CCDC88A report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0032956Biological processregulation of actin cytoskeleton organization
GO_0072660Biological processmaintenance of protein location in plasma membrane
GO_0031122Biological processcytoplasmic microtubule organization
GO_0051496Biological processpositive regulation of stress fiber assembly
GO_0030032Biological processlamellipodium assembly
GO_0031929Biological processTOR signaling
GO_0061024Biological processmembrane organization
GO_0032147Biological processactivation of protein kinase activity
GO_0045742Biological processpositive regulation of epidermal growth factor receptor signaling pathway
GO_0045724Biological processpositive regulation of cilium assembly
GO_0007264Biological processsmall GTPase-mediated signal transduction
GO_0010975Biological processregulation of neuron projection development
GO_0051897Biological processpositive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
GO_0007399Biological processnervous system development
GO_1903566Biological processpositive regulation of protein localization to cilium
GO_0016477Biological processcell migration
GO_0042127Biological processregulation of cell population proliferation
GO_0030705Biological processcytoskeleton-dependent intracellular transport
GO_0005886Cellular componentplasma membrane
GO_0031410Cellular componentcytoplasmic vesicle
GO_0016020Cellular componentmembrane
GO_0005813Cellular componentcentrosome
GO_0030142Cellular componentCOPI-coated Golgi to ER transport vesicle
GO_0005794Cellular componentGolgi apparatus
GO_0005814Cellular componentcentriole
GO_0005783Cellular componentendoplasmic reticulum
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0036064Cellular componentciliary basal body
GO_0030027Cellular componentlamellipodium
GO_0005080Molecular functionprotein kinase C binding
GO_0042803Molecular functionprotein homodimerization activity
GO_0005085Molecular functionguanyl-nucleotide exchange factor activity
GO_0005158Molecular functioninsulin receptor binding
GO_0031682Molecular functionG-protein gamma-subunit binding
GO_0005092Molecular functionGDP-dissociation inhibitor activity
GO_0005154Molecular functionepidermal growth factor receptor binding
GO_0001965Molecular functionG-protein alpha-subunit binding
GO_0035091Molecular functionphosphatidylinositol binding
GO_0043184Molecular functionvascular endothelial growth factor receptor 2 binding
GO_0043539Molecular functionprotein serine/threonine kinase activator activity
GO_0042169Molecular functionSH2 domain binding
GO_0008017Molecular functionmicrotubule binding
GO_0051959Molecular functiondynein light intermediate chain binding
GO_0043422Molecular functionprotein kinase B binding
GO_0003779Molecular functionactin binding

IV. Literature review

[source]
Gene nameCCDC88A
Protein nameCoiled-coil domain containing 88A
Girdin (Akt phosphorylation enhancer) (APE) (Coiled-coil domain-containing protein 88A) (G alpha-interacting vesicle-associated protein) (GIV) (Girders of actin filament) (Hook-related protein 1) (HkRP1)
CCDC88A protein
SynonymsAPE
GRDN
KIAA1212
DescriptionFUNCTION: Bifunctional modulator of guanine nucleotide-binding proteins (G proteins) . Acts as a non-receptor guanine nucleotide exchange factor which binds to and activates guanine nucleotide-binding protein G(i) alpha subunits . Also acts as a guanine nucleotide dissociation inhibitor for guanine nucleotide-binding protein G(s) subunit alpha GNAS . Essential for cell migration . Interacts in complex with G(i) alpha subunits with the EGFR receptor, retaining EGFR at the cell membrane following ligand stimulation and promoting EGFR signaling which triggers cell migration . Binding to Gi-alpha subunits displaces the beta and gamma subunits from the heterotrimeric G-protein complex which enhances phosphoinositide 3-kinase (PI3K)-dependent phosphorylation and kinase activity of AKT1/PKB . Phosphorylation of AKT1/PKB induces the phosphorylation of downstream effectors GSK3 and FOXO1/FKHR, and regulates DNA replication and cell proliferation (By similarity). Binds in its tyrosine-phosphorylated form to the phosphatidylinositol 3-kinase (PI3K) regulatory subunit PIK3R1 which enables recruitment of PIK3R1 to the EGFR receptor, enhancing PI3K activity and cell migration . Plays a role as a key modulator of the AKT-mTOR signaling pathway, controlling the tempo of the process of newborn neuron integration during adult neurogenesis, including correct neuron positioning, dendritic development and synapse formation (By similarity). Inhibition of G(s) subunit alpha GNAS leads to reduced cellular levels of cAMP and suppression of cell proliferation . Essential for the integrity of the actin cytoskeleton . Required for formation of actin stress fibers and lamellipodia . May be involved in membrane sorting in the early endosome . Plays a role in ciliogenesis and cilium morphology and positioning and this may partly be through regulation of the localization of scaffolding protein CROCC/Rootletin . .

AccessionsENST00000645477.1
ENST00000426576.6
ENST00000336838.10 [Q3V6T2-3]
ENST00000647547.1
A0A2R8Y7L3
ENST00000412148.6
ENST00000645860.1
A0A2R8Y5D7
Q3V6T2
ENST00000644193.1
A0A2R8Y5R4
H7C2C6
ENST00000645168.1
ENST00000647341.1
H0Y7K3
A0A2R8YG73
ENST00000643375.1
ENST00000643440.1
A0A2R8Y7D9
ENST00000644033.1
A0A2R8YFK8
ENST00000647291.1
ENST00000263630.13 [Q3V6T2-2]
A0A2R8Y562
A0A2R8YGU1
ENST00000436346.7 [Q3V6T2-1]
A0A2R8Y820
ENST00000643265.1
ENST00000644630.1
ENST00000647517.1
ENST00000644512.1
A0A2R8Y7B1
A0A2R8YFV1
ENST00000647401.1
A0A2R8Y885
ENST00000647098.1
A0A2R8Y802
A0A2R8YG52
H0Y470
ENST00000645072.1
ENST00000645311.1
ENST00000471947.2
A0A2R8Y4X4
ENST00000456975.1
ENST00000644825.1
ENST00000644415.1
ENST00000476903.1
Q6DCA5
A0A2R8Y4Z5
Q6PAV0
ENST00000646796.1 [Q3V6T2-5]
Q86YH1
A0A2R8Y6B2
A0A2R8Y7D4
ENST00000647396.1
ENST00000643413.1 [Q3V6T2-4]
ENST00000642200.1 [Q3V6T2-1]
A0A2R8Y4C6
A0A2R8YD81
A0A2R8YCW0
ENST00000642890.1
A0A2R8YCJ0
ENST00000642563.1
A0A2R8Y4W8
A0A2R8Y846
H0Y7U8
A0A2R8YCU9
A0A2U3TZV9
ENST00000645529.1
A0A2R8YD99
ENST00000413716.7
ENST00000444458.5
ENST00000645031.1
A0A2R8YDS8
ENST00000646285.1