ARHGEF3 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
endothelial cell	25 studies	33% ± 11%	Explore
natural killer cell	23 studies	27% ± 10%	Explore
CD16-positive, CD56-dim natural killer cell, human	15 studies	30% ± 11%	Explore
CD8-positive, alpha-beta T cell	15 studies	23% ± 8%	Explore
astrocyte	15 studies	29% ± 14%	Explore
regulatory T cell	14 studies	22% ± 7%	Explore
T cell	11 studies	31% ± 11%	Explore
CD4-positive, alpha-beta T cell	11 studies	23% ± 8%	Explore
glutamatergic neuron	11 studies	45% ± 25%	Explore
gamma-delta T cell	11 studies	21% ± 4%	Explore
oligodendrocyte precursor cell	10 studies	32% ± 12%	Explore
mature NK T cell	9 studies	23% ± 8%	Explore
capillary endothelial cell	9 studies	27% ± 12%	Explore
CD16-negative, CD56-bright natural killer cell, human	9 studies	24% ± 6%	Explore
mast cell	9 studies	34% ± 11%	Explore
GABAergic neuron	8 studies	37% ± 18%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	8 studies	18% ± 2%	Explore
mucosal invariant T cell	8 studies	23% ± 8%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	8 studies	23% ± 11%	Explore
oligodendrocyte	7 studies	27% ± 11%	Explore
CD8-positive, alpha-beta memory T cell	6 studies	22% ± 4%	Explore
effector memory CD8-positive, alpha-beta T cell	6 studies	25% ± 7%	Explore
endothelial cell of vascular tree	6 studies	30% ± 13%	Explore
endothelial cell of lymphatic vessel	6 studies	30% ± 9%	Explore
CD4-positive, alpha-beta memory T cell	5 studies	17% ± 2%	Explore
podocyte	5 studies	65% ± 18%	Explore
epithelial cell	5 studies	45% ± 24%	Explore
fibroblast	5 studies	26% ± 4%	Explore
dendritic cell	5 studies	20% ± 2%	Explore
vein endothelial cell	5 studies	37% ± 25%	Explore
T follicular helper cell	5 studies	18% ± 2%	Explore
macrophage	5 studies	18% ± 2%	Explore
monocyte	5 studies	31% ± 12%	Explore
neuron	4 studies	28% ± 8%	Explore
lymphocyte	4 studies	38% ± 13%	Explore
type II pneumocyte	4 studies	22% ± 3%	Explore
basal cell	4 studies	41% ± 26%	Explore
interneuron	4 studies	44% ± 20%	Explore
cardiac muscle cell	3 studies	19% ± 5%	Explore
mesothelial cell	3 studies	30% ± 1%	Explore
Mueller cell	3 studies	21% ± 6%	Explore
amacrine cell	3 studies	40% ± 10%	Explore
retinal pigment epithelial cell	3 studies	48% ± 23%	Explore
effector memory CD4-positive, alpha-beta T cell	3 studies	20% ± 2%	Explore
abnormal cell	3 studies	27% ± 8%	Explore
alveolar macrophage	3 studies	40% ± 5%	Explore
club cell	3 studies	28% ± 7%	Explore
granule cell	3 studies	31% ± 12%	Explore
double negative thymocyte	3 studies	24% ± 3%	Explore
effector memory CD8-positive, alpha-beta T cell, terminally differentiated	3 studies	32% ± 10%	Explore
mucus secreting cell	3 studies	47% ± 14%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
brain	14 studies	34% ± 18%	Explore
peripheral blood	5 studies	17% ± 1%	Explore
lung	5 studies	23% ± 4%	Explore
kidney	4 studies	22% ± 5%	Explore
adipose	3 studies	21% ± 4%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
pancreas	100%	2187.09	328 / 328	100%	19.75	178 / 178
breast	100%	2400.61	459 / 459	100%	29.34	1114 / 1118
lung	100%	3066.76	578 / 578	100%	17.05	1150 / 1155
thymus	100%	1739.33	653 / 653	99%	18.74	601 / 605
ovary	100%	3237.86	180 / 180	99%	28.41	427 / 430
adrenal gland	100%	4952.63	258 / 258	99%	39.38	228 / 230
esophagus	100%	1629.17	1439 / 1445	99%	16.27	182 / 183
prostate	100%	1984.52	245 / 245	99%	21.50	496 / 502
uterus	100%	3836.24	170 / 170	98%	18.64	450 / 459
stomach	99%	1158.45	357 / 359	98%	14.08	281 / 286
kidney	100%	3378.30	89 / 89	98%	16.73	879 / 901
intestine	100%	1882.67	963 / 966	98%	12.58	515 / 527
brain	97%	2171.93	2557 / 2642	100%	26.28	704 / 705
bladder	100%	1956.43	21 / 21	95%	12.52	481 / 504
skin	84%	1361.82	1525 / 1809	87%	12.58	411 / 472
adipose	100%	2706.79	1204 / 1204	0%	0	0 / 0
spleen	100%	2132.62	241 / 241	0%	0	0 / 0
ureter	0%	0	0 / 0	100%	4.11	1 / 1
tonsil	0%	0	0 / 0	98%	24.12	44 / 45
heart	96%	887.99	823 / 861	0%	0	0 / 0
peripheral blood	95%	1655.68	880 / 929	0%	0	0 / 0
muscle	91%	757.95	729 / 803	0%	0	0 / 0
lymph node	0%	0	0 / 0	90%	25.06	26 / 29
blood vessel	88%	957.43	1172 / 1335	0%	0	0 / 0
liver	10%	53.73	23 / 226	50%	5.54	201 / 406
eye	0%	0	0 / 0	16%	1.04	13 / 80
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0007266	Biological process	Rho protein signal transduction
GO_0051056	Biological process	regulation of small GTPase mediated signal transduction
GO_0035025	Biological process	positive regulation of Rho protein signal transduction
GO_0005829	Cellular component	cytosol
GO_0005085	Molecular function	guanyl-nucleotide exchange factor activity
GO_0005515	Molecular function	protein binding

IV. Literature review

[source]

Gene name	ARHGEF3
Protein name	Rho guanine nucleotide exchange factor 3 Rho guanine nucleotide exchange factor 3 (Exchange factor found in platelets and leukemic and neuronal tissues) (XPLN)
Synonyms
Description	FUNCTION: Acts as a guanine nucleotide exchange factor (GEF) for RhoA and RhoB GTPases. . FUNCTION: Acts as a guanine nucleotide exchange factor (GEF) for RhoA and RhoB GTPases. . FUNCTION: Acts as a guanine nucleotide exchange factor (GEF) for RhoA and RhoB GTPases. .
Accessions	C9J609 C9J586 ENST00000296315.8 [Q9NR81-1] ENST00000468466.1 C9J5K8 F8WC29 Q9NR81 ENST00000468727.5 ENST00000465659.5 ENST00000477833.5 ENST00000495373.5 F8WDB7 ENST00000473779.5 C9JNF2 H7C4P0 ENST00000497267.5 E7EU49 ENST00000413728.6 [Q9NR81-3] ENST00000338458.8 [Q9NR81-2] ENST00000496106.5 E9PG37 ENST00000486829.1

ARHGEF3 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review