RHOD report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of RHOD at tissue level.

III. Associated gene sets

GO_0030032Biological processlamellipodium assembly
GO_0007165Biological processsignal transduction
GO_0051056Biological processregulation of small GTPase mediated signal transduction
GO_0045785Biological processpositive regulation of cell adhesion
GO_0051017Biological processactin filament bundle assembly
GO_0030335Biological processpositive regulation of cell migration
GO_0007015Biological processactin filament organization
GO_0048041Biological processfocal adhesion assembly
GO_0007266Biological processRho protein signal transduction
GO_0016477Biological processcell migration
GO_0032956Biological processregulation of actin cytoskeleton organization
GO_0005886Cellular componentplasma membrane
GO_0005769Cellular componentearly endosome
GO_0000139Cellular componentGolgi membrane
GO_0005829Cellular componentcytosol
GO_0005741Cellular componentmitochondrial outer membrane
GO_0010008Cellular componentendosome membrane
GO_0005085Molecular functionguanyl-nucleotide exchange factor activity
GO_0019901Molecular functionprotein kinase binding
GO_0005525Molecular functionGTP binding
GO_0003924Molecular functionGTPase activity

IV. Literature review

[source]
Gene nameRHOD
Protein nameRho-related GTP-binding protein RhoD (Rho-related protein HP1) (RhoHP1)
Ras homolog family member D
SynonymsARHD
DescriptionFUNCTION: Involved in endosome dynamics. May coordinate membrane transport with the function of the cytoskeleton. Involved in the internalization and trafficking of activated tyrosine kinase receptors such as PDGFRB. Participates in the reorganization of actin cytoskeleton; the function seems to involve WHAMM and includes regulation of filopodia formation and actin filament bundling. Can modulate the effect of DAPK3 in reorganization of actin cytoskeleton and focal adhesion dissolution. .

AccessionsENST00000308831.7
ENST00000532559.1
O00212
A0A0B6XJZ9
E9PIG5