Name | Number of supported studies | Average coverage | |
---|---|---|---|
endothelial cell | 23 studies | 42% ± 19% | |
astrocyte | 19 studies | 54% ± 21% | |
macrophage | 15 studies | 52% ± 24% | |
microglial cell | 15 studies | 52% ± 16% | |
oligodendrocyte precursor cell | 13 studies | 42% ± 17% | |
oligodendrocyte | 13 studies | 38% ± 15% | |
glutamatergic neuron | 12 studies | 56% ± 25% | |
GABAergic neuron | 11 studies | 50% ± 25% | |
fibroblast | 11 studies | 39% ± 17% | |
pericyte | 9 studies | 37% ± 14% | |
myeloid cell | 9 studies | 40% ± 21% | |
adipocyte | 8 studies | 29% ± 10% | |
smooth muscle cell | 8 studies | 30% ± 10% | |
interneuron | 6 studies | 60% ± 21% | |
dendritic cell | 6 studies | 36% ± 9% | |
endothelial cell of lymphatic vessel | 6 studies | 34% ± 12% | |
classical monocyte | 5 studies | 22% ± 5% | |
neuron | 5 studies | 55% ± 14% | |
epithelial cell | 5 studies | 36% ± 19% | |
monocyte | 5 studies | 54% ± 12% | |
granule cell | 4 studies | 43% ± 13% | |
cardiac muscle cell | 4 studies | 29% ± 3% | |
mesothelial cell | 4 studies | 27% ± 7% | |
non-classical monocyte | 4 studies | 23% ± 7% | |
Mueller cell | 4 studies | 62% ± 18% | |
amacrine cell | 4 studies | 42% ± 12% | |
retina horizontal cell | 4 studies | 51% ± 16% | |
retinal cone cell | 4 studies | 39% ± 14% | |
retinal rod cell | 4 studies | 35% ± 9% | |
GABAergic interneuron | 3 studies | 51% ± 4% | |
progenitor cell | 3 studies | 42% ± 4% | |
plasma cell | 3 studies | 30% ± 5% | |
CD4-positive, alpha-beta T cell | 3 studies | 19% ± 1% | |
vein endothelial cell | 3 studies | 39% ± 23% | |
GABAergic amacrine cell | 3 studies | 42% ± 15% | |
glycinergic amacrine cell | 3 studies | 34% ± 7% | |
retinal ganglion cell | 3 studies | 38% ± 19% | |
endothelial cell of vascular tree | 3 studies | 35% ± 17% | |
hepatocyte | 3 studies | 63% ± 17% | |
retinal pigment epithelial cell | 3 studies | 72% ± 24% | |
abnormal cell | 3 studies | 36% ± 21% | |
ependymal cell | 3 studies | 62% ± 12% | |
B cell | 3 studies | 29% ± 5% | |
alveolar macrophage | 3 studies | 54% ± 12% | |
capillary endothelial cell | 3 studies | 30% ± 7% | |
ciliated cell | 3 studies | 33% ± 8% | |
natural killer cell | 3 studies | 25% ± 2% | |
lymphocyte | 3 studies | 32% ± 14% | |
basal cell | 3 studies | 39% ± 22% | |
mast cell | 3 studies | 25% ± 10% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
esophagus | 100% | 1786.27 | 1445 / 1445 | 100% | 13.95 | 183 / 183 |
intestine | 100% | 2081.11 | 966 / 966 | 100% | 14.91 | 527 / 527 |
prostate | 100% | 1900.43 | 245 / 245 | 100% | 14.83 | 502 / 502 |
stomach | 100% | 1306.92 | 359 / 359 | 100% | 14.69 | 286 / 286 |
brain | 100% | 2505.51 | 2641 / 2642 | 100% | 16.04 | 705 / 705 |
thymus | 100% | 1973.14 | 653 / 653 | 100% | 12.15 | 604 / 605 |
ovary | 100% | 1727.41 | 180 / 180 | 100% | 12.56 | 429 / 430 |
kidney | 100% | 2031.48 | 89 / 89 | 100% | 10.90 | 897 / 901 |
breast | 100% | 1646.64 | 459 / 459 | 100% | 11.31 | 1113 / 1118 |
liver | 100% | 1229.07 | 226 / 226 | 99% | 7.64 | 403 / 406 |
uterus | 100% | 2087.02 | 170 / 170 | 99% | 9.94 | 455 / 459 |
skin | 100% | 1554.36 | 1808 / 1809 | 99% | 14.91 | 467 / 472 |
lung | 100% | 1461.25 | 577 / 578 | 99% | 10.03 | 1143 / 1155 |
bladder | 100% | 1808.33 | 21 / 21 | 98% | 9.62 | 493 / 504 |
adrenal gland | 100% | 1766.88 | 258 / 258 | 96% | 9.33 | 220 / 230 |
pancreas | 94% | 553.93 | 308 / 328 | 99% | 7.90 | 176 / 178 |
adipose | 100% | 1808.53 | 1204 / 1204 | 0% | 0 | 0 / 0 |
blood vessel | 100% | 1696.77 | 1335 / 1335 | 0% | 0 | 0 / 0 |
eye | 0% | 0 | 0 / 0 | 100% | 13.71 | 80 / 80 |
lymph node | 0% | 0 | 0 / 0 | 100% | 14.39 | 29 / 29 |
muscle | 100% | 1494.58 | 803 / 803 | 0% | 0 | 0 / 0 |
spleen | 100% | 2979.61 | 241 / 241 | 0% | 0 | 0 / 0 |
tonsil | 0% | 0 | 0 / 0 | 100% | 11.06 | 45 / 45 |
ureter | 0% | 0 | 0 / 0 | 100% | 4.15 | 1 / 1 |
peripheral blood | 100% | 2308.31 | 926 / 929 | 0% | 0 | 0 / 0 |
heart | 99% | 1158.22 | 849 / 861 | 0% | 0 | 0 / 0 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
GO_0015031 | Biological process | protein transport |
GO_0006897 | Biological process | endocytosis |
GO_0032456 | Biological process | endocytic recycling |
GO_0032483 | Biological process | regulation of Rab protein signal transduction |
GO_0042995 | Cellular component | cell projection |
GO_0043231 | Cellular component | intracellular membrane-bounded organelle |
GO_0005829 | Cellular component | cytosol |
GO_0030136 | Cellular component | clathrin-coated vesicle |
GO_0030665 | Cellular component | clathrin-coated vesicle membrane |
GO_0042734 | Cellular component | presynaptic membrane |
GO_0005085 | Molecular function | guanyl-nucleotide exchange factor activity |
GO_1901981 | Molecular function | phosphatidylinositol phosphate binding |
GO_0032266 | Molecular function | phosphatidylinositol-3-phosphate binding |
Gene name | DENND1A |
Protein name | DENN domain-containing protein 1A (Connecdenn 1) (Connecdenn) (Protein FAM31A) DENN domain containing 1A |
Synonyms | FAM31A KIAA1608 |
Description | FUNCTION: Guanine nucleotide exchange factor (GEF) regulating clathrin-mediated endocytosis through RAB35 activation. Promotes the exchange of GDP to GTP, converting inactive GDP-bound RAB35 into its active GTP-bound form. Regulates clathrin-mediated endocytosis of synaptic vesicles and mediates exit from early endosomes . Binds phosphatidylinositol-phosphates (PtdInsPs), with some preference for PtdIns(3)P (By similarity). . |
Accessions | ENST00000373618.1 [Q8TEH3-4] A0A8V8TNT3 Q8TEH3 ENST00000394215.7 ENST00000699491.1 ENST00000373620.7 [Q8TEH3-2] ENST00000373624.6 [Q8TEH3-1] A0A0A0MS48 |