Name | Number of supported studies | Average coverage | |
---|---|---|---|
astrocyte | 11 studies | 32% ± 17% | |
endothelial cell | 7 studies | 27% ± 9% | |
oligodendrocyte | 7 studies | 32% ± 12% | |
oligodendrocyte precursor cell | 7 studies | 30% ± 13% | |
adipocyte | 6 studies | 21% ± 4% | |
microglial cell | 5 studies | 24% ± 5% | |
fibroblast | 5 studies | 22% ± 5% | |
glutamatergic neuron | 5 studies | 48% ± 25% | |
macrophage | 5 studies | 29% ± 9% | |
GABAergic neuron | 4 studies | 50% ± 21% | |
epithelial cell | 4 studies | 30% ± 12% | |
ciliated cell | 4 studies | 25% ± 5% | |
dendritic cell | 4 studies | 31% ± 10% | |
pericyte | 4 studies | 23% ± 6% | |
interneuron | 4 studies | 44% ± 28% | |
retinal cone cell | 3 studies | 28% ± 2% | |
connective tissue cell | 3 studies | 17% ± 2% | |
type I pneumocyte | 3 studies | 22% ± 6% | |
neuron | 3 studies | 29% ± 13% | |
plasmacytoid dendritic cell | 3 studies | 21% ± 4% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
esophagus | 100% | 1486.06 | 1445 / 1445 | 100% | 14.68 | 183 / 183 |
thymus | 100% | 2013.20 | 653 / 653 | 100% | 20.35 | 605 / 605 |
brain | 100% | 1635.80 | 2641 / 2642 | 100% | 22.23 | 705 / 705 |
breast | 100% | 1624.53 | 459 / 459 | 100% | 18.97 | 1117 / 1118 |
prostate | 100% | 1491.49 | 245 / 245 | 100% | 13.58 | 501 / 502 |
kidney | 100% | 1361.19 | 89 / 89 | 100% | 17.02 | 899 / 901 |
lung | 100% | 1629.34 | 577 / 578 | 100% | 13.99 | 1154 / 1155 |
bladder | 100% | 1544.00 | 21 / 21 | 100% | 13.38 | 502 / 504 |
uterus | 100% | 1895.53 | 170 / 170 | 100% | 16.45 | 457 / 459 |
intestine | 100% | 1297.00 | 966 / 966 | 99% | 11.58 | 524 / 527 |
ovary | 100% | 1137.64 | 180 / 180 | 99% | 9.56 | 426 / 430 |
pancreas | 100% | 956.74 | 328 / 328 | 99% | 12.71 | 176 / 178 |
stomach | 100% | 1112.94 | 359 / 359 | 99% | 11.09 | 282 / 286 |
skin | 100% | 2151.19 | 1809 / 1809 | 98% | 19.04 | 464 / 472 |
adrenal gland | 100% | 1264.82 | 258 / 258 | 98% | 11.80 | 226 / 230 |
liver | 100% | 677.90 | 225 / 226 | 95% | 8.29 | 386 / 406 |
adipose | 100% | 1758.79 | 1204 / 1204 | 0% | 0 | 0 / 0 |
lymph node | 0% | 0 | 0 / 0 | 100% | 25.09 | 29 / 29 |
spleen | 100% | 1381.12 | 241 / 241 | 0% | 0 | 0 / 0 |
tonsil | 0% | 0 | 0 / 0 | 100% | 17.00 | 45 / 45 |
ureter | 0% | 0 | 0 / 0 | 100% | 5.26 | 1 / 1 |
blood vessel | 100% | 2103.82 | 1334 / 1335 | 0% | 0 | 0 / 0 |
muscle | 100% | 976.50 | 801 / 803 | 0% | 0 | 0 / 0 |
heart | 97% | 1123.03 | 839 / 861 | 0% | 0 | 0 / 0 |
eye | 0% | 0 | 0 / 0 | 91% | 7.60 | 73 / 80 |
peripheral blood | 87% | 1275.09 | 811 / 929 | 0% | 0 | 0 / 0 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
GO_0006914 | Biological process | autophagy |
GO_0050777 | Biological process | negative regulation of immune response |
GO_0045920 | Biological process | negative regulation of exocytosis |
GO_0010506 | Biological process | regulation of autophagy |
GO_0043547 | Biological process | positive regulation of GTPase activity |
GO_0032045 | Cellular component | guanyl-nucleotide exchange factor complex |
GO_1990316 | Cellular component | Atg1/ULK1 kinase complex |
GO_0005765 | Cellular component | lysosomal membrane |
GO_0005737 | Cellular component | cytoplasm |
GO_0005085 | Molecular function | guanyl-nucleotide exchange factor activity |
GO_0005515 | Molecular function | protein binding |
Gene name | WDR41 |
Protein name | WD repeat-containing protein 41 WD repeat domain 41 isoform 1 WD repeat domain 41 (cDNA FLJ50520, highly similar to WD repeat protein 41) WD repeat domain 41 (cDNA FLJ50556, highly similar to WD repeat protein 41) WD repeat domain 41 isoform 2 WD repeat domain 41 |
Synonyms | MSTP048 |
Description | FUNCTION: Non-catalytic component of the C9orf72-SMCR8 complex, a complex that has guanine nucleotide exchange factor (GEF) activity and regulates autophagy . The C9orf72-SMCR8 complex promotes the exchange of GDP to GTP, converting inactive GDP-bound RAB8A and RAB39B into their active GTP-bound form, thereby promoting autophagosome maturation . As part of the C9orf72-SMCR8 complex, stimulates RAB8A and RAB11A GTPase activity in vitro, however WDR42 is shown not be an essential complex component for this function . The C9orf72-SMCR8 complex also acts as a negative regulator of autophagy initiation by interacting with the ULK1/ATG1 kinase complex and inhibiting its protein kinase activity . . |
Accessions | ENST00000296679.9 [Q9HAD4-1] ENST00000507029.5 [Q9HAD4-2] ENST00000515253.5 D6RBY6 H0YAA3 ENST00000513417.5 Q9HAD4 D6R9M1 D6R9E7 D6RB94 ENST00000509892.5 D6RJA5 ENST00000503035.5 D6RE66 B4DK73 ENST00000506307.5 D6RH33 D6RIX6 ENST00000509701.5 B4DHS8 ENST00000511791.1 A0A0S2Z5E0 D6RA22 ENST00000507654.5 H0Y9Z3 H0YAI6 ENST00000505129.5 ENST00000506474.5 ENST00000514559.5 ENST00000511036.5 ENST00000504895.5 ENST00000511630.6 D6RGW4 A0A0S2Z5D8 ENST00000509971.5 |