Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| macrophage | 24 studies | 37% ± 19% | |
| endothelial cell | 24 studies | 35% ± 15% | |
| astrocyte | 16 studies | 50% ± 20% | |
| microglial cell | 15 studies | 62% ± 21% | |
| classical monocyte | 13 studies | 23% ± 6% | |
| pericyte | 13 studies | 29% ± 12% | |
| non-classical monocyte | 10 studies | 24% ± 9% | |
| myeloid cell | 10 studies | 43% ± 15% | |
| oligodendrocyte | 10 studies | 28% ± 12% | |
| epithelial cell | 9 studies | 36% ± 19% | |
| adipocyte | 9 studies | 39% ± 14% | |
| monocyte | 8 studies | 46% ± 20% | |
| type I pneumocyte | 8 studies | 48% ± 21% | |
| GABAergic neuron | 8 studies | 37% ± 11% | |
| dendritic cell | 8 studies | 36% ± 17% | |
| fibroblast | 8 studies | 30% ± 11% | |
| retinal cone cell | 7 studies | 50% ± 18% | |
| retinal rod cell | 7 studies | 53% ± 31% | |
| interneuron | 6 studies | 46% ± 15% | |
| retina horizontal cell | 6 studies | 23% ± 11% | |
| Mueller cell | 6 studies | 48% ± 19% | |
| type II pneumocyte | 6 studies | 44% ± 15% | |
| neutrophil | 6 studies | 30% ± 16% | |
| conventional dendritic cell | 5 studies | 21% ± 1% | |
| glutamatergic neuron | 5 studies | 40% ± 13% | |
| cardiac muscle cell | 5 studies | 47% ± 15% | |
| mesothelial cell | 5 studies | 33% ± 10% | |
| smooth muscle cell | 5 studies | 27% ± 11% | |
| ciliated cell | 5 studies | 30% ± 9% | |
| basal cell | 5 studies | 41% ± 23% | |
| mononuclear phagocyte | 4 studies | 36% ± 14% | |
| cholangiocyte | 4 studies | 63% ± 13% | |
| neuron | 4 studies | 39% ± 15% | |
| oligodendrocyte precursor cell | 4 studies | 24% ± 7% | |
| retinal pigment epithelial cell | 4 studies | 32% ± 14% | |
| capillary endothelial cell | 4 studies | 24% ± 7% | |
| club cell | 4 studies | 33% ± 6% | |
| hepatic stellate cell | 3 studies | 29% ± 14% | |
| GABAergic interneuron | 3 studies | 28% ± 13% | |
| glial cell | 3 studies | 24% ± 2% | |
| endothelial cell of artery | 3 studies | 25% ± 9% | |
| amacrine cell | 3 studies | 22% ± 6% | |
| glycinergic amacrine cell | 3 studies | 18% ± 2% | |
| retinal ganglion cell | 3 studies | 40% ± 10% | |
| endothelial cell of vascular tree | 3 studies | 47% ± 11% | |
| hepatocyte | 3 studies | 65% ± 18% | |
| alveolar macrophage | 3 studies | 56% ± 6% | |
| respiratory goblet cell | 3 studies | 42% ± 12% | |
| transit amplifying cell | 3 studies | 43% ± 37% | |
| kidney loop of Henle epithelial cell | 3 studies | 58% ± 30% | |
| mucus secreting cell | 3 studies | 47% ± 7% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| kidney | 100% | 1724.80 | 89 / 89 | 99% | 14.90 | 895 / 901 |
| esophagus | 100% | 1877.73 | 1442 / 1445 | 98% | 14.52 | 179 / 183 |
| stomach | 100% | 4170.13 | 359 / 359 | 97% | 11.84 | 278 / 286 |
| ovary | 100% | 4708.37 | 180 / 180 | 97% | 6.75 | 416 / 430 |
| pancreas | 99% | 1473.88 | 326 / 328 | 97% | 13.37 | 172 / 178 |
| lung | 99% | 3208.58 | 575 / 578 | 95% | 8.11 | 1103 / 1155 |
| intestine | 97% | 1978.89 | 938 / 966 | 97% | 9.90 | 510 / 527 |
| brain | 94% | 1256.09 | 2492 / 2642 | 99% | 8.24 | 697 / 705 |
| prostate | 98% | 1383.78 | 240 / 245 | 95% | 6.66 | 476 / 502 |
| skin | 99% | 2479.94 | 1791 / 1809 | 93% | 11.63 | 437 / 472 |
| breast | 100% | 3272.08 | 459 / 459 | 90% | 5.75 | 1007 / 1118 |
| thymus | 100% | 1943.45 | 652 / 653 | 90% | 6.09 | 543 / 605 |
| uterus | 93% | 1058.39 | 158 / 170 | 86% | 5.31 | 394 / 459 |
| liver | 96% | 1871.39 | 217 / 226 | 83% | 6.43 | 335 / 406 |
| bladder | 95% | 1242.29 | 20 / 21 | 78% | 4.84 | 395 / 504 |
| adrenal gland | 91% | 1067.20 | 236 / 258 | 72% | 3.76 | 165 / 230 |
| adipose | 100% | 3997.10 | 1204 / 1204 | 0% | 0 | 0 / 0 |
| blood vessel | 100% | 2650.72 | 1330 / 1335 | 0% | 0 | 0 / 0 |
| muscle | 99% | 2481.92 | 797 / 803 | 0% | 0 | 0 / 0 |
| spleen | 98% | 1479.16 | 237 / 241 | 0% | 0 | 0 / 0 |
| heart | 95% | 1135.60 | 818 / 861 | 0% | 0 | 0 / 0 |
| tonsil | 0% | 0 | 0 / 0 | 87% | 5.11 | 39 / 45 |
| peripheral blood | 78% | 2162.95 | 729 / 929 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 75% | 5.99 | 60 / 80 |
| lymph node | 0% | 0 | 0 / 0 | 28% | 0.84 | 8 / 29 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
| GO_0046847 | Biological process | filopodium assembly |
| GO_0051056 | Biological process | regulation of small GTPase mediated signal transduction |
| GO_0008360 | Biological process | regulation of cell shape |
| GO_0030036 | Biological process | actin cytoskeleton organization |
| GO_0043087 | Biological process | regulation of GTPase activity |
| GO_0007010 | Biological process | cytoskeleton organization |
| GO_0001726 | Cellular component | ruffle |
| GO_0030175 | Cellular component | filopodium |
| GO_0005856 | Cellular component | cytoskeleton |
| GO_0005829 | Cellular component | cytosol |
| GO_0030027 | Cellular component | lamellipodium |
| GO_0005794 | Cellular component | Golgi apparatus |
| GO_0005737 | Cellular component | cytoplasm |
| GO_0005085 | Molecular function | guanyl-nucleotide exchange factor activity |
| GO_0003779 | Molecular function | actin binding |
| GO_0031267 | Molecular function | small GTPase binding |
| GO_0046872 | Molecular function | metal ion binding |
| Gene name | FGD4 |
| Protein name | FYVE, RhoGEF and PH domain-containing protein 4 Alternative protein FGD4 FGD4 protein FGD4 FYVE, RhoGEF and PH domain-containing protein 4 (Actin filament-binding protein frabin) (FGD1-related F-actin-binding protein) (Zinc finger FYVE domain-containing protein 6) FYVE, RhoGEF and PH domain containing 4 (cDNA FLJ55905, highly similar to FYVE, RhoGEF and PH domain-containing protein 4) FYVE, RhoGEF and PH domain containing 4 |
| Synonyms | ZFYVE6 FRABP |
| Description | FUNCTION: Activates CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP. Plays a role in regulating the actin cytoskeleton and cell shape. Activates MAPK8 (By similarity). . |
| Accessions | ENST00000534526.7 ENST00000583694.2 [Q96M96-1] Q96M96 ENST00000493087.5 F8VVF1 J3KSS3 ENST00000531134.7 A0A804HK93 E9PJX4 ENST00000494977.1 ENST00000546442.5 E9PNX0 ENST00000525053.6 [Q96M96-1] ENST00000683182.1 ENST00000395740.5 ENST00000525053 A0A2X0U2J9 H0YDQ0 L8EAP1 E9PQT1 F8W1R0 ENST00000583694 B7Z493 ENST00000472289.5 Q49A55 ENST00000427716.7 [Q96M96-1] ENST00000682739.1 ENST00000551984.5 F8VWL3 |