SEC61B | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
B cell	42 studies	45% ± 17%	Explore
fibroblast	38 studies	57% ± 20%	Explore
natural killer cell	37 studies	50% ± 11%	Explore
CD8-positive, alpha-beta T cell	35 studies	49% ± 20%	Explore
endothelial cell	34 studies	50% ± 18%	Explore
macrophage	33 studies	57% ± 14%	Explore
CD4-positive, alpha-beta T cell	32 studies	46% ± 18%	Explore
T cell	30 studies	47% ± 14%	Explore
plasmacytoid dendritic cell	30 studies	91% ± 12%	Explore
pericyte	29 studies	52% ± 17%	Explore
plasma cell	28 studies	77% ± 19%	Explore
conventional dendritic cell	28 studies	68% ± 13%	Explore
classical monocyte	27 studies	60% ± 15%	Explore
smooth muscle cell	26 studies	50% ± 16%	Explore
dendritic cell	25 studies	64% ± 24%	Explore
regulatory T cell	25 studies	48% ± 16%	Explore
non-classical monocyte	24 studies	56% ± 17%	Explore
mast cell	21 studies	47% ± 15%	Explore
mature NK T cell	20 studies	45% ± 14%	Explore
memory B cell	20 studies	42% ± 11%	Explore
epithelial cell	20 studies	62% ± 19%	Explore
monocyte	19 studies	54% ± 15%	Explore
gamma-delta T cell	19 studies	49% ± 14%	Explore
basal cell	19 studies	57% ± 18%	Explore
naive B cell	19 studies	33% ± 11%	Explore
connective tissue cell	19 studies	60% ± 19%	Explore
endothelial cell of lymphatic vessel	18 studies	63% ± 13%	Explore
CD16-negative, CD56-bright natural killer cell, human	16 studies	44% ± 16%	Explore
mucosal invariant T cell	16 studies	48% ± 16%	Explore
CD16-positive, CD56-dim natural killer cell, human	15 studies	54% ± 11%	Explore
ciliated cell	15 studies	64% ± 15%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	15 studies	35% ± 9%	Explore
myofibroblast cell	14 studies	58% ± 19%	Explore
myeloid cell	14 studies	59% ± 22%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	13 studies	44% ± 16%	Explore
plasmablast	12 studies	82% ± 14%	Explore
CD8-positive, alpha-beta memory T cell	12 studies	52% ± 17%	Explore
secretory cell	12 studies	64% ± 18%	Explore
capillary endothelial cell	12 studies	44% ± 14%	Explore
endothelial cell of artery	12 studies	52% ± 18%	Explore
CD4-positive, alpha-beta memory T cell	11 studies	52% ± 18%	Explore
goblet cell	11 studies	50% ± 19%	Explore
vein endothelial cell	11 studies	53% ± 15%	Explore
endothelial cell of vascular tree	11 studies	53% ± 12%	Explore
innate lymphoid cell	10 studies	50% ± 13%	Explore
effector memory CD8-positive, alpha-beta T cell	10 studies	51% ± 14%	Explore
progenitor cell	10 studies	62% ± 19%	Explore
abnormal cell	10 studies	57% ± 20%	Explore
mesothelial cell	10 studies	66% ± 18%	Explore
type I pneumocyte	9 studies	43% ± 19%	Explore
type II pneumocyte	9 studies	59% ± 25%	Explore
club cell	9 studies	57% ± 22%	Explore
IgG plasma cell	9 studies	67% ± 22%	Explore
leukocyte	8 studies	55% ± 7%	Explore
IgA plasma cell	8 studies	72% ± 25%	Explore
T follicular helper cell	8 studies	46% ± 8%	Explore
neutrophil	7 studies	32% ± 10%	Explore
effector CD8-positive, alpha-beta T cell	7 studies	63% ± 19%	Explore
epithelial cell of proximal tubule	7 studies	51% ± 13%	Explore
neuron	7 studies	51% ± 24%	Explore
erythrocyte	7 studies	45% ± 21%	Explore
alveolar macrophage	6 studies	56% ± 17%	Explore
hematopoietic precursor cell	6 studies	64% ± 26%	Explore
respiratory goblet cell	6 studies	54% ± 24%	Explore
platelet	6 studies	23% ± 10%	Explore
effector CD4-positive, alpha-beta T cell	6 studies	64% ± 23%	Explore
mononuclear phagocyte	6 studies	57% ± 21%	Explore
kidney loop of Henle epithelial cell	6 studies	44% ± 5%	Explore
renal alpha-intercalated cell	6 studies	66% ± 5%	Explore
enterocyte	6 studies	44% ± 12%	Explore
hematopoietic stem cell	6 studies	65% ± 5%	Explore
precursor B cell	6 studies	59% ± 10%	Explore
astrocyte	6 studies	29% ± 17%	Explore
effector memory CD4-positive, alpha-beta T cell	6 studies	59% ± 20%	Explore
CD4-positive helper T cell	5 studies	39% ± 13%	Explore
central memory CD8-positive, alpha-beta T cell	5 studies	42% ± 17%	Explore
effector memory CD8-positive, alpha-beta T cell, terminally differentiated	5 studies	43% ± 16%	Explore
exhausted T cell	5 studies	68% ± 14%	Explore
ionocyte	5 studies	55% ± 8%	Explore
enteroendocrine cell	5 studies	65% ± 22%	Explore
transit amplifying cell	5 studies	42% ± 18%	Explore
pro-B cell	5 studies	51% ± 17%	Explore
brush cell	5 studies	34% ± 22%	Explore
neuroendocrine cell	5 studies	70% ± 20%	Explore
T-helper 17 cell	5 studies	61% ± 19%	Explore
immature B cell	5 studies	52% ± 16%	Explore
mucus secreting cell	5 studies	57% ± 25%	Explore
intermediate monocyte	5 studies	73% ± 9%	Explore
hepatocyte	5 studies	50% ± 29%	Explore
granulocyte	5 studies	47% ± 11%	Explore
CD4-positive, alpha-beta cytotoxic T cell	4 studies	55% ± 24%	Explore
pancreatic A cell	4 studies	85% ± 9%	Explore
type B pancreatic cell	4 studies	85% ± 8%	Explore
glomerular endothelial cell	4 studies	39% ± 7%	Explore
kidney distal convoluted tubule epithelial cell	4 studies	63% ± 8%	Explore
intestinal crypt stem cell	4 studies	47% ± 16%	Explore
erythroblast	4 studies	66% ± 20%	Explore
microglial cell	4 studies	36% ± 16%	Explore
adventitial cell	4 studies	60% ± 9%	Explore
acinar cell	4 studies	71% ± 23%	Explore
muscle cell	4 studies	41% ± 21%	Explore
luminal hormone-sensing cell of mammary gland	4 studies	79% ± 5%	Explore
luminal cell of prostate epithelium	4 studies	59% ± 23%	Explore
IgM plasma cell	4 studies	62% ± 22%	Explore
group 3 innate lymphoid cell	4 studies	60% ± 12%	Explore
T-helper 1 cell	4 studies	64% ± 16%	Explore
deuterosomal cell	3 studies	64% ± 5%	Explore
duct epithelial cell	3 studies	74% ± 0%	Explore
precursor cell	3 studies	75% ± 9%	Explore
pancreatic D cell	3 studies	85% ± 9%	Explore
monocyte-derived dendritic cell	3 studies	68% ± 20%	Explore
podocyte	3 studies	64% ± 11%	Explore
neural crest cell	3 studies	58% ± 5%	Explore
renal principal cell	3 studies	54% ± 5%	Explore
thymocyte	3 studies	46% ± 32%	Explore
extravillous trophoblast	3 studies	82% ± 5%	Explore
placental villous trophoblast	3 studies	80% ± 3%	Explore
lymphocyte	3 studies	67% ± 9%	Explore
megakaryocyte	3 studies	47% ± 5%	Explore
amacrine cell	3 studies	43% ± 16%	Explore
retina horizontal cell	3 studies	39% ± 18%	Explore
retinal cone cell	3 studies	59% ± 21%	Explore
retinal pigment epithelial cell	3 studies	37% ± 27%	Explore
retinal rod cell	3 studies	35% ± 14%	Explore
serous secreting cell	3 studies	76% ± 17%	Explore
intraepithelial lymphocyte	3 studies	47% ± 18%	Explore
Mueller cell	3 studies	36% ± 7%	Explore
cardiac muscle cell	3 studies	17% ± 2%	Explore
oligodendrocyte	3 studies	23% ± 6%	Explore
germinal center B cell	3 studies	62% ± 5%	Explore
myoepithelial cell	3 studies	54% ± 12%	Explore
inflammatory macrophage	3 studies	38% ± 13%	Explore
GABAergic neuron	3 studies	22% ± 5%	Explore
glutamatergic neuron	3 studies	30% ± 9%	Explore
pancreatic ductal cell	3 studies	76% ± 8%	Explore
oligodendrocyte precursor cell	3 studies	43% ± 14%	Explore
granulocyte monocyte progenitor cell	3 studies	62% ± 28%	Explore
megakaryocyte-erythroid progenitor cell	3 studies	80% ± 12%	Explore
glial cell	3 studies	54% ± 21%	Explore
keratinocyte	3 studies	55% ± 7%	Explore
central memory CD4-positive, alpha-beta T cell	3 studies	47% ± 10%	Explore
double negative thymocyte	3 studies	69% ± 15%	Explore
progenitor cell of mammary luminal epithelium	3 studies	72% ± 6%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
peripheral blood	21 studies	49% ± 15%	Explore
lung	18 studies	56% ± 15%	Explore
intestine	13 studies	46% ± 21%	Explore
kidney	9 studies	49% ± 14%	Explore
eye	8 studies	33% ± 16%	Explore
brain	7 studies	31% ± 9%	Explore
lymph node	6 studies	48% ± 19%	Explore
bone marrow	6 studies	44% ± 15%	Explore
liver	6 studies	48% ± 18%	Explore
pancreas	5 studies	73% ± 24%	Explore
uterus	5 studies	61% ± 21%	Explore
placenta	4 studies	64% ± 21%	Explore
prostate	4 studies	52% ± 8%	Explore
breast	4 studies	62% ± 5%	Explore
heart	3 studies	27% ± 11%	Explore
adrenal gland	3 studies	51% ± 9%	Explore
esophagus	3 studies	55% ± 26%	Explore
skin	3 studies	47% ± 8%	Explore
stomach	3 studies	42% ± 28%	Explore
thymus	3 studies	68% ± 24%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
esophagus	100%	2321.86	1445 / 1445	100%	145.76	183 / 183
kidney	100%	3277.72	89 / 89	100%	156.79	901 / 901
liver	100%	4736.42	226 / 226	100%	280.39	406 / 406
ovary	100%	2938.25	180 / 180	100%	188.52	430 / 430
pancreas	100%	5753.91	328 / 328	100%	200.28	178 / 178
skin	100%	3042.29	1809 / 1809	100%	185.80	472 / 472
stomach	100%	2712.54	359 / 359	100%	183.95	286 / 286
uterus	100%	3132.65	170 / 170	100%	257.63	459 / 459
thymus	100%	3238.54	653 / 653	100%	242.78	604 / 605
intestine	100%	2436.74	966 / 966	100%	208.51	526 / 527
bladder	100%	2522.33	21 / 21	100%	202.19	503 / 504
lung	100%	3391.12	576 / 578	100%	195.80	1155 / 1155
prostate	100%	3375.19	245 / 245	100%	350.35	500 / 502
adrenal gland	100%	4326.34	258 / 258	100%	226.56	229 / 230
breast	100%	3036.89	459 / 459	100%	230.46	1113 / 1118
brain	99%	1503.94	2625 / 2642	100%	155.41	705 / 705
adipose	100%	3028.30	1204 / 1204	0%	0	0 / 0
eye	0%	0	0 / 0	100%	189.34	80 / 80
lymph node	0%	0	0 / 0	100%	471.87	29 / 29
spleen	100%	3250.49	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	219.27	45 / 45
ureter	0%	0	0 / 0	100%	175.38	1 / 1
blood vessel	100%	2912.26	1331 / 1335	0%	0	0 / 0
peripheral blood	97%	3159.38	900 / 929	0%	0	0 / 0
heart	96%	1287.08	830 / 861	0%	0	0 / 0
muscle	78%	657.39	629 / 803	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0030970	Biological process	retrograde protein transport, ER to cytosol
GO_0031204	Biological process	post-translational protein targeting to membrane, translocation
GO_0006616	Biological process	SRP-dependent cotranslational protein targeting to membrane, translocation
GO_0036503	Biological process	ERAD pathway
GO_0005784	Cellular component	Sec61 translocon complex
GO_0031205	Cellular component	endoplasmic reticulum Sec complex
GO_0005783	Cellular component	endoplasmic reticulum
GO_0005829	Cellular component	cytosol
GO_0016020	Cellular component	membrane
GO_0005789	Cellular component	endoplasmic reticulum membrane
GO_0044322	Cellular component	endoplasmic reticulum quality control compartment
GO_0043022	Molecular function	ribosome binding
GO_0005085	Molecular function	guanyl-nucleotide exchange factor activity
GO_0048408	Molecular function	epidermal growth factor binding
GO_0005515	Molecular function	protein binding
GO_0003723	Molecular function	RNA binding

IV. Literature review

[source]

Gene name	SEC61B
Protein name	SEC61 translocon subunit beta Protein transport protein Sec61 subunit beta
Synonyms
Description	FUNCTION: Component of SEC61 channel-forming translocon complex that mediates transport of signal peptide-containing precursor polypeptides across the endoplasmic reticulum (ER) . Forms a ribosome receptor and a gated pore in the ER membrane, both functions required for cotranslational translocation of nascent polypeptides . The SEC61 channel is also involved in ER membrane insertion of transmembrane proteins: it mediates membrane insertion of the first few transmembrane segments of proteins, while insertion of subsequent transmembrane regions of multi-pass membrane proteins is mediated by the multi-pass translocon (MPT) complex . The SEC61 channel cooperates with the translocating protein TRAM1 to import nascent proteins into the ER . .
Accessions	ENST00000498603.5 P60468 ENST00000223641.5 S4R3B5

SEC61B report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review