Name | Number of supported studies | Average coverage | |
---|---|---|---|
macrophage | 40 studies | 42% ± 14% | |
conventional dendritic cell | 27 studies | 45% ± 19% | |
classical monocyte | 24 studies | 37% ± 13% | |
endothelial cell | 24 studies | 29% ± 16% | |
astrocyte | 22 studies | 48% ± 17% | |
dendritic cell | 21 studies | 56% ± 17% | |
mast cell | 21 studies | 31% ± 10% | |
plasmacytoid dendritic cell | 21 studies | 57% ± 16% | |
non-classical monocyte | 19 studies | 32% ± 11% | |
monocyte | 17 studies | 38% ± 18% | |
oligodendrocyte | 17 studies | 72% ± 19% | |
oligodendrocyte precursor cell | 17 studies | 61% ± 18% | |
microglial cell | 16 studies | 47% ± 14% | |
myeloid cell | 16 studies | 45% ± 19% | |
pericyte | 14 studies | 24% ± 14% | |
fibroblast | 14 studies | 24% ± 5% | |
endothelial cell of lymphatic vessel | 12 studies | 29% ± 11% | |
glutamatergic neuron | 12 studies | 71% ± 17% | |
GABAergic neuron | 11 studies | 69% ± 21% | |
smooth muscle cell | 11 studies | 21% ± 4% | |
neuron | 10 studies | 53% ± 19% | |
B cell | 9 studies | 24% ± 6% | |
alveolar macrophage | 8 studies | 64% ± 16% | |
amacrine cell | 8 studies | 60% ± 18% | |
plasma cell | 7 studies | 32% ± 8% | |
mononuclear phagocyte | 7 studies | 38% ± 14% | |
interneuron | 7 studies | 76% ± 14% | |
retinal ganglion cell | 7 studies | 58% ± 19% | |
connective tissue cell | 6 studies | 30% ± 10% | |
retina horizontal cell | 6 studies | 50% ± 23% | |
Mueller cell | 6 studies | 40% ± 11% | |
hematopoietic precursor cell | 5 studies | 40% ± 15% | |
leukocyte | 5 studies | 29% ± 11% | |
myofibroblast cell | 5 studies | 28% ± 6% | |
retinal bipolar neuron | 5 studies | 58% ± 21% | |
pro-B cell | 5 studies | 32% ± 8% | |
adipocyte | 5 studies | 22% ± 2% | |
abnormal cell | 4 studies | 36% ± 12% | |
glial cell | 4 studies | 40% ± 15% | |
granule cell | 4 studies | 39% ± 16% | |
progenitor cell | 4 studies | 33% ± 12% | |
hematopoietic stem cell | 4 studies | 33% ± 13% | |
capillary endothelial cell | 4 studies | 17% ± 1% | |
OFF-bipolar cell | 4 studies | 44% ± 10% | |
ON-bipolar cell | 4 studies | 64% ± 21% | |
retinal rod cell | 4 studies | 28% ± 11% | |
plasmablast | 3 studies | 46% ± 14% | |
differentiation-committed oligodendrocyte precursor | 3 studies | 64% ± 9% | |
neural crest cell | 3 studies | 25% ± 6% | |
GABAergic interneuron | 3 studies | 75% ± 2% | |
common myeloid progenitor | 3 studies | 27% ± 10% | |
lymphocyte | 3 studies | 18% ± 2% | |
precursor B cell | 3 studies | 28% ± 17% | |
endothelial cell of artery | 3 studies | 22% ± 5% | |
tissue-resident macrophage | 3 studies | 43% ± 16% | |
GABAergic amacrine cell | 3 studies | 77% ± 12% | |
glycinergic amacrine cell | 3 studies | 67% ± 17% | |
rod bipolar cell | 3 studies | 66% ± 8% | |
germinal center B cell | 3 studies | 33% ± 7% | |
intermediate monocyte | 3 studies | 40% ± 15% | |
endothelial cell of vascular tree | 3 studies | 23% ± 8% | |
inflammatory macrophage | 3 studies | 22% ± 4% | |
neural progenitor cell | 3 studies | 60% ± 6% | |
ependymal cell | 3 studies | 44% ± 22% | |
granulocyte monocyte progenitor cell | 3 studies | 30% ± 11% | |
chondrocyte | 3 studies | 36% ± 14% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
brain | 100% | 7666.53 | 2642 / 2642 | 100% | 19.02 | 705 / 705 |
lung | 100% | 3923.01 | 577 / 578 | 96% | 4.07 | 1104 / 1155 |
adrenal gland | 100% | 2404.91 | 257 / 258 | 95% | 3.53 | 219 / 230 |
thymus | 98% | 1718.07 | 642 / 653 | 89% | 2.36 | 537 / 605 |
breast | 99% | 2358.90 | 453 / 459 | 88% | 3.21 | 988 / 1118 |
uterus | 99% | 2844.91 | 168 / 170 | 88% | 4.26 | 403 / 459 |
pancreas | 92% | 1405.44 | 301 / 328 | 92% | 3.16 | 163 / 178 |
esophagus | 82% | 1852.77 | 1187 / 1445 | 97% | 5.89 | 178 / 183 |
ovary | 99% | 2442.73 | 179 / 180 | 77% | 1.92 | 329 / 430 |
skin | 77% | 2364.36 | 1394 / 1809 | 94% | 6.27 | 443 / 472 |
bladder | 100% | 2198.76 | 21 / 21 | 62% | 2.12 | 310 / 504 |
prostate | 96% | 1621.53 | 235 / 245 | 53% | 0.88 | 266 / 502 |
kidney | 62% | 802.15 | 55 / 89 | 87% | 3.58 | 784 / 901 |
stomach | 81% | 1252.74 | 290 / 359 | 64% | 2.31 | 184 / 286 |
intestine | 92% | 2114.95 | 884 / 966 | 43% | 1.30 | 227 / 527 |
liver | 44% | 481.78 | 99 / 226 | 67% | 1.70 | 273 / 406 |
spleen | 100% | 3114.18 | 241 / 241 | 0% | 0 | 0 / 0 |
adipose | 100% | 2921.80 | 1199 / 1204 | 0% | 0 | 0 / 0 |
blood vessel | 100% | 3067.81 | 1329 / 1335 | 0% | 0 | 0 / 0 |
tonsil | 0% | 0 | 0 / 0 | 98% | 3.94 | 44 / 45 |
lymph node | 0% | 0 | 0 / 0 | 97% | 7.50 | 28 / 29 |
heart | 87% | 1462.52 | 752 / 861 | 0% | 0 | 0 / 0 |
muscle | 86% | 1133.19 | 688 / 803 | 0% | 0 | 0 / 0 |
peripheral blood | 57% | 2202.39 | 534 / 929 | 0% | 0 | 0 / 0 |
eye | 0% | 0 | 0 / 0 | 45% | 1.10 | 36 / 80 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
GO_0032956 | Biological process | regulation of actin cytoskeleton organization |
GO_0072660 | Biological process | maintenance of protein location in plasma membrane |
GO_0031122 | Biological process | cytoplasmic microtubule organization |
GO_0051496 | Biological process | positive regulation of stress fiber assembly |
GO_0030032 | Biological process | lamellipodium assembly |
GO_0031929 | Biological process | TOR signaling |
GO_0061024 | Biological process | membrane organization |
GO_0032147 | Biological process | activation of protein kinase activity |
GO_0045742 | Biological process | positive regulation of epidermal growth factor receptor signaling pathway |
GO_0045724 | Biological process | positive regulation of cilium assembly |
GO_0007264 | Biological process | small GTPase-mediated signal transduction |
GO_0010975 | Biological process | regulation of neuron projection development |
GO_0051897 | Biological process | positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction |
GO_0007399 | Biological process | nervous system development |
GO_1903566 | Biological process | positive regulation of protein localization to cilium |
GO_0016477 | Biological process | cell migration |
GO_0042127 | Biological process | regulation of cell population proliferation |
GO_0030705 | Biological process | cytoskeleton-dependent intracellular transport |
GO_0005886 | Cellular component | plasma membrane |
GO_0031410 | Cellular component | cytoplasmic vesicle |
GO_0016020 | Cellular component | membrane |
GO_0005813 | Cellular component | centrosome |
GO_0030142 | Cellular component | COPI-coated Golgi to ER transport vesicle |
GO_0005794 | Cellular component | Golgi apparatus |
GO_0005814 | Cellular component | centriole |
GO_0005783 | Cellular component | endoplasmic reticulum |
GO_0005829 | Cellular component | cytosol |
GO_0005737 | Cellular component | cytoplasm |
GO_0036064 | Cellular component | ciliary basal body |
GO_0030027 | Cellular component | lamellipodium |
GO_0005080 | Molecular function | protein kinase C binding |
GO_0042803 | Molecular function | protein homodimerization activity |
GO_0005085 | Molecular function | guanyl-nucleotide exchange factor activity |
GO_0005158 | Molecular function | insulin receptor binding |
GO_0031682 | Molecular function | G-protein gamma-subunit binding |
GO_0005092 | Molecular function | GDP-dissociation inhibitor activity |
GO_0005154 | Molecular function | epidermal growth factor receptor binding |
GO_0001965 | Molecular function | G-protein alpha-subunit binding |
GO_0035091 | Molecular function | phosphatidylinositol binding |
GO_0043184 | Molecular function | vascular endothelial growth factor receptor 2 binding |
GO_0043539 | Molecular function | protein serine/threonine kinase activator activity |
GO_0042169 | Molecular function | SH2 domain binding |
GO_0008017 | Molecular function | microtubule binding |
GO_0051959 | Molecular function | dynein light intermediate chain binding |
GO_0043422 | Molecular function | protein kinase B binding |
GO_0003779 | Molecular function | actin binding |
Gene name | CCDC88A |
Protein name | Coiled-coil domain containing 88A Girdin (Akt phosphorylation enhancer) (APE) (Coiled-coil domain-containing protein 88A) (G alpha-interacting vesicle-associated protein) (GIV) (Girders of actin filament) (Hook-related protein 1) (HkRP1) CCDC88A protein |
Synonyms | APE GRDN KIAA1212 |
Description | FUNCTION: Bifunctional modulator of guanine nucleotide-binding proteins (G proteins) . Acts as a non-receptor guanine nucleotide exchange factor which binds to and activates guanine nucleotide-binding protein G(i) alpha subunits . Also acts as a guanine nucleotide dissociation inhibitor for guanine nucleotide-binding protein G(s) subunit alpha GNAS . Essential for cell migration . Interacts in complex with G(i) alpha subunits with the EGFR receptor, retaining EGFR at the cell membrane following ligand stimulation and promoting EGFR signaling which triggers cell migration . Binding to Gi-alpha subunits displaces the beta and gamma subunits from the heterotrimeric G-protein complex which enhances phosphoinositide 3-kinase (PI3K)-dependent phosphorylation and kinase activity of AKT1/PKB . Phosphorylation of AKT1/PKB induces the phosphorylation of downstream effectors GSK3 and FOXO1/FKHR, and regulates DNA replication and cell proliferation (By similarity). Binds in its tyrosine-phosphorylated form to the phosphatidylinositol 3-kinase (PI3K) regulatory subunit PIK3R1 which enables recruitment of PIK3R1 to the EGFR receptor, enhancing PI3K activity and cell migration . Plays a role as a key modulator of the AKT-mTOR signaling pathway, controlling the tempo of the process of newborn neuron integration during adult neurogenesis, including correct neuron positioning, dendritic development and synapse formation (By similarity). Inhibition of G(s) subunit alpha GNAS leads to reduced cellular levels of cAMP and suppression of cell proliferation . Essential for the integrity of the actin cytoskeleton . Required for formation of actin stress fibers and lamellipodia . May be involved in membrane sorting in the early endosome . Plays a role in ciliogenesis and cilium morphology and positioning and this may partly be through regulation of the localization of scaffolding protein CROCC/Rootletin . . |
Accessions | ENST00000645477.1 ENST00000426576.6 ENST00000336838.10 [Q3V6T2-3] ENST00000647547.1 A0A2R8Y7L3 ENST00000412148.6 ENST00000645860.1 A0A2R8Y5D7 Q3V6T2 ENST00000644193.1 A0A2R8Y5R4 H7C2C6 ENST00000645168.1 ENST00000647341.1 H0Y7K3 A0A2R8YG73 ENST00000643375.1 ENST00000643440.1 A0A2R8Y7D9 ENST00000644033.1 A0A2R8YFK8 ENST00000647291.1 ENST00000263630.13 [Q3V6T2-2] A0A2R8Y562 A0A2R8YGU1 ENST00000436346.7 [Q3V6T2-1] A0A2R8Y820 ENST00000643265.1 ENST00000644630.1 ENST00000647517.1 ENST00000644512.1 A0A2R8Y7B1 A0A2R8YFV1 ENST00000647401.1 A0A2R8Y885 ENST00000647098.1 A0A2R8Y802 A0A2R8YG52 H0Y470 ENST00000645072.1 ENST00000645311.1 ENST00000471947.2 A0A2R8Y4X4 ENST00000456975.1 ENST00000644825.1 ENST00000644415.1 ENST00000476903.1 Q6DCA5 A0A2R8Y4Z5 Q6PAV0 ENST00000646796.1 [Q3V6T2-5] Q86YH1 A0A2R8Y6B2 A0A2R8Y7D4 ENST00000647396.1 ENST00000643413.1 [Q3V6T2-4] ENST00000642200.1 [Q3V6T2-1] A0A2R8Y4C6 A0A2R8YD81 A0A2R8YCW0 ENST00000642890.1 A0A2R8YCJ0 ENST00000642563.1 A0A2R8Y4W8 A0A2R8Y846 H0Y7U8 A0A2R8YCU9 A0A2U3TZV9 ENST00000645529.1 A0A2R8YD99 ENST00000413716.7 ENST00000444458.5 ENST00000645031.1 A0A2R8YDS8 ENST00000646285.1 |