DENND1A report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0015031Biological processprotein transport
GO_0006897Biological processendocytosis
GO_0032456Biological processendocytic recycling
GO_0032483Biological processregulation of Rab protein signal transduction
GO_0042995Cellular componentcell projection
GO_0043231Cellular componentintracellular membrane-bounded organelle
GO_0005829Cellular componentcytosol
GO_0030136Cellular componentclathrin-coated vesicle
GO_0030665Cellular componentclathrin-coated vesicle membrane
GO_0042734Cellular componentpresynaptic membrane
GO_0005085Molecular functionguanyl-nucleotide exchange factor activity
GO_1901981Molecular functionphosphatidylinositol phosphate binding
GO_0032266Molecular functionphosphatidylinositol-3-phosphate binding

IV. Literature review

[source]
Gene nameDENND1A
Protein nameDENN domain-containing protein 1A (Connecdenn 1) (Connecdenn) (Protein FAM31A)
DENN domain containing 1A
SynonymsFAM31A
KIAA1608
DescriptionFUNCTION: Guanine nucleotide exchange factor (GEF) regulating clathrin-mediated endocytosis through RAB35 activation. Promotes the exchange of GDP to GTP, converting inactive GDP-bound RAB35 into its active GTP-bound form. Regulates clathrin-mediated endocytosis of synaptic vesicles and mediates exit from early endosomes . Binds phosphatidylinositol-phosphates (PtdInsPs), with some preference for PtdIns(3)P (By similarity). .

AccessionsENST00000373618.1 [Q8TEH3-4]
A0A8V8TNT3
Q8TEH3
ENST00000394215.7
ENST00000699491.1
ENST00000373620.7 [Q8TEH3-2]
ENST00000373624.6 [Q8TEH3-1]
A0A0A0MS48