WDR41 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0006914Biological processautophagy
GO_0050777Biological processnegative regulation of immune response
GO_0045920Biological processnegative regulation of exocytosis
GO_0010506Biological processregulation of autophagy
GO_0043547Biological processpositive regulation of GTPase activity
GO_0032045Cellular componentguanyl-nucleotide exchange factor complex
GO_1990316Cellular componentAtg1/ULK1 kinase complex
GO_0005765Cellular componentlysosomal membrane
GO_0005737Cellular componentcytoplasm
GO_0005085Molecular functionguanyl-nucleotide exchange factor activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameWDR41
Protein nameWD repeat-containing protein 41
WD repeat domain 41 isoform 1
WD repeat domain 41 (cDNA FLJ50520, highly similar to WD repeat protein 41)
WD repeat domain 41 (cDNA FLJ50556, highly similar to WD repeat protein 41)
WD repeat domain 41 isoform 2
WD repeat domain 41
SynonymsMSTP048
DescriptionFUNCTION: Non-catalytic component of the C9orf72-SMCR8 complex, a complex that has guanine nucleotide exchange factor (GEF) activity and regulates autophagy . The C9orf72-SMCR8 complex promotes the exchange of GDP to GTP, converting inactive GDP-bound RAB8A and RAB39B into their active GTP-bound form, thereby promoting autophagosome maturation . As part of the C9orf72-SMCR8 complex, stimulates RAB8A and RAB11A GTPase activity in vitro, however WDR42 is shown not be an essential complex component for this function . The C9orf72-SMCR8 complex also acts as a negative regulator of autophagy initiation by interacting with the ULK1/ATG1 kinase complex and inhibiting its protein kinase activity . .

AccessionsENST00000296679.9 [Q9HAD4-1]
ENST00000507029.5 [Q9HAD4-2]
ENST00000515253.5
D6RBY6
H0YAA3
ENST00000513417.5
Q9HAD4
D6R9M1
D6R9E7
D6RB94
ENST00000509892.5
D6RJA5
ENST00000503035.5
D6RE66
B4DK73
ENST00000506307.5
D6RH33
D6RIX6
ENST00000509701.5
B4DHS8
ENST00000511791.1
A0A0S2Z5E0
D6RA22
ENST00000507654.5
H0Y9Z3
H0YAI6
ENST00000505129.5
ENST00000506474.5
ENST00000514559.5
ENST00000511036.5
ENST00000504895.5
ENST00000511630.6
D6RGW4
A0A0S2Z5D8
ENST00000509971.5