905, highly similar to FYVE, RhoGEF and PH domain-containing protein 4)
FYVE, RhoGEF and PH domain containing 4
SynonymsZFYVE6
FRABP
DescriptionFUNCTION: Activates CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP. Plays a role in regulating the actin cytoskeleton and cell shape. Activates MAPK8 (By similarity). .

AccessionsENST00000534526.7
ENST00000583694.2 [Q96M96-1]
Q96M96
ENST00000493087.5
F8VVF1
J3KSS3
ENST00000531134.7
A0A804HK93
E9PJX4
ENST00000494977.1
ENST00000546442.5
E9PNX0
ENST00000525053.6 [Q96M96-1]
ENST00000683182.1
ENST00000395740.5
ENST00000525053
A0A2X0U2J9
H0YDQ0
L8EAP1
E9PQT1
F8W1R0
ENST00000583694
B7Z493
ENST00000472289.5
Q49A55
ENST00000427716.7 [Q96M96-1]
ENST00000682739.1
ENST00000551984.5
F8VWL3