SPATA13 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0046847Biological processfilopodium assembly
GO_0051056Biological processregulation of small GTPase mediated signal transduction
GO_0030334Biological processregulation of cell migration
GO_0016477Biological processcell migration
GO_0030032Biological processlamellipodium assembly
GO_0032587Cellular componentruffle membrane
GO_0030175Cellular componentfilopodium
GO_0005654Cellular componentnucleoplasm
GO_0005829Cellular componentcytosol
GO_0030027Cellular componentlamellipodium
GO_0005737Cellular componentcytoplasm
GO_0005085Molecular functionguanyl-nucleotide exchange factor activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameSPATA13
Protein nameSPATA13
Spermatogenesis-associated protein 13 (APC-stimulated guanine nucleotide exchange factor 2) (Asef2)
Spermatogenesis associated 13
Synonyms
DescriptionFUNCTION: Acts as a guanine nucleotide exchange factor (GEF) for RHOA, RAC1 and CDC42 GTPases. Regulates cell migration and adhesion assembly and disassembly through a RAC1, PI3K, RHOA and AKT1-dependent mechanism. Increases both RAC1 and CDC42 activity, but decreases the amount of active RHOA. Required for MMP9 up-regulation via the JNK signaling pathway in colorectal tumor cells. Involved in tumor angiogenesis and may play a role in intestinal adenoma formation and tumor progression. .

AccessionsENST00000424834.6 [Q96N96-6]
ENST00000382108.8 [Q96N96-6]
A0A024RDM6
ENST00000382095.8 [Q96N96-1]
ENST00000409126.5
E9PFR9
ENST00000494772.5
Q5VX67
ENST00000488060.1
ENST00000434675.5
ENST00000454083.1
ENST00000399949.6 [Q96N96-2]
V9GZ16
J3KQJ8
ENST00000343003.10 [Q96N96-3]
Q96N96