DENND4C report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0015031Biological processprotein transport
GO_0072659Biological processprotein localization to plasma membrane
GO_0032869Biological processcellular response to insulin stimulus
GO_0032483Biological processregulation of Rab protein signal transduction
GO_0043231Cellular componentintracellular membrane-bounded organelle
GO_0030904Cellular componentretromer complex
GO_0005829Cellular componentcytosol
GO_0032593Cellular componentinsulin-responsive compartment
GO_0005794Cellular componentGolgi apparatus
GO_0030659Cellular componentcytoplasmic vesicle membrane
GO_0005886Cellular componentplasma membrane
GO_0031410Cellular componentcytoplasmic vesicle
GO_0005085Molecular functionguanyl-nucleotide exchange factor activity

IV. Literature review

[source]
Gene nameDENND4C
Protein nameDENN domain containing 4C
DENN domain-containing protein 4C
SynonymsC9orf55B
C9orf55
DescriptionFUNCTION: Guanine nucleotide exchange factor (GEF) activating RAB10. Promotes the exchange of GDP to GTP, converting inactive GDP-bound RAB10 into its active GTP-bound form. Thereby, stimulates SLC2A4/GLUT4 glucose transporter-enriched vesicles delivery to the plasma membrane in response to insulin. .

AccessionsENST00000494124.2
ENST00000361024.6
ENST00000602925.5 [Q5VZ89-1]
ENST00000380424.1
R4GMN2
A0A0A0MRX3
Q5VZ89
ENST00000380427.5
X6RAE7
X6R5W5
ENST00000434457.7 [Q5VZ89-7]