GCGR | OmnibusX

Name	Number of supported studies	Average coverage
hepatocyte	4 studies	40% ± 15%	Explore

sc-RNAseq data

Insufficient scRNA-seq data for expression of GCGR at tissue level.

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
liver	100%	8872.53	226 / 226	70%	27.12	285 / 406
pancreas	93%	96.22	305 / 328	34%	1.50	60 / 178
kidney	100%	3209.42	89 / 89	16%	5.93	141 / 901
intestine	95%	76.57	915 / 966	3%	0.15	18 / 527
adrenal gland	39%	136.27	101 / 258	55%	22.56	126 / 230
skin	71%	90.42	1293 / 1809	1%	0.02	3 / 472
esophagus	37%	16.59	530 / 1445	10%	0.26	18 / 183
uterus	26%	9.18	45 / 170	16%	1.39	73 / 459
bladder	38%	12.29	8 / 21	3%	0.27	16 / 504
prostate	37%	21.16	90 / 245	0%	0.00	1 / 502
breast	33%	20.80	151 / 459	2%	0.11	24 / 1118
adipose	31%	18.99	377 / 1204	0%	0	0 / 0
thymus	22%	19.87	142 / 653	7%	1.44	45 / 605
lung	16%	4.68	91 / 578	10%	0.51	114 / 1155
stomach	23%	8.48	84 / 359	2%	0.11	5 / 286
spleen	24%	13.98	58 / 241	0%	0	0 / 0
peripheral blood	13%	14.31	123 / 929	0%	0	0 / 0
blood vessel	11%	7.05	151 / 1335	0%	0	0 / 0
muscle	11%	4.03	85 / 803	0%	0	0 / 0
ovary	4%	1.26	7 / 180	6%	0.28	25 / 430
tonsil	0%	0	0 / 0	9%	0.25	4 / 45
brain	6%	2.57	164 / 2642	1%	0.29	10 / 705
eye	0%	0	0 / 0	4%	0.12	3 / 80
heart	1%	0.34	7 / 861	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
lymph node	0%	0	0 / 0	0%	0	0 / 29
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
ureter	0%	0	0 / 0	0%	0	0 / 1

GO_0070873	Biological process	regulation of glycogen metabolic process
GO_0007584	Biological process	response to nutrient
GO_0006091	Biological process	generation of precursor metabolites and energy
GO_0007188	Biological process	adenylate cyclase-modulating G protein-coupled receptor signaling pathway
GO_0008217	Biological process	regulation of blood pressure
GO_0010628	Biological process	positive regulation of gene expression
GO_0009267	Biological process	cellular response to starvation
GO_0042594	Biological process	response to starvation
GO_0006887	Biological process	exocytosis
GO_0071377	Biological process	cellular response to glucagon stimulus
GO_0007189	Biological process	adenylate cyclase-activating G protein-coupled receptor signaling pathway
GO_0009755	Biological process	hormone-mediated signaling pathway
GO_0042593	Biological process	glucose homeostasis
GO_0007166	Biological process	cell surface receptor signaling pathway
GO_0005886	Cellular component	plasma membrane
GO_0016020	Cellular component	membrane
GO_0005768	Cellular component	endosome
GO_0004967	Molecular function	glucagon receptor activity
GO_0005085	Molecular function	guanyl-nucleotide exchange factor activity
GO_0017046	Molecular function	peptide hormone binding

Gene name	GCGR
Protein name	Glucagon receptor Glucagon receptor (GL-R)
Synonyms
Description	FUNCTION: G-protein coupled receptor for glucagon that plays a central role in the regulation of blood glucose levels and glucose homeostasis. Regulates the rate of hepatic glucose production by promoting glycogen hydrolysis and gluconeogenesis. Plays an important role in mediating the responses to fasting. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Promotes activation of adenylate cyclase. Besides, plays a role in signaling via a phosphatidylinositol-calcium second messenger system. .
Accessions	I3L454 P47871 ENST00000400723.8 ENST00000573428.1 I3L1L8 ENST00000570996.5 ENST00000671794.1

GCGR report